]> 1.3 Michel Dumontier Sept 4, 2008 http://dumontierlab.com Natalia Villanueva-Rosales Contains knowledge of the pharmacogenomics of depression. Pharmacogenomics of Depression en antidepressant dopamine reuptake inhibitor monoamine oxidase inhibitor norepinephrine-dopamine reuptake inhibitor norepinephrine reuptake inhibitor noradrenergic and specific serotonergic antidepressant reversible inhibitor of monoamine oxidase type-A serotonin-noradrenaline-dopamine reuptake inhibitor serotonin-norepinephrine reuptake inhibitor selective serotonin reuptake enhancer selective serotonin reuptake inhibitor tricyclic antidepressant tetracyclic antidepressant ABCB1_3435_C ABCB1_3435_T Alaproclate Amineptine AmitriptylineABCB1Interaction1 AmitryptylineCRHInteraction1 BDNFDepessionInteraction1 BDNF_Val66Met Black Brasofensine Brofaromine BupropionCYP2B6Interaction1 BupropionCYP2D6Interaction1 BupropionSLC18A2Interaction1 Butriptyline COMTDepressionMeasure1 2.19 COMTL CRHR1DesipramineInteraction1 CRHR1DesipramineInteraction2 CRHR1DesipramineInteraction3 CRHR1DesipramineInteraction4 CRHR1DesipramineInteraction5 CRHR1DesipramineInteraction6 CRHR1FluoxetineInteraction1 CRHR1FluoxetineInteraction2 CRHR1FluoxetineInteraction3 CRHR1FluoxetineInteraction4 CRHR1FluoxetineInteraction5 CRHR1FluoxetineInteraction6 CRHR1FluoxetineOutcome1 67.3 CRHR1FluoxetineOutcome2 63.1 CRHR1FluoxetineOutcome3 51.2 CRHR1FluoxetineOutcome4 37.1 CRHR1FluoxetineOutcome5 61.0 CRHR1FluoxetineOutcome6 60.5 CRHR1_rs1876828_A CRHR1_rs1876828_G CRHR1_rs242939_A CRHR1_rs242939_G CRHR1_rs242941_G CRHR1_rs242941_T CYP2C19FluvoxamineInteractionS1 CYP2C19ParoxetineInteractionS1 CYP2D6*1 CYP2D6*1X2 CYP2D6*1X3 CYP2D6*4 CYP2D6*5 CYP2D6*6 CitalopramHTR2ADrugTreatment1 CitalopramHTR2ADrugTreatment2 CitalopramHTR2ADrugTreatment3 CitalopramHTR2ADrugTreatment4 CitalopramHTR2ADrugTreatmentOutcome1 79.9 CitalopramHTR2ADrugTreatmentOutcome2 62.4 CitalopramHTR2ADrugTreatmentOutcome3 79.7 CitalopramHTR2ADrugTreatmentOutcome4 63.5 CitalopramHTR2AInteraction1 CitalopramHTR2AInteraction2 Dapoxetine DesipramineCRHInteraction1 DesipramineCRHR1Treatment1 DesipramineCRHR1Treatment10 DesipramineCRHR1Treatment11 DesipramineCRHR1Treatment12 DesipramineCRHR1Treatment2 DesipramineCRHR1Treatment3 DesipramineCRHR1Treatment4 DesipramineCRHR1Treatment5 DesipramineCRHR1Treatment6 DesipramineCRHR1Treatment7 DesipramineCRHR1Treatment8 DesipramineCRHR1Treatment9 DesipramineCYP2D6InducedSideEffect1 DesipramineCYP2D6Interaction1 DesipramineCYP2D6Treatment1 DesipramineICERInteraction1 DesipraminePDE1CInteraction1 DesipraminePDE1CInteraction2 DesipraminePDE1CTreatment1 DesipraminePDE1CTreatment2 DesipraminePDE1CTreatmentOutcome1 5.16 DesipraminePDE1CTreatmentOutcome2 4.6 Desvenlafaxine Dibenzepin Dothiepin Etoperidone FluoxetineCRHInteraction1 FluoxetineCRHR1Treatment1 FluoxetineCRHR1Treatment10 FluoxetineCRHR1Treatment11 FluoxetineCRHR1Treatment12 FluoxetineCRHR1Treatment2 FluoxetineCRHR1Treatment3 FluoxetineCRHR1Treatment4 FluoxetineCRHR1Treatment5 FluoxetineCRHR1Treatment6 FluoxetineCRHR1Treatment7 FluoxetineCRHR1Treatment8 FluoxetineCRHR1Treatment9 FluoxetinePDE11AInteraction1 FluoxetinePDE11ATreatment1 FluoxetinePDE11ATreatmentOutcome1 5.12 FluoxetinePDE1AInteraction1 FluoxetinePDE1ATreatment1 FluoxetinePDE1ATreatmentOutcome1 8.8 FluoxetinePDE6AInteraction1 FluoxetinePDE6ATreatment1 FluoxetinePDE6ATreatmentOutcome1 4.4 FluoxetineTreatment1 FluoxetineTreatmentOutcome1 62.4 FluoxetineTreatmentOutcome2 60.8 HTR2A_rs7997012_A HTR2A_rs7997012_G Harmaline ICER ImipramineCRHInteraction1 Iprindole Lofepramine MDR1AAmitriptylineInteraction1 Melitracen MianserinCRHInteraction1 Milnacipram MilnacipramCRHInteraction1 Mirtazapine MirtazapineCRHInteraction1 Nialamide Nomifensine NortriptylineABCB1Interaction1 NortriptylineABCB1Interaction2 NortriptylineABCB1Interaction3 NortriptylineABCB1Treatment1 NortriptylineABCB1TreatmentDoseRecommenation NortriptylineABCB1Treatment2 NortriptylineABCB1Treatment3 NortriptylineABCB1TreatmentOutcome1 0.0 NortriptylineABCB1TreatmentOutcome2 11.0 NortriptylineABCB1TreatmentOutcome3 25.0 NortriptylineInducedSideEffect1 NortriptylineInducedSideEffect2 NortriptylineInducedSideEffect3 NortriptylineTreatment1 NortriptylineTreatmentOutcome1 59.4 NortriptylineTreatmentOutcome2 54.6 103 PDE11ADepressionInteraction1 PDE11ADepressionInteractionH1 PDE11ADepressionInteractionH2 PDE11ADepressionInteractionH3 PDE11ADepressionInteractionH4 PDE11ADepressionInteractionH5 PDE11ADepressionInteractionMeasure 2.1 PDE11A_rs1370656_A PDE11A_rs1370656_C PDE11A_rs1465831_G PDE11A_rs1465831_T PDE11A_rs1561320_C PDE11A_rs1561320_T PDE11A_rs1866212_A PDE11A_rs1866212_G PDE11A_rs1880916_C PDE11A_rs1880916_T PDE11A_rs3770018_A PDE11A_rs3770018_C PDE11A_rs3770034_A PDE11A_rs3770034_G PDE1A_rs1549870_A PDE1A_rs1549870_G PDE1C_rs30585_A PDE1C_rs30585_C PDE1C_rs992185_A PDE1C_rs992185_C PDE6A_rs2544934_A PDE6A_rs2544934_T PDE11ADepressionInteraction1 PDE9ADepressionInteractionMeasure 0.6 PDE11A_rs3770018_A PDE11A_rs3770018_C Postural Hypotension Rasagiline ReboxetineCRHInteraction1 Tesofensine Tianeptine TianeptineCRHInteraction1 Toloxatone Trimipramine Vanoxerine VenlafaxineCRHInteraction1 VenlafaxineCYP2D6Interaction1 VenlafaxineCYP2D6Interaction2 VenlafaxineCYP2D6Interaction3 VenlafaxineCYP2D6Interaction4 VenlafaxineCYP2D6Interaction5 VenlafaxineCYP2D6Interaction6 VenlafaxineCYP2D6Interaction1 VenlafaxineCYP2D6Interaction2 VenlafaxineCYP2D6Interaction3 VenlafaxineCYP2D6Interaction4 VenlafaxineCYP2D6Interaction5 VenlafaxineCYP2D6Interaction6 VenlafaxineCYP2D6Outcome1 2.3 VenlafaxineCYP2D6Outcome2 2.3 VenlafaxineCYP2D6Outcome3 2.3 VenlafaxineCYP2D6Outcome4 0.49 VenlafaxineCYP2D6Outcome5 0.3 VenlafaxineCYP2D6Outcome6 0.49 VenlafaxineCYP2D6Treatment1 VenlafaxineCYP2D6Treatment2 VenlafaxineCYP2D6Treatment3 VenlafaxineCYP2D6Treatment4 VenlafaxineCYP2D6Treatment5 VenlafaxineCYP2D6Treatment6 Viloxazine White Zimelidine _3435_C _3435_T percent rs1370656_A rs1370656_C rs1465831_G rs1465831_T rs1549870_A rs1549870_G rs1561320_C rs1561320_T rs1866212_A rs1866212_G rs1876828_A rs1876828_G rs1880916_C rs1880916_T rs242939_A rs242939_G rs242941_G rs242941_T rs2544934_A rs2544934_T rs30585_A rs30585_C rs3770018_A rs3770018_C rs3770034_A rs3770034_G rs3770018_A rs3770018_C rs7997012_A rs7997012_G rs992185_A rs992185_C Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression Regulation of the human corticotropin-releasing-hormone gene promoter activity by antidepressant drugs in Neuro-2A and AtT-20 cells Inducible cAMP early repressor regulates corticosterone suppression after tricyclic antidepressant treatment Clinical implications of genetic polymorphism of CYP2D6 in Mexican Americans Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response Bupropion: pharmacology and therapeutic applications Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression Duloxetine Escitalopram Mianserin Atomoxetine Reboxetine Opipramol phosphodiesterase 1C phosphodiesterase 9A Amitriptyline Amoxapine Bupropion Citalopram Clomipramine Desipramine Doxepin Fluoxetine Fluvoxamine Imipramine Isocarboxazid Maprotiline Mirtazapine Nefazodone Nortriptyline Pargyline Paroxetine Phenmetrazine Phenelzine Protriptyline Selegiline Sertraline Tranylcypromine Trazodone Venlafaxine Moclobemide