]> http://dumontierlab.com en Natalia Villanueva-Rosales Feb 1, 2008 PharmGKB knowledge base 1.0 Instantiated pharmacogenomics ontology with PharmGKB web services. Michel Dumontier duloxetine Drug Trade Names:Cymbalta, escitalopram Drug Trade Names:Lexapro, telithromycin Drug Trade Names:Ketek, atazanavir Drug Trade Names:REYATAZ, cyclin-dependent kinase inhibitor 1A (pmid1, Cipgkb) Gene Symbol: CDKN1A Gene Alternate Names: CApmid0,CDK-interaction protein 1,CIpgkb,DNA synthesis inhibitor,pmid1,SDI1,WAF1,melanoma differentiation associated protein 6,wild-type p53-activated fragment 1, Gene Alternate Symbols: CApmid0,CDKN1,CIpgkb,MDA-6,pmid1,SDI1,WAF1,pmid1CIpgkb, benzodiazepines calcium channel blocking agents cyclin-dependent kinase inhibitor 1B (pmid7, Kipgkb) Gene Symbol: CDKN1B gene Alternate Symbols: CDKN4,KIpgkb,pmid7KIpgkb, cyclin-dependent kinase inhibitor 2A (melanoma, pgkb6, inhibits CDK4) Gene Symbol: CDKN2A Gene Alternate Names: ARF,CDK4 inhibitor pgkb6-INK4,CDK4I,CMM2,INK4,INK4a,MTS1,cell cycle negative regulator beta,cyclin-dependent kinase inhibitor 2A, pgkb4ARF,cyclin-dependent kinase inhibitor pgkb2, pgkb6INK4a alternatively spliced form,cyclin-dependent kinase inhibitor pgkb6,multiple tumor suppressor 1,pgkb4,pgkb6,pgkb9, Gene Alternate Symbols: ARF,CDK4I,CDKN2,CMM2,INK4,INK4A,INK4a,MLM,MTS1,pgkb6,Tpgkb6,pgkb4,pgkb4ARF,pgkb6,pgkb6INK4,pgkb6INK4a,pgkb9, propoxyphene and acetaminophen Drug Trade Names:Darvocet-N 100,Darvocet-N 50,E-Lor,Propacet 100,Wygesic, carboxylesterase 1 (monocyte/macrophage serine esterase 1) Gene Symbol: CES1 Gene Alternate Names: CEH,CES2,HMSE,HMSE1,SES1,carboxylesterase 2 (liver),cholesteryl ester hydrolase,egasyn,liver carboxylesterase, Gene Alternate Symbols: ACAT,CEH,CES1A1,CES1A1a,CES1A1b,CES1A1c,CES1A2,CES2,HMSE,HMSE1,MGC117365,SES1,TGH, ezetimibe Drug Trade Names:Zetia, beta-adrenergic blocking agents cholinergic receptor, nicotinic, alpha 3 Gene Symbol: CHRNA3 Gene Alternate Names: Cholinergic receptor, neuronal nicotinic, alpha polypeptide-3,cholinergic receptor, nicotinic, alpha polypeptide 3, Gene Alternate Symbols: MGC104879, cholinergic receptor, nicotinic, alpha 7 Gene Symbol: CHRNA7 Gene Alternate Names: a7 nicotinic acetylcholine receptor,alpha 7 neuronal nicotinic acetylcholine receptor,alpha-7 nicotinic cholinergic receptor subunit,alpha7 nicotinic receptor subunit,cholinergic receptor, nicotinic, alpha polypeptide 7,neuronal acetylcholine receptor protein, alpha-7 chain precursor,neuronal nicotinic acetylcholine receptor alpha-7 subunit,nicotinic acetylcholine receptor alpha7 subunit precursor,nicotinic cholinergic receptor alpha 7, Gene Alternate Symbols: NACHRA7, ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Gene Symbol: ABCC2 Gene Alternate Names: ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 2; ABCC2,ATP-binding cassette sub-family C (CFTR\/MRP) member 2,DJS,Human canalicular multispecific organic anion transporter (cMOAT) mRNA, complete cds.,MRpmid,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; MRpmid,MULTISPECIFIC ORGANIC ANION TRANSPORTER, CANALICULAR; CMOAT,cMRP,canalicular multispecific organic anion transporter, Gene Alternate Symbols: ABC30,CMOAT,DJS,KIAA1010,MRpmid,U63970.1,cMRP, catechol-O-methyltransferase Gene Symbol: COMT corticotropin releasing hormone Gene Symbol: CRH Gene Alternate Symbols: CRF, C-reactive protein, pentraxin-related Gene Symbol: CRP Gene Alternate Names: C-reactive protein, Gene Alternate Symbols: MGC88244,PTX1, cytochrome P450, family 2, subfamily A, polypeptide 6 Gene Symbol: CYpmidA6 Gene Alternate Names: coumarin 7-hydroxylase,cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 3,cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6,flavoprotein-linked monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: CPA6,CYpmidA,CYpmidA3,P450C2A,P450PB, cytochrome P450, family 2, subfamily B, polypeptide 6 Gene Symbol: CYpmidB6 Gene Alternate Names: CPB6,CYpmidB,CYPIIB6,cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6, Gene Alternate Symbols: CPB6,CYpmidB,CYPIIB6,IIB1,P450, cytochrome P450, family 2, subfamily C, polypeptide 19 Gene Symbol: CYpmidC19 Gene Alternate Names: CPCJ,CYP 2C,P450IIC19,S-mephenytoin 4-hydroxylase,cytochrome P-450 II C,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19,cytochrome p450,flavoprotein-linked monooxygenase,mephenytoin 4'-hydroxylase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: CPCJ,CYP 2C,CYpmidC,P450C2C,P450IIC19, cytochrome P450, family 2, subfamily C, polypeptide 8 Gene Symbol: CYpmidC8 Gene Alternate Names: CPC8,P450 MP-12/MP-20,P450 form 1,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8,flavoprotein-linked monooxygenase,mephenytoin 4-hydroxylase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: CPC8,P450 MP-12/MP-20, cytochrome P450, family 2, subfamily C, polypeptide 9 Gene Symbol: CYpmidC9 Gene Alternate Names: P450 MP-4,P450 PB-1,P450IIC9,cytochrome P-450 S-mephenytoin 4-hydroxylase,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9,flavoprotein-linked monooxygenase,mephenytoin 4-hydroxylase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: *1,CPC9,CYpmidC,CYpmidC10,CYpmidC9*1,CYpmidC9*1A,MGC88320,P450 MP-4,P450 PB-1,P450IIC9, cytochrome P450, family 2, subfamily D, polypeptide 6 Gene Symbol: CYpmidD6 Gene Alternate Names: CPD6,CYpmidD,P450-DB1,P450C2D,cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6,cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1,debrisoquine 4-hydroxylase,flavoprotein-linked monooxygenase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: CPD6,CYpmidD,CYpmidD@,CYpmidDL1,MGC120389,MGC120390,P450-DB1,P450C2D, nicotine dependency insulin-like growth factor 2 mRNA binding protein 2 Gene Symbol: IGF2Bpmid Gene Alternate Names: IGF-II mRNA-binding protein 2, Gene Alternate Symbols: IMP-2,IMpmid,VICKZ2,p62, phospholipase C, eta 1 Gene Symbol: PLCH1 Gene Alternate Names: KIAA1069,KIAA1069 protein,phospholipase C-like 3, Gene Alternate Symbols: DKFZp434C1372,KIAA1069,MGC117152,PLCL3,PLCeta1, KIAA0143 protein (non-HGNC gene) Gene Symbol: KIAA0143 Gene Alternate Symbols: DKFZp781J0562, mannosidase, alpha, class 2B, member 2 Gene Symbol: MAN2B2 Gene Alternate Names: KIAA0935,epididymis-specific alpha-mannosidase precursor, Gene Alternate Symbols: KIAA0935, leucine rich repeat containing 37A Gene Symbol: LRRC37A Gene Alternate Names: KIAA0563 gene product, Gene Alternate Symbols: DKFZp686N1231,KIAA0563, KIAA0157 Gene Symbol: KIAA0157 Gene Alternate Names: KIAA0157 protein, Gene Alternate Symbols: Em:AC068896.4,FLJ22338, structural maintenance of chromosomes flexible hinge domain containing 1 Gene Symbol: SMCHD1 Gene Alternate Names: KIAA0650 protein, Gene Alternate Symbols: DKFZp686O0631,KIAA0650, neuroblastoma breakpoint family, member 1 Gene Symbol: NBPF1 Gene Alternate Names: hypothetical protein FLJ20719, Gene Alternate Symbols: AB13,AB14,AB23,AD2,FLJ20719,KIAA1693,NBG,NBPF, KIAA1155 protein (non-HGNC gene) Gene Symbol: KIAA1155 KIAA1467 Gene Symbol: KIAA1467 Gene Alternate Names: KIAA1467 protein, Gene Alternate Symbols: DKFZp781O012, 5-fluorouracil pesticides cancer or viral infections sulfotransferase SULT6B1 (non-HGNC gene) Gene Symbol: SULT6B1 Gene Alternate Names: sulfotransferase SULT6B1, Beta adrenergic antagonists cytochrome P450, family 2, subfamily E, polypeptide 1 Gene Symbol: CYpmidE1 Gene Alternate Names: cytochrome P450, subfamily IIE (ethanol-inducible),cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1,flavoprotein-linked monooxygenase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: CPE1,CYpmidE,P450-J,P450C2E, cytochrome P450, family 3, subfamily A, polypeptide 4 Gene Symbol: CYP3A4 Gene Alternate Names: P450-III, steroid inducible,cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3,cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4,glucocorticoid-inducible P450,nifedipine oxidase, Gene Alternate Symbols: *1A,CP33,CP34,CYP3A,CYP3A3,CYP3A4*1,CYP3A4*1A,HLP,MGC126680,NF-25,P450C3,P450PCN1, perhexiline Heart Failure orbofiban anthracycline High incidence of secondary brain tumours after radiotherapy and antimetabolites Journal Lancet Year 1999 Pages 34-9 Abstract: BACKGROUND: Brain tumours rarely occur in survivors of childhood acute lymphoblastic leukaemia after cranial radiotherapy. An unusually high frequency of brain tumours seen among children enrolled in one of our leukaemia treatment protocols, Total Therapy Study XII, prompted us to identify the potential causes of this complication. METHODS: We assessed clinical, biological, and pharmacokinetic features in all 52 children who received prophylactic cranial radiotherapy. We compared the cumulative incidence of brain tumours between subgroups, and with that of 421 children who received radiotherapy in previous studies. FINDINGS: The incidence of brain tumours among irradiated children (six of 52, 12.8% [SE 5.0]) was high compared with patients in the same study who did not receive radiotherapy (none of 101; p=0.0008) and with other protocols that included cranial radiotherapy (p<0.0001). Of the six children, four had erythrocyte concentrations of thioguanine nucleotide metabolites higher than the 70th percentile for the entire cohort, and three had a genetic defect in thiopurine catabolism. The 8-year cumulative incidence of brain tumour among children with defective versus wild-type thiopurine methyltransferase phenotype was 42.9% (SE 20.6) versus 8.3% (4.7; p=0.0077). This protocol differed from previous protocols, in that more intensive systemic antimetabolite therapy was given before and during radiotherapy. INTERPRETATION: These data support the elimination of prophylactic radiotherapy for acute lymphoblastic leukaemia except in patients at high risk of central-nervous-system relapse. Underlying genetic characteristics and treatment variables may be associated with an increased risk of radiation-associated brain tumours. Authors: Relling M V,Rubnitz J E,Rivera G K,Boyett J M,Hancock M L,Felix C A,Kun L E,Walter A W,Evans W E,Pui C H, Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis Journal Lancet Year 1997 Pages 1217-9 Abstract: BACKGROUND: Coronary stents are an effective treatment for selected coronary stenoses. However, thrombosis of the stented segment is a major adverse complication. Platelet aggregation has a key role in stent thrombosis. We investigated whether a polymorphism of platelet glycoprotein IIIa gene (PIA2) is associated with an increased risk of coronary stent thrombosis. METHODS: 318 consecutive patients were followed up for 30 days after coronary stent insertion. The primary endpoints were death, myocardial infarction, stent-vessel occlusion, and coronary artery bypass surgery. Gel electrophoresis of PCR products was used to identify the PIA1 and PIA2 alleles. The relative risk of stent occlusion was calculated from the odds ratio on logistic regression analysis. FINDINGS: 63 (19.8%) of patients had the PIA2 allele and 255 (80.2%) were homozygous for PIA1. Baseline clinical, angiographic, and procedural features did not differ between the groups with and without the PIA2 allele. Occlusion of the stent vessel occurred in five (1.9%) patients homozygous for PIA1 and six (9.5%) patients with PIA2 allele (odds ratio 5.26 [95% CI 1.55-17.85]). On multivariate regression analysis PIA1/A2 genotype was the only significant independent predictor of stent thrombosis. INTERPRETATION: Patients with the pIA2 allele have an increased risk of coronary stent thrombosis, which may warrant antiplatelet therapy with glycoprotein-IIb/IIIa inhibitors, although bleeding complications may also increase. Authors: Walter D H,Sch�chinger V,Elsner M,Dimmeler S,Zeiher A M, Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia Journal Br J Haematol Year 1995 Pages 761-6 Abstract: Heparin-induced thrombocytopenia (HIT) is mediated by a heparin-dependent antibody/platelet factor 4/heparin complex binding to platelets via the Fc gamma receptor (type IIA). A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine. In the presence of murine monoclonal IgG1 the former phenotype (Fc gamma RIIAArg131) is functionally characterized by strong platelet aggregation (high responder) and the latter (Fc gamma RIIAHis131) by poor aggregation (low responder). In the presence of human IgG2 the opposite response is observed. It has recently been shown that the heparin-dependent antibody is predominantly of this subclass. We hypothesize that a relationship exists between Fc gamma RIIAHis131 and the development of HIT. We studied 24 normal individuals and 20 HIT patients using VM58, a murine monoclonal IgG1, to characterize the phenotype by platelet aggregrometry, and PCR products, amplified with primers bordering the Fc gamma RIIA polymorphism and hybridized with oligonucleotide probes specific for the single base mutation, to determine the genotype. The distribution of phenotypes and genotypes in the two populations differed, with a greater prevalence of the Fc gamma RIIAHis131 allele in the HIT patient population. Homozygous Fc gamma RIIAArg131 individuals were absent from this group. We conclude that the presence of the Fc gamma RIIAHis131 allele is associated with a predisposition to HIT. Authors: Burgess J K,Lindeman R,Chesterman C N,Chong B H, Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism Journal Cardiovasc Drugs Ther Year 2000 Pages 427-32 Abstract: Insertion (I)/deletion (D) polymorphism of the ACE gene has been reported to be involved in various cardiovascular diseases. We investigated prospectively whether the response to the ACE inhibitor fosinopril varied according to the ACE genotype in previously untreated Greek hypertensive patients. After a 4-week observation period, fosinopril was administered at a dose of 20 mg daily and blood pressure was measured weekly for 6 months. The study population consisted of 104 hypertensive patients (46 male, 58 female). There were no differences in age, gender, body mass index, and pretreatment blood pressure levels among patients with the DD, ID, and II genotypes (n= 42, 30, 32, respectively). The reduction in systolic blood pressure was significantly greater in patients carrying the DD compared to II or ID genotypes (5.6 +/- 3.1 vs. 3.1 +/- 1.1 or 3.6 +/- 2.2, respectively; ANOVA, p < 0.05). The reduction in diastolic blood pressure was also significantly greater in DD hypertensives compared with II or ID (8.9 +/- 6 vs. 5.5 +/- 3.4 or 5.8 +/- 4, respectively; ANOVA, p < 0.05). The age and BMI were not correlated with the changes in SBP or DBP that were observed after fosinopril administration. In conclusion, the ACE gene genotype was shown to influence the response to fosinopril in hypertensive patients. Authors: Stavroulakis G A,Makris T K,Krespi P G,Hatzizacharias A N,Gialeraki A E,Anastasiadis G,Triposkiadis P,Kyriakidis M, Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension Journal Lancet Year 1997 Pages 1353-7 Abstract: BACKGROUND: Abnormalities in renal sodium transport may be involved in hypertension. Adducin, an alpha/beta heterodimeric protein found in the renal tubule is thought to regulate ion transport through changes in the actin cytoskeleton. We investigated whether an alpha-adducin polymorphism (Gly 460 Trp) is involved in essential hypertension in two separate populations. METHODS: Linkage analysis of three DNA markers at different distances from the alpha-adducin locus (20-2500 kb) was done in 137 hypertensive sibling-pairs. 477 hypertensive and 322 normotensive individuals were genotyped for the alpha-adducin polymorphism. The blood-pressure response to acute and chronic changes in sodium balance was studied in hypertensive individuals with and without the 460 Trp alpha-adducin allele. FINDINGS: Significant linkage was found for all three markers in the sibling-pair study. The extra shared alleles (9.1%, 6.5%, and 4.7%) and the significance level for linkage (p = 0.0006, p = 0.0119, and p = 0.0211) both decreased with increasing distance from the alpha-adducin locus. There was a significant association between the 460 Trp mutation and hypertension (p = 0.0003). In the salt-sensitivity test, to assess the acute blood-pressure response to changes in body sodium in 86 hypertensive patients, the decrease in mean arterial pressure was greater in 65 patients who were heterozygous for the mutant allele (Gly/Trp) than in 21 wild-type homozygotes (Gly/Gly) (mean decrease 15.9 [SE 2.0] vs 7.4 [1.3] mm Hg; p = 0.001). Similarly, 21 heterozygous hypertensive patients showed a greater fall in mean arterial pressure in response to 2 months' treatment with hydrochlorothiazide than did 37 wild-type homozygous hypertensive patients (mean decrease 14.7 [2.2] vs 6.8 [1.4] mm Hg; p = 0.002). INTERPRETATION: Our findings of significant linkage of the alpha-adducin locus to essential hypertension and greater sensitivity to changes in sodium balance among patients with the mutant allele suggest that alpha-adducin is associated with a salt-sensitive form of essential hypertension. We suggest the alpha-adducin polymorphism may identify hypertensive patients who will benefit from diuretic treatment or manoeuvres to reduce total body sodium. Authors: Cusi D,Barlassina C,Azzani T,Casari G,Citterio L,Devoto M,Glorioso N,Lanzani C,Manunta P,Righetti M,Rivera R,Stella P,Troffa C,Zagato L,Bianchi G, Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency Journal J Child Adolesc Psychopharmacol Year 2000 Pages 27-34 Abstract: The clinical course of a 9-year-old diagnosed with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and Tourette's disorder and treated with a combination of methylphenidate, clonidine, and fluoxetine is described. The patient experienced over a 10-month period, signs and symptoms suggestive of metabolic toxicity marked by bouts of gastrointestinal distress, low-grade fever, incoordination, and disorientation. Generalized seizures were observed, and the patient lapsed into status epilepticus followed by cardiac arrest and subsequently expired. At autopsy, blood, brain, and other tissue concentrations of fluoxetine and norfluoxetine were several-fold higher than expected based on literature reports for overdose situations. The medical examiner's report indicated death caused by fluoxetine toxicity. As the child's adoptive parents controlled medication access, they were investigated by social welfare agencies. Further genetic testing of autopsy tissue revealed the presence of a gene defect at the cytochrome P450 CYpmidD locus, which results in poor metabolism of fluoxetine. As a result of this and other evidence, the investigation of the adoptive parents was terminated. This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYpmidD6 gene that results in impaired drug metabolism. Issues relevant to child and adolescent psychopharmacology arising from this case are discussed. Authors: Sallee F R,DeVane C L,Ferrell R E, Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase Journal Drug Metab Dispos Year 2001 Pages 601-5 Abstract: Thiopurine drugs are used to treat patients with neoplasia and autoimmune disease as well as transplant recipients. These agents are metabolized, in part, by S-methylation catalyzed by thiopurine methyltransferase (TPMT). The discovery nearly two decades ago that levels of TPMT activity in human tissues are controlled by a common genetic polymorphism led to one of the best examples of the potential importance of pharmacogenetics for clinical medicine. Specifically, it is now known that patients with inherited very low levels of TPMT activity are at greatly increased risk for thiopurine-induced toxicity such as myelosuppression when treated with standard doses of these drugs, while subjects with very high activity may be undertreated. Furthermore, recent reports indicate that TPMT may be the target for clinically significant drug interactions and that this common genetic polymorphism might be a risk factor for the occurrence of therapy-dependent secondary leukemia. In parallel with these clinical reports, the molecular basis for the TPMT polymorphism has been determined as a result of cloning and characterization of the human TPMT cDNA and gene. Those advances led to the description and characterization of a series of single nucleotide polymorphisms that result in low levels of enzyme activity as well as a polymorphic variable number tandem repeat within the 5'-flanking region of the TPMT gene that may "modulate" level of enzyme activity. As a result of these observations, the TPMT genetic polymorphism represents a model system for the way in which basic pharmacogenetic information is developed and applied to clinical medicine. Authors: Weinshilboum R, Pharmacogenetics and folate metabolism -- a promising direction Journal Pharmacogenomics Year 2002 Pages 299-313 Abstract: Folate metabolism is the target of two major drug groups: folate antagonists (e.g., methotrexate) and thymidylate synthase inhibitors (for example, 5-fluorouracil). These agents are widely used in cancer chemotherapy, as treatment for rheumatoid arthritis, and for other conditions. The administration of these drugs in cancer chemotherapy can induce a state of acute folate depletion with sometimes life-threatening toxic sequelae. Recent studies suggest that polymorphisms in folate-metabolizing enzymes may modify the therapeutic effectiveness and toxicity of drugs targeting folate metabolism. This review briefly summarizes major drugs targeting the folate pathway and describes common polymorphisms in folate-metabolizing enzymes and transport proteins. Pharmacogenetic studies investigating the relevance of these polymorphisms with respect to patients' response to antifolate chemotherapeutic agents are discussed. Investigating genetic variability in folate metabolism in the framework of pharmacogenetics is a promising field. Findings to date illustrate the potential for targeting therapy based on patients' genotypes with improved outcomes and reduced toxicity. Authors: Ulrich Cornelia M,Robien Kim,Sparks Rachel, Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease Journal Aliment Pharmacol Ther Year 2002 Pages 1743-50 Abstract: BACKGROUND: Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects. AIM: To evaluate the importance of TPMT activity in the management of azathioprine therapy in inflammatory bowel disease. METHODS: Clinical response, adverse effects and haematological parameters were determined and correlated with TPMT enzyme activity and genotype in 106 patients with inflammatory bowel disease. RESULTS: Ninety-six patients had high TPMT activity, and 10 had intermediate activity. Nineteen patients (18%) were intolerant to azathioprine. Fifteen (16%) of those with high TPMT activity were intolerant, compared with five (50%) with intermediate activity [odds ratio (OR), 5.4; 95% confidence interval (CI), 1.5-19.8]. Complete remission was achieved in 63% of cases, and complete or partial remission in 79%. Interestingly, very high TPMT activity (> 14 units/mL red blood cells) was significantly associated with non-response, irrespective of the time on azathioprine (OR, 0.21; 95% CI, 0.07-0.68). TPMT gene mutations correlated with TPMT activity. CONCLUSIONS: Inflammatory bowel disease patients with intermediate TPMT activity have an increased risk of azathioprine toxicity. Conversely, very high TPMT activity predicts treatment failure. TPMT genotype predicted TPMT phenotype in this study. Authors: Ansari A,Hassan C,Duley J,Marinaki A,Shobowale-Bakre E-M,Seed P,Meenan J,Yim A,Sanderson J, Resistance to antifolates Journal Oncogene Year 2003 Pages 7431-57 Abstract: The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served as a basis for the subsequent exploration and understanding of the mechanisms of resistance to a variety of diverse antineoplastics with different cellular targets. This section describes the bases for intrinsic and acquired antifolate resistance within the context of the current understanding of the mechanisms of actions and cytotoxic determinants of these agents. This encompasses impaired drug transport into cells, augmented drug export, impaired activation of antifolates through polyglutamylation, augmented hydrolysis of antifolate polyglutamates, increased expression and mutation of target enzymes, and the augmentation of cellular tetrahydrofolate-cofactor pools in cells. This chapter also describes how these insights are being utilized to develop gene therapy approaches to protect normal bone marrow progenitor cells as a strategy to improve the efficacy of bone marrow transplantation. Finally, clinical studies are reviewed that correlate the cellular pharmacology of methotrexate with the clinical outcome in children with neoplastic dl:Diseases treated with this antifolate. Authors: Zhao Rongbao,Goldman I David, Intrinsic and acquired resistance to methotrexate in acute leukemia Journal N Engl J Med Year 1996 Pages 1041-8 Abstract: null Authors: Gorlick R,Goker E,Trippett T,Waltham M,Banerjee D,Bertino J R, The history of folic acid Journal Br J Haematol Year 2001 Pages 579-89 Abstract: null Authors: Hoffbrand A V,Weir D G, Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Journal Proc Natl Acad Sci U S A Year 2000 Pages 3473-8 Abstract: To evaluate whether alterations in the multidrug-resistance (MDR)-1 gene correlate with intestinal MDR-1 expression and uptake of orally administered P-glycoprotein (PGP) substrates, we analyzed the MDR-1 sequence in 21 volunteers whose PGP expression and function in the duodenum had been determined by Western blots and quantitative immunohistology (n = 21) or by plasma concentrations after orally administered digoxin (n = 8 + 14). We observed a significant correlation of a polymorphism in exon 26 (C3435T) of MDR-1 with expression levels and function of MDR-1. Individuals homozygous for this polymorphism had significantly lower duodenal MDR-1 expression and the highest digoxin plasma levels. Homozygosity for this variant was observed in 24% of our sample population (n = 188). This polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of MDR-1. Authors: Hoffmeyer S,Burk O,von Richter O,Arnold H P,dlckm�ller J,Johne A,Cascorbi I,Gerloff T,Roots I,Eichelbaum M,Brinkmann U, CYpmidE1*1D regulatory polymorphism: association with alcohol and nicotine dependence Journal Pharmacogenetics Year 2003 Pages 321-8 Abstract: OBJECTIVE: CYpmidE1 bioactivates environmental protoxins and metabolizes alcohol. CYpmidE1 is induced by alcohol and cigarette smoking and may contribute to metabolic tolerance in alcoholics. The CYpmidE1*1D polymorphism has been associated with greater CYpmidE1 inducibility. One objective was to determine the frequency of the variant allele in eight ethnic groups. Further, the Canadian Native Indian, South-east Asian Canadian and Caucasian Canadian groups were stratified by alcohol and nicotine dependence (as measured by DSM-IV criteria) to examine the potential association of CYpmidE1*1D with drug dependence. RESULTS AND CONCLUSIONS: We found a significantly greater frequency of the CYpmidE1*1D allele among Indo-Asian Canadians (0.31), Chinese Canadians (0.19), Taiwanese (0.20), Japanese Canadians (0.18), African Americans (0.13), African Canadians (0.10) and Canadian Native Indians (0.09) compared to Caucasian Canadians (0.02). Although the power of the association study was low among some subgroups, the CYpmidE1*1D genotype (subjects with at least one variant allele) was associated with alcohol as well as nicotine dependence. Specifically, Canadian Native Indians dependent on nicotine alone or alcohol alone exhibited significantly greater CYpmidE1*1D frequencies compared to non-drug dependent controls, while the variant frequency among Southeast Asians dependent on nicotine was greater than their non-drug dependent counterparts. We also found that CYpmidE1*1D genotype was associated with significantly greater 3-hydroxycotinine per cigarette in African Americans. The variable frequency of CYpmidE1*1D among ethnic groups suggests a greater risk for dl:Diseases putatively related to CYpmidE1 in some non-Caucasian ethnic groups. The association of CYpmidE1*1D with alcohol and nicotine dependence suggests that CYpmidE1 may contribute to the development of these dependencies. Authors: Howard Lisa A,Ahluwalia Jasjit S,Lin Shih-Ku,Sellers Edward M,Tyndale Rachel F, The effect of smoking and cytochrome P450 CYpgkbA2 genetic polymorphism on clozapine clearance and dose requirement Journal Pharmacogenetics Year 2003 Pages 169-72 Abstract: Clozapine is an atypical antipsychotic drug that is metabolized to a major extent by the cytochrome P450 enzyme CYpgkbA2. Smoking is a potent inducer of CYpgkbA2 enzyme activity, resulting in significant lower clozapine serum concentrations in smokers compared with non-smokers, upon a given dose. Recently, a single nucleotide polymorphism identified at position 734 of the CYpgkbA2 gene, was reported to affect the inducibility of the enzyme. Because this polymorphism in relation to smoking behaviour may be relevant in treatment with clozapine, we studied the effect of CYpgkbA2 genotype on clozapine clearance and dose requirement in a group of 80 smoking and non-smoking schizophrenic patients on long-term clozapine therapy. Clozapine serum concentration and CYpgkbA2 genotype had been determined routinely by high-performance liquid chromatography and polymerase chain reaction analyses, respectively. In smokers, the clozapine serum concentration corrected for dose (C/D ratio) was on average 2.5 times lower compared with non-smokers, indicating an enhanced clearance. The mean required maintenance doses of clozapine for smokers and non-smokers were 382 mg/day and 197 mg/day, respectively (P < 0.01). Neither among smokers, nor among non-smokers mean C/D ratios and daily doses did vary significantly between patients with the different CYpgkbA2 genotypes. The results show that clozapine clearance and daily dose requirement are strongly associated with smoking behaviour, while the CYpgkbA2 genetic polymorphism seems to have no significant clinical effect. Dosage adjustment based on smoking behaviour would be of value in order to lower the incidence of non-therapeutic serum drug levels and, consequently, intoxication or inadequate antipsychotic response. Authors: van der Weide Jan,Steijns Linda S,van Weelden Marga J, Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness Journal Proc Natl Acad Sci U S A Year 2000 Pages 10483-8 Abstract: The human beta(2)-adrenergic receptor gene has multiple single-nucleotide polymorphisms (SNPs), but the relevance of chromosomally phased SNPs (haplotypes) is not known. The phylogeny and the in vitro and in vivo consequences of variations in the 5' upstream and ORF were delineated in a multiethnic reference population and an asthmatic cohort. Thirteen SNPs were found organized into 12 haplotypes out of the theoretically possible 8,192 combinations. Deep divergence in the distribution of some haplotypes was noted in Caucasian, African-American, Asian, and Hispanic-Latino ethnic groups with >20-fold differences among the frequencies of the four major haplotypes. The relevance of the five most common beta(2)-adrenergic receptor haplotype pairs was determined in vivo by assessing the dlnchodilator response to beta agonist in asthmatics. Mean responses by haplotype pair varied by >2-fold, and response was significantly related to the haplotype pair (P = 0.007) but not to individual SNPs. Expression vectors representing two of the haplotypes differing at eight of the SNP loci and associated with divergent in vivo responsiveness to agonist were used to transfect HEK293 cells. beta(2)-adrenergic receptor mRNA levels and receptor density in cells transfected with the haplotype associated with the greater physiologic response were approximately 50% greater than those transfected with the lower response haplotype. The results indicate that the unique interactions of multiple SNPs within a haplotype ultimately can affect biologic and therapeutic phenotype and that individual SNPs may have poor predictive power as pharmacogenetic loci. Authors: Drysdale C M,McGraw D W,Stack C B,Stephens J C,Judson R S,Nandabalan K,Arnold K,Ruano G,Liggett S B, cytochrome P450, family 3, subfamily A, polypeptide 5 Gene Symbol: CYP3A5 Gene Alternate Names: CP35,P450PCN3,PCN3,aryl hydrocarbon hydroxylase,cytochrome P-450,cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5,flavoprotein-linked monooxygenase,microsomal monooxygenase,niphedipine oxidase,xenobiotic monooxygenase, Gene Alternate Symbols: CP35,P450PCN3,PCN3, Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine Journal J Clin Oncol Year 2001 Pages 2293-301 Abstract: PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their clinical management. PATIENTS AND METHODS: TPMT phenotype and thiopurine metabolism were assessed in all patients referred between 1994 and 1999 for evaluation of excessive toxicity while receiving MP or AZA. TPMT activity was measured by radiochemical analysis, TPMT genotype was determined by mutation-specific polymerase chain reaction restriction fragment length polymorphism analyses for the TPMT*2, *3A, *3B, and *3C alleles, and thiopurine metabolites were measured by high-performance liquid chromatography. RESULTS: Of 23 patients evaluated, six had TPMT deficiency (activity < 5 U/mL of packed RBCs [pRBCs]; homozygous mutant), nine had intermediate TPMT activity (5 to 13 U/mL of pRBCs; heterozygotes), and eight had high TPMT activity (> 13.5 U/mL of pRBCs; homozygous wildtype). The 65.2% frequency of TPMT-deficient and heterozygous individuals among these toxic patients is significantly greater than the expected 10% frequency in the general population (P <.001, chi(2)). TPMT phenotype and genotype were concordant in all TPMT-deficient and all homozygous-wildtype patients, whereas five patients with heterozygous phenotypes did not have a TPMT mutation detected. Before thiopurine dosage adjustments, TPMT-deficient patients experienced more frequent hospitalization, more platelet transfusions, and more missed doses of chemotherapy. Hematologic toxicity occurred in more than 90% of patients, whereas hepatotoxicity occurred in six patients (26%). Both patients who presented with only hepatic toxicity had a homozygous-wildtype TPMT phenotype. After adjustment of thiopurine dosages, the TPMT-deficient and heterozygous patients tolerated therapy without acute toxicity. CONCLUSION: There is a significant (> six-fold) overrepresentation of TPMT deficiency or heterozygosity among patients developing dose-limiting hematopoietic toxicity from therapy containing thiopurines. However, with appropriate dosage adjustments, TPMT-deficient and heterozygous patients can be treated with thiopurines, without acute dose-limiting toxicity. Authors: Evans W E,Hon Y Y,Bomgaars L,Coutre S,Holdsworth M,Janco R,Kalwinsky D,Keller F,Khatib Z,Margolin J,Murray J,Quinn J,Ravindranath Y,Ritchey K,Roberts W,Rogers Z R,Schiff D,Steuber C,Tucci F,Kornegay N,Krynetski E Y,Relling M V, Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan Journal J Clin Oncol Year 2004 Pages 1382-8 Abstract: PURPOSE: Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38. This study prospectively evaluated the association between the prevalence of severe toxicity and UGT1A1 genetic variation. PATIENTS AND METHODS: Sixty-six cancer patients with advanced disease refractory to other treatments received irinotecan 350 mg/m(2) every 3 weeks. Toxicity and pharmacokinetic data were measured during cycle 1. UGT1A1 variants (-3279G>T, -3156G>A, promoter TA indel, 211G>A, 686C>A) were genotyped. RESULTS: The prevalence of grade 4 neutropenia was 9.5%. Grade 4 neutropenia was much more common in patients with the TA indel 7/7 genotype (3 of 6 patients; 50%) compared with 6/7 (3 of 24 patients; 12.5%) and 6/6 (0 of 29 patients; 0%) (P =.001). The TA indel genotype was significantly associated with the absolute neutrophil count nadir (7/7 < 6/7 < 6/6, P =.02). The relative risk of grade 4 neutropenia was 9.3 (95% CI, 2.4 to 36.4) for the 7/7 patients versus the rest of the patients. Pretreatment total bilirubin levels (mean +/- standard deviation) were significantly higher in patients with grade 4 neutropenia (0.83 +/- 0.08 mg/dL) compared to those without grade 4 neutropenia (0.47 +/- 0.03 mg/dL; P <.001). The -3156G>A variant seemed to distinguish different phenotypes of total bilirubin within the TA indel genotypes. The -3156 genotype and the SN-38 area under the concentration versus time curve were significant predictors of ln(absolute neutrophil count nadir; r(2) = 0.51). CONCLUSION: UGT1A1 genotype and total bilirubin levels are strongly associated with severe neutropenia, and could be used to identify cancer patients predisposed to the severe toxicity of irinotecan. The hypothesis that the -3156G>A variant is a better predictor of UGT1A1 status than the previously reported TA indel requires further testing. Authors: Innocenti Federico,Undevia Samir D,Iyer Lalitha,Chen Pei Xian,Das Soma,Kocherginsky Masha,Karrison Theodore,Janisch Linda,Ram�rez Jacqueline,Rudin Charles M,Vokes Everett E,Ratain Mark J, oxaliplatin Drug Trade Names:Eloxatin, aspirin-induced asthma gefitinib Drug Trade Names:Iressa, phenytoin, carbamazepine Non-small cell lung cancer echinacea raltitrexed Drug Trade Names:Tomudex, 3,4-methylenedioxymethamphetamine telcyta tranilast calcein The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients Journal Pharmacogenetics Year 2004 Pages 665-71 Abstract: OBJECTIVE: Cyclosporine is extensively metabolized by cytochrome-P450 3A (CYP3A) enzymes in the liver and intestine including the CYP3A5 isoenzyme. CYP3A5 is also expressed in the kidney and has been implicated in blood pressure regulation. Appreciable expression of CYP3A5 occurs in carriers of the CYP3A5*1 allele, while the CYP3A5*3 allele is associated with low expression. We tested whether the presence of the CYP3A5*1 allele in renal transplant recipients and in donor kidneys influences cyclosporine dose requirements, blood pressure and long-term graft survival in renal transplant patients during chronic treatment with a cyclosporine-based immunosuppressive regimen. METHODS: We studied 399 Caucasian patients from our single-center registry with stable graft function for more than 10 weeks after transplantation. The genotypes for CYP3A5*1/*3 were determined by a TaqMan PCR method. Cyclosporine dose requirements, blood pressure and graft survival were analyzed in relation to the presence or absence of the CYP3A5*1 allele in recipients and donor kidneys. RESULTS: The CYP3A5*1 allele was found in 15.5% of the recipients and in 11.8% of the donor kidneys. The recipient CYP3A5*1 allele had no effect on cyclosporine dose and blood concentrations at trough with and without dose-adjustment. Blood pressure, number of antihypertensive compounds used for treatment and graft survival evaluated by Kaplan-Meier curves and Cox regression analysis were also not affected by the CYP3A5*1 allele either in recipients or donor kidneys. CONCLUSIONS: Cyclosporine dose requirements, blood pressure and long-term renal graft survival are not influenced by the CYP3A5*1 allele in Caucasian patients. Authors: Kreutz Reinhold,Z�rcher Heiko,Kain Silke,Martus Peter,Offermann Gerd,Beige Joachim, glutathione S-transferase omega 2 Gene Symbol: GSTO2 Gene Alternate Names: bA127L20.1 (novel glutathione-S-transferase), Gene Alternate Symbols: bA127L20.1, glutathione S-transferase omega 1 Gene Symbol: GSTO1 Gene Alternate Names: GSTTLpmid8,pmid8,glutathione S-transferase omega 1-1,glutathione transferase omega,glutathione transferase omega 1,glutathione-S-transferase like, Gene Alternate Symbols: DKFZp686H13163,GSTTLpmid8,pmid8, Organ Transplantation statin rosuvastatin Drug Trade Names:Crestor, Life-threatening serotonin syndrome in a patient with chronic heart failure and CYpmidD6*1/*5 Journal Mayo Clin Proc Year 2004 Pages 1444-8 Abstract: We report a case of serotonin syndrome that occurred in a patient with chronic heart failure associated with a panic disorder. The 39-year-old Japanese man had been treated with paroxetine at 20 mg/d for 1 1/2 years. He presented with rhabdomyolysis, renal failure, fulminant liver failure, cardiac conduction disturbance, and disseminated intravascular coagulation, as well as conventional symptoms of serotonin syndrome including alterations in cognition (disorientation, confusion) and behavior (restlessness), autonomic nervous system dysfunction (fever, shivering), and abnormal neuromuscular activity (ataxia, hyperreflexia, myoclonus). All medications prescribed before hospital admission were discontinued. After 24 hours of continuous venovenous hemofiltration, diuresis resumed and renal and liver function improved rapidly. Disorientation, restlessness, hyperreflexia, and myoclonus abated slowly over the next 72 hours. The patient's anxiety subsided more slowly, and he recovered completely 1 week later. The plasma concentration of paroxetine was elevated far above the upper limit of the therapeutic range. The patient had cytochrome P-450 (CYP) 2D6*1/*5, a heterozygosity of an inactivated allele of CYpmidD6, which metabolizes paroxetine. The patient was determined to be an intermediate metabolizer who was potentially vulnerable to paroxetine, a major inhibitor of CYpmidD6. Heart failure is often accompanied by psychiatric disorders. A wide range of drugs commonly prescribed for these conditions, including beta-blockers, antiarrhythmics, and antidepressants, are metabolized by CYpmidD6. Genetic screening for CYpmidD6 in patients with these conditions may prevent life-threatening drug intoxication. Authors: Sato Akinori,Okura Yuji,Minagawa Shiroh,Ohno Yukiko,Fujita Satoru,Kondo Daisuke,Hayashi Manabu,Komura Satoru,Kato Kiminori,Hanawa Haruo,Kodama Makoto,Aizawa Yoshifusa, coumarin The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation Journal Am J Transplant Year 2004 Pages 914-9 Abstract: Previously, we reported that, at 3 months after renal transplantation, individuals with CYP3Apgkb genotype CYP3Apgkb*1 (linked to CYP3A5*1 and strongly associated with expression of CYP3A5) required twofold higher doses of tacrolimus to achieve target blood concentrations than individuals with the genotype CYP3Apgkb*3/*3 (CYP3A5 nonexpressors). This study assesses the relationship between concentration-controlled dosing during the early period after transplantation, the time to achieve target concentrations and genotype in 178 renal transplant recipients (CYP3Apgkb*1/*3 or *1/*1: n = 53, CYP3Apgkb*3/*3: n = 125). Patients with CYP3Apgkb*1/*3 or *1/*1 had lower mean tacrolimus concentrations during the first week (Median 13.5 vs. 18.5 microg/L, p < 0.0001) with significant delay in achieving target concentrations (15-20 microg/L during week 1, then 10-15 microg/L). More CYP3Apgkb*3/*3 patients had tacrolimus concentrations above target during the first week (73.6% vs. 35.8%, p = 0.003). There was no difference in the rate of biopsy-confirmed acute rejection, but rejection occurred earlier in the CYP3Apgkb*1/*3 or *1/*1 group (median 7 d vs. 13 d, p = 0.005). In conclusion, an initial dosing regimen for tacrolimus based on knowledge of the CYP3Apgkb genotype and subsequently guided by concentration measurements has the potential to increase the proportion of patients achieving target blood concentrations early after transplantation. Authors: MacPhee Iain A M,Fredericks Salim,Tai Tracy,Syrris Petros,Carter Nicholas D,Johnston Atholl,Goldberg Lawrence,Holt David W, beta adrenergic agonists formoterol Drug Trade Names:Foradil,Oxeze,Oxeze Turbuhaler,Oxeze Turbuhaler Foradil, erlotinib mianserin desmethylcitalopram levomepromazine eletriptan Drug Trade Names:Relpax, N-methyl-3,4,-methylenedioxymethamphetamine atomoxetine Drug Trade Names:Strattera, CYpmidD6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment Journal J Natl Cancer Inst Year 2005 Pages 30-9 Abstract: BACKGROUND: The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely among individuals. Plasma concentrations of the active tamoxifen metabolite endoxifen are associated with the cytochrome P450 (CYP) 2D6 genotype. We examined the effects of concomitant use of selective serotonin reuptake inhibitor antidepressants, which are CYpmidD6 enzyme inhibitors commonly prescribed to treat hot flashes in women who take tamoxifen, and genotypes for genes that encode tamoxifen-metabolizing enzymes on plasma concentrations of tamoxifen and its metabolites. METHODS: Eighty patients with newly diagnosed with breast cancer who were beginning tamoxifen therapy (20 mg/day orally), 24 of whom were taking CYpmidD6 inhibitors, were genotyped for common alleles of the CYpmidD6, CYpmidC9, CYP3A5, and sulfotransferase (SULT) 1A1 genes. Plasma concentrations of tamoxifen and its metabolites were measured after 1 and 4 months of tamoxifen therapy. Differences in plasma concentrations of tamoxifen and its metabolites between genotype groups were analyzed by the Wilcoxon rank sum test. All statistical tests were two-sided. RESULTS: Among all women, plasma endoxifen concentrations after 4 months of tamoxifen therapy were statistically significantly lower in subjects with a CYpmidD6 homozygous variant genotype (20.0 nM, 95% confidence interval [CI] = 11.1 to 28.9 nM) or a heterozygous genotype (43.1 nM, 95% CI = 33.3 to 52.9 nM) than in those with a homozygous wild-type genotype (78.0 nM, 95%CI = 65.9 to 90.1 nM) (both P = .003). Among subjects who carried a homozygous wild-type genotype, the mean plasma endoxifen concentration for those who were using CYpmidD6 inhibitors was 58% lower than that for those who were not (38.6 nM versus 91.4 nM, difference = -52.8 nM, 95% CI = -86.1 to -19.5 nM, P = .0025). The plasma endoxifen concentration was slightly reduced in women taking venlafaxine, a weak inhibitor of CYpmidD6, whereas the plasma endoxifen concentration was reduced substantially in subjects who took paroxetine (a potent inhibitor of CYpmidD6). Genetic variations of CYpmidC9, CYP3A5, or SULT1A1 had no statistically significant associations with plasma concentrations of tamoxifen or its metabolites. CONCLUSION: Interactions between CYpmidD6 polymorphisms and coadministered antidepressants and other drugs that are CYpmidD6 inhibitors may be associated with altered tamoxifen activity. Authors: Jin Yan,Desta Zeruesenay,Stearns Vered,Ward Bryan,Ho Herbert,Lee Kyung-Hoon,Skaar Todd,Storniolo Anna Maria,Li Lang,Araba Adjei,Blanchard Rebecca,Nguyen Anne,Ullmer Lynda,Hayden Jill,Lemler Suzanne,Weinshilboum Richard M,Rae James M,Hayes Daniel F,Flockhart David A, preeclampsia The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates Journal J Pharmacol Exp Ther Year 2005 Pages 1144-50 Abstract: Tamoxifen is effective in the prevention and treatment of breast cancer, but its use is associated with an increased risk of thrombosis. The mechanism for this effect is unknown. Reactive oxygen intermediates enhance platelet-dependent thrombosis, and in oncological studies, tamoxifen has been shown to increase production of reactive oxygen species. Therefore, the effects of tamoxifen and its bioactive metabolites on platelet activity and platelet reactive oxygen species were determined. Platelets were incubated with tamoxifen or the metabolites 4-hydroxy-tamoxifen (4-OH), N-desmethyl tamoxifen, or 4-hydroxy-N-desmethyl tamoxifen (endoxifen). Tamoxifen metabolites have been previously shown to possess enhanced bioactivity, and consistent with this observation, tamoxifen metabolites but not tamoxifen modestly increased platelet aggregation. These effects were similar with platelets isolated from male or female subjects. Platelet nitric oxide release or cGMP levels were not altered by incubation with tamoxifen or any of its metabolites. Incubation with tamoxifen metabolites increased stimulation-dependent platelet superoxide release [8.1 +/- 1.6 arbitrary units (a.u.) for control versus 15.2 +/- 3.5 a.u. for 4-OH; P < 0.01]. Coincubation with a superoxide dismutase mimetic eliminated the tamoxifen metabolite-induced enhancement of platelet aggregation. Corresponding to increased superoxide release, incubation with tamoxifen metabolites enhanced the functional activation of NADPH oxidase as determined by phosphorylation of its subunits p47(phox) and p67(phox). In summary, incubation of platelets with the active metabolites of tamoxifen increases stimulation-dependent superoxide release through a NADPH oxidase-dependent mechanism. This results in modest changes in platelet function and seems to be consistent with previous oncological studies demonstrating tamoxifen-dependent increase in reactive oxygen species generation. Authors: Vitseva Olga,Flockhart David A,Jin Yan,Varghese Sonia,Freedman Jane E, domperidone Drug Trade Names:Motilium, fidlblast growth factor receptor substrate 2 Gene Symbol: FRS2 Gene Alternate Names: FGFR signalling adaptor,FRS2A,FRS2alpha,SNT-1,SNT1,suc1-associated neurotrophic factor target, Gene Alternate Symbols: FRS2A,FRS2alpha,SNT,SNT-1,SNT1, Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians Journal Transplantation Year 2005 Pages 499-502 Abstract: Previously, we demonstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was associated with a single nucleotide polymorphism (SNP) in the CYP3Apgkb gene, probably through linkage with an SNP in the CYP3A5 gene. Individuals with at least one CYP3A5*1 allele synthesize CYP3A5 and CYP3A5*3/*3 homozygotes do not. We now present results with direct typing of the CYP3A5 genotype for this group of 180 kidney-only transplant recipients from a single center. South Asian and white patients with at least one CYP3A5*1 allele achieved twofold lower dose-normalized tacrolimus blood concentrations compared with CYP3A5*3/*3 homozygotes, confirming our previous findings for the CYP3Apgkb SNP. There was a significant delay in achieving target blood concentrations in those with at least one CYP3A5*1 allele. Determination of the CYP3A5*1/*3 genotype could be used to predict the tacrolimus dose requirement and, given incomplete linkage, would be better than determination of the CYP3Apgkb genotype. Authors: Macphee Iain A M,Fredericks Salim,Mohamed Maha,Moreton Michelle,Carter Nicholas D,Johnston Atholl,Goldberg Lawrence,Holt David W, Transplantation solute carrier organic anion transporter family, member 1B1 Gene Symbol: SLCO1B1 Gene Alternate Names: LST-1,OATP-C,OATpgkbB1,solute carrier family 21 (organic anion transporter), member 6, Gene Alternate Symbols: LST-1,MGC133282,OATP-C,OATpgkbB1,OATpmid,SLC21A6, CDK5 regulatory subunit associated protein 1-like 1 Gene Symbol: CDKAL1 Gene Alternate Names: FLJ20342, Gene Alternate Symbols: FLJ20342,FLJ46705,MGC75469, phospholipase C, zeta 1 Gene Symbol: PLCZ1 Gene Alternate Names: NYD-Spmid7,PI-phospholipase C zeta 1,testis-development related NYD-Spmid7, Gene Alternate Symbols: NYD-Spmid7,PLCzeta, chromosome 10 open reading frame 61 Gene Symbol: C10orf61 Gene Alternate Names: DKFZP564D116,OTTHUMP00000059383, Gene Alternate Symbols: DKFZP564D116,DKFZp564D116,TECT3, pre-B-cell colony enhancing factor 1 Gene Symbol: PBEF1 Gene Alternate Names: 1110035O14Rik,H_NH0022N19_gi18089094.sp_cds.1,pre-B-cell colony-enhancing factor, Gene Alternate Symbols: 1110035O14Rik,DKFZP666B131,MGC117256,NAMPT,PBEF, NADPH dependent diflavin oxidoreductase 1 Gene Symbol: NDOR1 Gene Alternate Names: NADPH-dependent FMN and FAD containing oxidoreductase,NR1,OTTHUMP00000064742,Rpgkb1-350O14.11,bA350O14.9, Gene Alternate Symbols: MGC138148,NR1,bA350O14.9, RNA binding motif protein 19 Gene Symbol: RBM19 Gene Alternate Names: DKFZp586F1023,KIAA0682, Gene Alternate Symbols: DKFZp586F1023,KIAA0682,NPO, phosphoinositide-3-kinase, regulatory subunit 5, pgkb01 Gene Symbol: PIK3R5 Gene Alternate Names: F730038I15Rik,pgkb01-PI3K,phosphoinositide-3-kinase, regulatory subunit, polypeptide pgkb01, Gene Alternate Symbols: F730038I15Rik,FOAP-2,pgkb01-PI3K, arsenic (+3 oxidation state) methyltransferase Gene Symbol: AS3MT Gene Alternate Names: 2310045H08Rik,Arsenic Methyltransferase,CYT19,Cyt19 protein,S-adenosylmethionine:arsenic (III) methyltransferase, Gene Alternate Symbols: 2310045H08Rik,AsMT,CYT19, ankyrin repeat domain 12 Gene Symbol: ANKRD12 Gene Alternate Names: FLJ20053,GAC-1,KIAA0874, Gene Alternate Symbols: ANCO-2,FLJ20053,GAC-1,KIAA0874,Nbla00144, microRNA 208 Gene Symbol: MIRN208 Gene Alternate Names: hsa-mir-208, Gene Alternate Symbols: hsa-mir-208, phospholipase C, eta 2 Gene Symbol: PLCH2 Gene Alternate Names: KIAA0450,RP3-395M20.1,phospholipase C-like 4, Gene Alternate Symbols: KIAA0450,PLC-eta2,PLCL4,PLCeta2,RP3-395M20.1, solute carrier family 30 (zinc transporter), member 8 Gene Symbol: SLC30A8 Gene Alternate Names: zinc transporter ZnT-8, Gene Alternate Symbols: ZnT-8, ring finger and WD repeat domain 2 Gene Symbol: RFWD2 Gene Alternate Names: COpgkb,FLJ10416,OTTHUMP00000060611,Rpgkb1-318C24.3,constitutive photomorphogenic protein,constitutive photomorphogenic protein (COpgkb), Gene Alternate Symbols: COpgkb,FLJ10416,RNF200, myosin, heavy polypeptide 15 Gene Symbol: MYH15 Gene Alternate Names: KIAA1000, Gene Alternate Symbols: KIAA1000, purinergic receptor pmidY, G-protein coupled, 12 Gene Symbol: pmidRY12 Gene Alternate Names: ADP-glucose receptor,G-protein coupled receptor Spgkb999,Gi-coupled ADP receptor HORK3,HORK3,pmidY purinoceptor 12,pmidY12,Spgkb999,platelet ADP receptor,purinergic receptor pmidRY12,purinergic receptor pmidY, G-protein coupled 12,putative G-protein coupled receptor, Gene Alternate Symbols: ADPG-R,HORK3,pmidT(AC),pmidY(AC),pmidY(ADP),pmidY(cyc),pmidY12,Spgkb999, kallikrein 15 Gene Symbol: KLK15 Gene Alternate Names: ACO,ACO protease,HSRNASPH,kallikrein-like serine protease,prostinogen, Gene Alternate Symbols: ACO,HSRNASPH,prostinogen, deoxycytidine kinase Gene Symbol: DCK Gene Alternate Symbols: MGC117410,MGC138632, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Gene Symbol: ACE Gene Alternate Names: ACE1,CD143,CD143 antigen,angiotensin converting enzyme, somatic isoform,carboxycathepsin,dipeptidyl carboxypeptidase 1,dipeptidyl carboxypeptidase 1 (angiotensin I converting enzyme),kininase II,peptidase P,peptidyl-dipeptidase A,testicular ECA, Gene Alternate Symbols: ACE1,CD143,DCP,DCpgkb,MGC26566, dopa decarboxylase (aromatic L-amino acid decarboxylase) Gene Symbol: DDC Gene Alternate Names: aromatic L-amino acid decarboxylase, Gene Alternate Symbols: AADC, Methotrxate, Merceptapurine Lymphoblastic Leukemia, Acute L1 pitavastatin Impact of CYpmidD6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study Journal Clin Pharmacol Ther Year 2005 Pages 378-87 Abstract: OBJECTIVE: Our objective was to study the impact of the cytochrome P450 (CYP) 2D6 polymorphism on the tolerability of metoprolol in a real-life primary care setting. The adverse effects studied comprised effects related to the central nervous system, cardiovascular effects, and sexual dysfunction. METHODS: Patients in whom treatment with metoprolol was considered were enrolled into this prospective, 6-week multicenter study. The dosage of metoprolol was determined on an individual basis and could be freely adjusted on clinical grounds. The indication for treatment was hypertension in about 90% of cases. Systolic and diastolic blood pressure, resting heart rate, and plasma metoprolol and alpha-hydroxymetoprolol concentrations were measured. CYpmidD6 genotyping covered alleles *3 to *10 and *41 and the duplications. Possible adverse effects of metoprolol were systematically assessed over a 6-week period by means of standardized rating scales and questionnaires. RESULTS: The final study population comprised 121 evaluable patients (all white patients); among them, there were 5 ultrarapid metabolizers (UMs) (4.1%), 91 extensive metabolizers (EMs) (75%), 21 intermediate metabolizers (IMs) (17%), and 4 poor metabolizers (PMs) (3.3%). Plasma metoprolol concentrations normalized for the daily dose and metoprolol/alpha-hydroxymetoprolol ratios at steady state were markedly influenced by CYpmidD6 genotype and displayed a gene-dose effect. The median of the dose-normalized metoprolol concentration was 0.0088 ng/mL, 0.047 ng/mL, 0.34 ng/mL, and 1.34 ng/mL among UMs, EMs, IMs, and PMs, respectively (P<.0001). There was no significant association between CYpmidD6 genotype-derived phenotype (EMs and UMs combined versus PMs and IMs combined) and adverse effects during treatment with metoprolol. There was a tendency toward a more frequent occurrence of cold extremities in the PM plus IM group as compared with the EM plus UM group (16.0% versus 4.2%, P=.056; relative risk, 3.8 [95% confidence interval, 1.03--14.3]). CONCLUSIONS: CYpmidD6 genotype-derived phenotype was not significantly associated with a propensity for adverse effects to develop during treatment with metoprolol. However, the results concerning tolerability of metoprolol in PMs were inconclusive because of the small number of PMs enrolled. Authors: Fux Richard,M�rike Klaus,Pr�hmer Anne M T,Delabar Ursula,Schwab Matthias,Schaeffeler Elke,Lorenz Gernot,Gleiter Christoph H,Eichelbaum Michel,Kivist� Kari T, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 Gene Symbol: SULT1A4 hexoprenaline dihydrofolate reductase Gene Symbol: DHFR methotrexate, 5-fluorouracil MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists Journal Clin Pharmacol Ther Year 2006 Pages 62-71 Abstract: BACKGROUND: Gingival overgrowth is a common side effect of calcium antagonists. Although the pathogenesis is unknown, several lines of evidence point to a modulation of inflammatory processes. Because the calcium antagonists, albeit to a variable degree, act as inhibitors of P-glycoprotein (P-gp), the gene product of multidrug resistance 1 (MDR1), and inflammation may modify P-gp expression, we analyzed the MDR1 polymorphisms as risk factors for gingival overgrowth induced by calcium antagonists. METHODS: Clinical, laboratory, and anamnestic data including periodontal parameters and use of calcium antagonists were assessed in a cross-sectional epidemiologic investigation (N = 1484). MDR1 polymorphisms in exon 21 G2677T/A and exon 26 C3435T were determined. P-gp expression was detected in gingival tissues. In a matched-pair analysis, 93 subjects using calcium antagonists and 186 not using them were compared. RESULTS: P-gp is expressed in the endothelial layers of blood vessels obtained from healthy or inflamed gingiva. Subjects treated with calcium antagonists had significantly deeper gingival pockets than their drug-free counterparts (P <.0001). This drug-related side effect was associated with the MDR1 2677G/G or G/TA genotype (P <.001) but not with the variant genotype T/TA. This drug effect was proved by multiple regression analysis with adjustment for the risk factors of periodontitis (age, sex, smoking, and education) (P <.0001) and was associated with elevated C-reactive protein levels. The association of probing depth with the MDR1 polymorphism was confirmed in the matched-pair analysis (P <.0001). CONCLUSION: Treatment with calcium antagonists leads to gingival hyperplasia, which is associated with the MDR1 G2677T/A polymorphism. The MDR1 genotype may modify the inflammatory response to the drugs. Authors: Meisel Peter,Giebel J�rgen,Kunert-Keil Christiane,Dazert Peter,Kroemer Heyo K,Kocher Thomas, Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients Journal Clin Pharmacol Ther Year 2006 Pages 90-102 Abstract: BACKGROUND: Although the prevention of immunologic reactions with sufficient immunosuppression prolongs graft and patient survival rates, the large interindividual variation in tacrolimus pharmacokinetics interferes with treatment. In this study we have examined whether intestinal MDR1 (ABCB1) is a potential biomarker predicting the occurrence of acute cellular rejection, as well as a factor to predict absorption of tacrolimus, after living-donor liver transplantation. METHODS: By use of tissue specimens of intestinal mucosa (n = 164) obtained at surgery, the messenger ribonucleic acid (mRNA) expression of intestinal MDR1 and cytochrome P450 (CYP) 3A4 was quantified. RESULTS: The probability of acute cellular rejection during the first 10 days after surgery was significantly associated with the average trough concentration of tacrolimus between postoperative days 2 and 4 (45.1% for <7 ng/mL versus 22.9% for >7 ng/mL,P= .0040). High levels of MDR1 were associated with an episode of acute cellular rejection before postoperative day 10 (odds ratio, 2.306 [95% confidence interval, 1.058-5.028]) and with a poor survival rate during the first postoperative year (odds ratio, 7.413 [95% confidence interval, 1.567-36.073]). The mRNA expression level of MDR1 was inversely correlated with the tacrolimus concentration-oral dose ratio during the initial 4 days after surgery in patients with a graft-to-recipient weight ratio greater than 1.5 (r= -0.6798, P< .0001) and those with a graft-to-recipient weight ratio of less than 1.5 (r= -0.7180, P< .0001). CONCLUSION: The enterocyte MDR1 mRNA level was suggested to be a risk factor for acute cellular rejection and death after surgery. Therefore obtaining a sufficient tacrolimus blood level via this molecular information-based initial dosage adjustment may enable the episode of acute cellular rejection after liver transplantation to be reduced. Authors: Masuda Satohiro,Goto Maki,Fukatsu Sachio,Uesugi Miwa,Ogura Yasuhiro,Oike Fumitaka,Kiuchi Tetsuya,Takada Yasutsugu,Tanaka Koichi,Inui Ken-Ichi, 6-mercaptopurine, azathioprine protease inhibitors anticonvulsants dihydropyrimidine dehydrogenase Gene Symbol: DPYD Gene Alternate Names: OTTHUMP00000058954, Gene Alternate Symbols: DHP,DPD,MGC132008,MGC70799, Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia Journal Eur J Cancer Year 2006 Pages 2893-6 Abstract: Here, we evaluated the relationships between ABCB1 (P-glycoprotein, MDR1) polymorphisms and paclitaxel (Taxol)-induced toxicity and pharmacokinetics. Twenty-six patients were assessable for pharmacogenetics and pharmacokinetics, 22 for neurotoxicity and 18 for myelotoxicity. Patients carrying two reference alleles for the ABCB1 3435C>T polymorphism trended toward a reduced risk to develop neuropathy as compared to patients carrying at least one variant allele (P=0.09). Additionally, patients who were homozygous variant at the 2677 and 3435 loci had a significantly greater percent decrease in absolute neutrophil count at nadir (P=0.02). Neither polymorphism correlated with paclitaxel pharmacokinetics. This pilot study suggests that paclitaxel-induced neuropathy and neutropenia might be linked to inherited variants of ABCB1 through a mechanism that is unrelated to altered plasma pharmacokinetics. Authors: Sissung Tristan M,Mross Klaus,Steinberg Seth M,Behringer Dirk,Figg William D,Sparreboom Alex,Mielke Stephan, dopamine receptor D1 Gene Symbol: DRD1 Gene Alternate Symbols: DADR,DRD1A, nonnucleoside reverse-transcriptase inhibitors N2-O6 alkylator N7 alkylator topoisomerase i inhibitors antifolates vinca-alkaloids taxanes The use of low dose methotrexate in rheumatoid arthritis - are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Journal Biomed Pharmacother Year 2006 Pages 678-87 Abstract: Methotrexate (MTX) is one of the most commonly used medications in the treatment of rheumatoid arthritis (RA). It has proven efficacy as a sole agent as well as in combination with other disease modifying anti-rheumatic agents (DMARDs) including the newer biological agents. MTX is generally well tolerated although there are a number of potentially serious adverse effects. Of these, haematopoietic suppression, hepatotoxicity and pulmonary toxicity are the more severe and patients are therefore required to have appropriate monitoring while they remain on MTX. In the past, attempts at therapeutic drug monitoring using serum MTX concentrations have been unsuccessful. However, MTX is taken into red blood cells (RBC) where up to four glutamates are added to form MTX polyglutamates (MTXPG(n)). More recently it has been suggested that higher RBC MTXPG(3-5) concentrations may be associated with improved disease control. Genetic variations in enzymes involved in the uptake of MTX into cells and its metabolism are also being examined for their ability to predict drug response and potential for adverse events. While it is unlikely that a single genetic variant will predict efficacy or toxicity there is preliminary evidence that a "pharmacogenetic index" that takes into account the effects of multiple genetic variants maybe useful. Although in their infancy at present, both therapeutic drug monitoring using MTXPG concentrations and pharmacogenomics of MTX may prove useful in the future and are worthy of further investigation. Authors: Stamp Lisa,Roberts Rebecca,Kennedy Martin,Barclay Murray,O'Donnell John,Chapman Peter, CYpmidD6 polymorphism and clinical effect of the antidepressant venlafaxine Journal J Clin Pharm Ther Year 2006 Pages 493-502 Abstract: BACKGROUND: Venlafaxine (V) is a mixed serotonin and noradrenaline reuptake inhibitor used as a first-line treatment of depressive disorders. It is metabolized primarily by the highly polymorphic cytochrome P450 (CYP) enzyme CYpmidD6 to yield a pharmacologically active metabolite, O-desmethylvenlafaxine (ODV), and to a lesser extent by CYP3A4, to yield N-desmethylvenlafaxine (NDV). Objectives: The aim of this study was to assess whether the O-demethylation phenotype of V has an impact on the pharmacokinetics and clinical outcome. METHOD: In 100 patients treated with V, serum concentrations of V, ODV and NDV and the ratios of concentrations ODV/V as a measure of O-demethylation were determined. Individuals exhibiting abnormally high or low metabolic ratios of ODV/V were selected for genotyping. Clinical effects were monitored by the Clinical Global Impressions Scale and side effects by the UKU (Udvalg for Kliniske Undersogelser Side Effect Rating Scale) rating scale. RESULTS: There was wide inter-individual variability in ODV/V ratios. The median ratio ODV/V was 1.8 and the 10th and 90th percentiles 0.3 and 5.2, respectively. Individuals with ODV/V ratios below 0.3 were all identified as poor metabolizers (PM), with the genotypes *6/*4 (n = 1), *5/*4 (n = 2) or *6/*6 (n = 1). Individuals with ratios above 5.2 were all ultra rapid metabolizers (UM, n = 6) due to gene duplications. Five individuals with intermediate metabolic activity (ODV/V, 1.1 +/- 0.8) were heterozygotes with the CYpmidD6*4 genotype, and one patient with an intermediate metabolic ratio of 4.8 had the genotype *4/2x*1. Clinical outcome measurements revealed that patients with ODV/V ratios below 0.3 had more side effects (P < 0.005) and reduced serum concentrations of sodium (P < 0.05) in comparison with other patients. Gastrointestinal side effects, notably nausea, vomiting and diarrhoea were the most common. Differences in therapeutic efficacy were not significant between the different phenotypes. CONCLUSION: The O-demethylation phenotype of V depends strongly on the CYpmidD6 genotype. A PM phenotype of CYpmidD6 increases the risk of side effects. Authors: Shams M E E,Arneth B,Hiemke C,Dragicevic A,M�ller M J,Kaiser R,Lackner K,H�rtter S, diuretics Ancestry and pharmacogenetics of antileukemic drug toxicity Journal Blood Year 2007 Abstract: Treatment-related toxicity in acute lymphoblastic leukemia (ALL) cannot only be life-threatening but may affect relapse risk. In 240 patients, we determined whether toxicities were related to 16 polymorphisms in genes linked to the pharmacodynamics of ALL chemotherapy, adjusting for age, race (self-reported or via ancestry-informative markers), sex and disease risk group (lower vs. higher-risk therapy). Toxicities (gastrointestinal, infectious, hepatic, and neurological) were assessed in each treatment phase. During the induction phase, when drugs subject to the steroid/cytochrome P4503A pathway predominated, genotypes in that pathway were important: vitamin D receptor (odds ratio [OR] 6.85 [95% confidence interval 1.73-27.0]) and cytochrome P4503A5 (OR 4.61 [1.11-19.2]) polymorphisms were related to gastrointestinal toxicity and infection, respectively. During the consolidation phase, when antifolates predominated, the reduced folate carrier polymorphism predicted gastrointestinal toxicity (OR 10.4 [1.35-80.4]) as it also did during continuation (OR 2.01 [1.06-4.11]). In all three treatment phases, a glucuronosyltransferase polymorphism predicted hyperbilirubinemia (p = 0.017, < 0.0001, and < 0.0001, respectively) and methotrexate clearance (p = 0.028), which was also independently associated with hyperbilirubinemia (p = 0.026). The genotype-phenotype associations were similar whether analyses were adjusted by self-reported race or ancestry-informative genetic markers. Germline polymorphisms are significant determinants of toxicity of antileukemic therapy. Authors: Kishi Shinji,Cheng Cheng,French Deborah,Pei Deqing,Das Soma,Cook Edwin H,Hijiya Nobuko,Rizzari Carmelo,Rosner Gary L,Frudakis Tony,Pui Ching-Hon,Evans William E,Relling Mary V, Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension Journal Clin Pharmacol Ther Year 2006 Pages 633-45 Abstract: OBJECTIVES: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. beta(2)-Adrenergic receptors (beta(2)ARs) are up-regulated in hypertension and largely polymorphic within the human population. Recently, we have shown that the Glu27 beta(2)AR variant is strongly associated with cardiac hypertrophy in hypertension. The objective of this study is to verify whether this polymorphism also affects hypertrophy regression in response to antihypertensive therapy. METHODS: In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile beta(2)AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. Results were stratified according to treatment and the Glu27Gln polymorphism of the beta(2)AR. In cells with stable overexpression of the Glu27 or Gln27 variant of beta(2)AR, we also explored the implications of this polymorphism on hypertrophy-related intracellular signal transduction. RESULTS: Among hypertensive patients, the Gly16 allele was found in 63% of patients and the Glu27 allele was found in 40.6%. Both polymorphisms were in linkage disequilibrium, as expected. Four hundred forty-one hypertrophic hypertensive patients completed the 2-year follow-up. At baseline, patients carrying at least 1 allele of the Glu27 variant presented with a larger cardiac size despite similar blood pressure levels (142.9 +/- 22.5 g/m(2) in Glu27 carriers versus 138.2 +/- 18.4 g/m(2) in Gln27 carriers, P < .02). Blood pressure normalization was achieved by both drugs. At follow-up, compared with the Gln27 patients, the Glu27 patients showed a larger reduction in hypertrophy when treated with enalapril (percent change in left ventricular mass, -6.3% +/- 7.7% in Glu27 carriers versus -2.18% +/- 7.9% in Gln27 carriers; P < .05) but not with atenolol therapy (-2.8% +/- 8.9% in Glu27 carriers versus -2.4% +/- 8.8% in Gln27 carriers, P = not significant). In in vitro studies the activation of p38 and extracellular signal-regulated kinase (ERK-) 1/2 (data not shown) and the activity of the atrial natriuretic factor (ANF) promoter after isoproterenol (INN, isoprenaline) stimulation were larger in Glu27 beta(2)AR overexpressing cells than in Gln27 beta(2)AR overexpressing cells (fold difference compared with unstimulated cells, 9.7 +/- 2.9 for Glu27 beta(2)AR versus 4.2 +/- 0.3 for Gln27 beta(2)AR; P < .05). CONCLUSIONS: The Glu27 variant of beta(2)AR enhances hypertension-induced left ventricular hypertrophy. In these patients angiotensin-converting enzyme inhibitors are more efficient than beta-blockers in reducing cardiac size. Authors: Iaccarino Guido,Izzo Raffaele,Trimarco Valentina,Cipolletta Ersilia,Lanni Francesca,Sorriento Daniela,Iovino Gianni Luigi,Rozza Francesco,De Luca Nicola,Priante Ornella,Di Renzo Gianfranco,Trimarco Bruno, dextramethorphan Death, Neonatal grapefruit juice naringin naringenin 6,7-dihydroxybergamottin fluorodeoxyuridine neuropsychiatric medications nebivolol Esophogeal Neoplasms 4-methylthioamphetamine E2F transcription factor 1 Gene Symbol: E2F1 Gene Alternate Names: retinoblastoma-associated protein 1, Gene Alternate Symbols: E2F-1,RBBP3,RBP3, geldanamycin Clopidogrel pharmacogenetics: promising steps towards patient care? Journal Arterioscler Thromb Vasc Biol Year 2006 Pages 1681-3 Abstract: null Authors: Beitelshees Amber L,McLeod Howard L, Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence Journal Am J Hum Genet Year 2006 Pages 973-87 Abstract: The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and alcohol dependence (AD) have long been studied in many populations, but not comprehensively. In the present study, we genotyped 16 markers within the ADH gene cluster (including the ADH1A, ADH1B, ADH1C, ADH5, ADH6, and ADH7 genes), 4 markers within the ALDH2 gene, and 38 unlinked ancestry-informative markers in a case-control sample of 801 individuals. Associations between markers and disease were analyzed by a Hardy-Weinberg equilibrium (HWE) test, a conventional case-control comparison, a structured association analysis, and a novel diplotype trend regression (DTR) analysis. Finally, the dl:Disease alleles were fine mapped by a Hardy-Weinberg disequilibrium (HWD) measure (J). All markers were found to be in HWE in controls, but some markers showed HWD in cases. Genotypes of many markers were associated with AD. DTR analysis showed that ADH5 genotypes and diplotypes of ADH1A, ADH1B, ADH7, and ALDH2 were associated with AD in European Americans and/or African Americans. The risk-influencing alleles were fine mapped from among the markers studied and were found to coincide with some well-known functional variants. We demonstrated that DTR was more powerful than many other conventional association methods. We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes. Authors: Luo Xingguang,Kranzler Henry R,Zuo Lingjun,Wang Shuang,Schork Nicholas J,Gelernter Joel, fat mass and obesity associated Gene Symbol: FTO Gene Alternate Symbols: KIAA1752,MGC5149, Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action Journal J Clin Invest Year 2007 Pages 1422-1431 Abstract: Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is unknown. Recent studies have shown that human OCT1 is highly polymorphic. We investigated whether OCT1 plays a role in the action of metformin and whether individuals with OCT1 polymorphisms have reduced response to the drug. In mouse hepatocytes, deletion of Oct1 resulted in a reduction in the effects of metformin on AMPK phosphorylation and gluconeogenesis. In Oct1-deficient mice the glucose-lowering effects of metformin were completely abolished. Seven nonsynonymous polymorphisms of OCT1 that exhibited reduced uptake of metformin were identified. Notably, OCT1-420del (allele frequency of about 20% in white Americans), previously shown to have normal activity for model substrates, had reduced activity for metformin. In 7 studies, the effects of metformin in glucose tolerance tests were significantly lower in individuals carrying reduced function polymorphisms of OCT1. Collectively, the data indicate that OCT1 is important for metformin therapeutic action and that genetic variation in OCT1 may contribute to variation in response to the drug. Authors: Shu Yan,Sheardown Steven A,dlwn Chaline,Owen Ryan P,Zhang Shuzhong,Castro Richard A,Ianculescu Alexandra G,Yue Lin,Lo Joan C,Burchard Esteban G,Brett Claire M,Giacomini Kathleen M, A phase II study of irinotecan and carboplatin in advanced non-small cell lung cancer with pharmacogenomic analysis: final report Journal J Thorac Oncol Year 2006 Pages 972-8 Abstract: PURPOSE: We conducted a phase II study of carboplatin and irinotecan in patients with advanced non-small cell lung cancer (NSCLC). In addition, we studied the correlation between certain genotypes of enzymes involved in irinotecan metabolism with efficacy and toxicity. PATIENTS AND METHODS: Patients with stage IIIB, IV, or recurrent NSCLC received a combination of irinotecan and carboplatin every 3 weeks at a dose of 200 mg/m2 and area under the curve of 5. Pharmacogenomic analysis was performed on several genes of interest (ABCB1, CYP3A4*1B, ERCC2, GSTpgkb, UGT1A1*28, and XRCC1). RESULTS: Forty-two patients enrolled between December 2001 and January 2004. Six patients achieved partial responses (14%), and 19 (45%) had stable dl:Disease. The median progression-free survival was 6.9 months. The median overall survival was 11.7 months, with 1-year overall survival of 42%. The most common toxicities were hematologic; grade 3 or 4 neutropenia was experienced by 26 patients (62%) during treatment, and 15 patients (36%) experienced grade 3 or 4 thrombocytopenia. The homozygous UGT1A1*28 (7/7) genotype was associated with grade 4 neutropenia in three of four patients (75%), but only eight out of 30 (27%) with 6/6 or 6/7 genotypes experienced grade 4 neutropenia (p = 0.09). None of the 14 patients with the GSTpgkb I105V A/A genotype had a partial response, as opposed to five out of 19 (26%) of those with the G/A or G/G genotypes (p = 0.057). CONCLUSION: The combination of carboplatin and irinotecan is an active combination in NSCLC, with response rates comparable with other platinum-containing doublets. Further studies with irinotecan should incorporate prospective pharmacogenomic analysis to identify markers for response and toxicity. Authors: Pillot Giancarlo A,Read William L,Hennenfent Kristin L,Marsh Sharon,Gao Feng,Viswanathan Avinash,Cummings Kristopher,McLeod Howard L,Govindan Ramaswamy, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) Gene Symbol: ERCC1 Gene Alternate Names: Excision repair cross complementing rodent repair deficiency,,excision repair protein, Gene Alternate Symbols: UV20, estrogen receptor 1 Gene Symbol: ESR1 Gene Alternate Names: Era,NR3A1,dJ443C4.1.1 (estrogen receptor 1),estrogen receptor 1 (alpha),major ORF,steroid hormone receptor, Gene Alternate Symbols: DKFZp686N23123,ER,ESR,ESRA,Era,NR3A1,major ORF, folylpolyglutamate synthase Gene Symbol: FPGS Gene Alternate Names: Folylpolyglutamate synthetase,folylpolyglutamate synthetase, GNAS complex locus Gene Symbol: GNAS Gene Alternate Names: G-s-alpha,GNASXL,GPSA,NESP,NESP55,adenylate cyclase-stimulating G alpha protein,dJ309F20.1.1 (paternally expressed G protein XL alpha s),dJ806M20.3.3 (neuroendocrine secretory protein 55 (NESP55)),guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1,guanine nucleotide regulatory protein,neuroendocrine secretory protein 55,neuroendocrine-specific Golgi protein p55,paternally expressed G protein XL alpha S, Gene Alternate Symbols: AHO,C20orf45,GNAS1,GNASXL,GPSA,GSA,GSP,MGC33735,NESP,NESP55,PHpgkbA,PHpgkbB,POH,SCG6,XL,XL2,XLalphas,dJ309F20.1.1,dJ806M20.3.3, guanine nucleotide binding protein (G protein), beta polypeptide 3 Gene Symbol: GNB3 Gene Alternate Names: G protein, beta-3 subunit,GTP-binding regulatory protein beta-3 chain,guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3,hypertension associated protein,transducin beta chain 3, N-acetyltransferase 2 (arylamine N-acetyltransferase) Gene Symbol: NAT2 Gene Alternate Names: Arylamine N-acetyltransferase-2,arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation), Gene Alternate Symbols: AAC2, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Gene Symbol: NR3C1 Gene Alternate Names: GR,Glucocorticoid receptor, lymphocyte,glucocorticoid receptor,nuclear receptor subfamily 3, group C, member 1, Gene Alternate Symbols: GCCR,GCR,GR,GRL, glutathione S-transferase M1 Gene Symbol: GSTM1 Gene Alternate Names: GST class-mu 1,H-B,HB subunit 4,S-(hydroxyalkyl)glutathione lyase,glutathione S-alkyltransferase,glutathione S-aralkyltransferase,glutathione S-aryltransferase,glutathione S-transferase, Mu-1, Gene Alternate Symbols: GST1,GSTM1-1,GSTM1a-1a,GSTM1b-1b,GTH4,GTM1,H-B,MGC26563,MU,MU-1, glutathione S-transferase theta 1 Gene Symbol: GSTT1 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) Gene Symbol: ACAT2 Gene Alternate Names: acetoacetyl Coenzyme A thiolase, histamine N-methyltransferase Gene Symbol: HNMT Gene Alternate Symbols: HMT,HNMT-S1,HNMT-S2, 5-hydroxytryptamine (serotonin) receptor 1A Gene Symbol: HTR1A Gene Alternate Names: 5-HT1A,5-HT1a receptor,G protein coupled receptor,guanine nucleotide-binding regulatory protein-coupled receptor, Gene Alternate Symbols: 5-HT1A,ADRB2RL1,ADRBRL1, 5-hydroxytryptamine (serotonin) receptor 2A Gene Symbol: HTR2A Gene Alternate Names: 5-HT2 receptor,5-HT2A, Gene Alternate Symbols: 5-HT2A,HTR2, 5-hydroxytryptamine (serotonin) receptor 2C Gene Symbol: HTR2C Gene Alternate Names: 5-HT2C, Gene Alternate Symbols: 5-HT2C,HTR1C, interleukin 6 (interferon, beta 2) Gene Symbol: IL6 Gene Alternate Symbols: BSF2,HGF,HSF,IFNB2,IL-6, interleukin 13 Gene Symbol: IL13 Gene Alternate Symbols: ALRH,BHR1,IL-13,MGC116786,MGC116788,MGC116789,P600, APEX nuclease (multifunctional DNA repair enzyme) 1 Gene Symbol: APEX1 Gene Alternate Names: AP endonuclease class I,AP lyase,APEX nuclease (multifunctional DNA repair enzyme),DNA-(apurinic or apyrimidinic site) lyase,apurinic/apyrimidinic (abasic) endonuclease,apurinic/apyrimidinic exonuclease,deoxyribonuclease (apurinic or apyrimidinic),multifunctional DNA repair enzyme, Gene Alternate Symbols: APE,APE1,APEN,APEX,APX,HApgkb,REF-1,REF1, ADP-ribosylation factor GTPase activating protein 1 Gene Symbol: ARFGApgkb Gene Alternate Names: ADP-ribosylation factor 1 GTPase activating protein,ARF1-directed GTPase-activating protein,GAP protein, Gene Alternate Symbols: ARF1GAP,Arf GApgkb,FLJ10767,HRIHFB2281,MGC39924,bA261N11.3, insulin receptor substrate 1 Gene Symbol: IRS1 Gene Alternate Symbols: HIRS-1, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Gene Symbol: ITGB3 Gene Alternate Names: platelet glycoprotein IIIa precursor, Gene Alternate Symbols: CD61,GP3A,GPIIIa, potassium inwardly-rectifying channel, subfamily J, member 11 Gene Symbol: KCNJ11 Gene Alternate Names: ATP-sensitive inward rectifier potassium channel 11,Kir6.2,beta-cell inward rectifier subunit,inwardly rectifying potassium channel KIR6.2, Gene Alternate Symbols: BIR,HHF2,IKATP,KIR6.2,Kir6.2,MGC133230,PHHI, kininogen 1 Gene Symbol: KNG1 Gene Alternate Names: alpha-2-thiol proteinase inhibitor,bradykinin,kininogen, Gene Alternate Symbols: BDK,KNG,kininogen, leptin receptor Gene Symbol: LEPR Gene Alternate Names: OB receptor, Gene Alternate Symbols: CD295,OBR, O-6-methylguanine-DNA methyltransferase Gene Symbol: MGMT Gene Alternate Names: Methylguanine-DNA methyltransferase, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) Gene Symbol: MLH1 Gene Alternate Names: DNA mismatch repair protein Mlh1,HNPCC,mutL (E. coli) homolog 1,mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2), Gene Alternate Symbols: COCA2,FCC2,HNPCC,HNPCC2,MGC5172,hMLH1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) Gene Symbol: MLL Gene Alternate Names: ALL-1,CXXC7,HRX,HTRX1,MLL protein,Myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila),TRX1,myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog),trithorax-like protein,zinc finger protein HRX, Gene Alternate Symbols: ALL-1,CXXC7,HRX,HTRX1,MLL1A,TRX1, myeloperoxidase Gene Symbol: MPO septin 3 Gene Symbol: SEPT3 Gene Alternate Names: neuronal-specific septin 3, Gene Alternate Symbols: MGC133218,SEP3,bK250D10.3, ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Gene Symbol: ABCC1 Gene Alternate Names: GS-X,Human multidrug resistance-associated protein (MRP) mRNA, complete cds.,multidrug resistance protein,multiple drug resistance protein 1,multiple drug resistance-associated protein, Gene Alternate Symbols: ABC29,ABCC,DKFZp686N04233,DKFZp781G125,GS-X,L05628.1,MRP,MRpgkb, v-abl Abelson murine leukemia viral oncogene homolog 1 Gene Symbol: ABL1 Gene Alternate Names: Abelson murine leukemia viral (v-abl) oncogene homolog 1,proto-oncogene tyrosine-protein kinase ABL1, Gene Alternate Symbols: ABL,JTK7,c-ABL,pgkb50,v-abl, acetyl-Coenzyme A carboxylase alpha Gene Symbol: ACACA Gene Alternate Symbols: ACAC,ACC,ACC1,ACCA, acid phosphatase 2, lysosomal Gene Symbol: ACpmid 5,10-methylenetetrahydrofolate reductase (NADPH) Gene Symbol: MTHFR Gene Alternate Names: 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH) - ALTERNATIVELY SPLICED; MTHFR,METHYLENETETRAHYDROFOLATE REDUCTASE LONG ISOFORM, ALTERNATIVELY SPLICED,Methylenetetrahydrofolate reductase,methylenetetrahydrofolate reductase intermediate form, Gene Alternate Symbols: AY046562.1, adenosine deaminase Gene Symbol: ADA Gene Alternate Names: adenosine aminohydrolase, adducin 2 (beta) Gene Symbol: ADD2 Gene Alternate Names: Adducin-2 (beta),beta adducin, Gene Alternate Symbols: ADDB, adducin 3 (gamma) Gene Symbol: ADD3 Gene Alternate Names: adducin-like, Gene Alternate Symbols: ADDL, alcohol dehydrogenase 1A (class I), alpha polypeptide Gene Symbol: ADH1A Gene Alternate Names: ADH, alpha subunit,alcohol dehydrogenase 1,alcohol dehydrogenase 1 (class I), alpha polypeptide,aldehyde reductase, Gene Alternate Symbols: ADH1, alcohol dehydrogenase IB (class I), beta polypeptide Gene Symbol: ADH1B Gene Alternate Names: ADH, beta subunit,alcohol dehydrogenase 1B (class I), beta polypeptide,alcohol dehydrogenase 2,alcohol dehydrogenase 2 (class I), beta polypeptide,aldehyde reductase, Gene Alternate Symbols: ADH2, alcohol dehydrogenase 1C (class I), gamma polypeptide Gene Symbol: ADH1C Gene Alternate Names: ADH, gamma subunit,alcohol dehydrogenase 3,alcohol dehydrogenase 3 (class I), gamma polypeptide,aldehyde reductase, Gene Alternate Symbols: ADH3, alcohol dehydrogenase 4 (class II), pi polypeptide Gene Symbol: ADH4 Gene Alternate Names: aldehyde reductase, Gene Alternate Symbols: ADH-2, alcohol dehydrogenase 5 (class III), chi polypeptide Gene Symbol: ADH5 Gene Alternate Names: Alcohol dehydrogenase (class III), chi polypeptide,clutathione-dependent formaldehyde dehydrogenase,formaldehyde dehydrogenase,glutathione-dependent formaldehyde dehydrogenase, Gene Alternate Symbols: ADH-3,ADHX,FDH, alcohol dehydrogenase 6 (class V) Gene Symbol: ADH6 Gene Alternate Names: aldehyde reductase, Gene Alternate Symbols: ADH-5, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene Symbol: ADH7 Gene Alternate Names: Alcohol dehydrogenase-7,gastric alcohol dehydrogenase, Gene Alternate Symbols: ADH-4, adenosine A1 receptor Gene Symbol: ADORA1 Gene Alternate Symbols: RDC7, adenosine A2a receptor Gene Symbol: ADORA2A Gene Alternate Names: adenosine A2 receptor,adenosine receptor subtype A2a, Gene Alternate Symbols: ADORA2,RDC8,hA2aR, adenosine A2b receptor Gene Symbol: ADORA2B Gene Alternate Symbols: ADORA2, adenosine A3 receptor Gene Symbol: ADORA3 Gene Alternate Symbols: A3AR,AD026,Rpgkb1-552M11.7,bA552M11.5, adrenergic, alpha-1D-, receptor Gene Symbol: ADRA1D Gene Alternate Names: ADRA1,ADRA1A,ADRA1R,adrenergic, alpha -1D-, receptor,adrenergic, alpha-1A-, receptor,adrenergic, alpha-1D-, receptor (NOTE: redefinition of symbol),dJ779E11.2 (adrenergic, alpha-1D-, receptor (alpha 1D-adrenoreceptor)), Gene Alternate Symbols: ADRA1,ADRA1A,ADRA1R,ALPHA1,DAR,dJ779E11.2, S-adenosylhomocysteine hydrolase Gene Symbol: AHCY Gene Alternate Names: adenosylhomocysteinase, Gene Alternate Symbols: SAHH, alpha-2-HS-glycoprotein Gene Symbol: AHSG Gene Alternate Names: Alpha-2HS-glycoprotein, Gene Alternate Symbols: A2HS,AHS,FETUA,HSGA, aldo-keto reductase family 1, member A1 (aldehyde reductase) Gene Symbol: AKR1A1 Gene Alternate Names: alcohol dehydrogenase,aldehyde reductase, Gene Alternate Symbols: ALDR1,ALR,MGC12529,MGC1380, v-akt murine thymoma viral oncogene homolog 1 Gene Symbol: AKT1 Gene Alternate Names: Murine thymoma viral (v-akt) oncogene homolog-1, Gene Alternate Symbols: MGC99656,PKB,PRKBA,RAC,RAC-ALPHA, v-akt murine thymoma viral oncogene homolog 2 Gene Symbol: AKT2 Gene Alternate Names: Murine thymoma viral (v-akt) homolog-2,rac protein kinase beta, Gene Alternate Symbols: PKBBETA,PRKBB,RAC-BETA, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) Gene Symbol: AKT3 Gene Alternate Names: RAC-gamma serine/threonine protein kinase,protein kinase B gamma,serine threonine protein kinase, Akt-3, Gene Alternate Symbols: DKFZP434N0250,PKBG,PRKBG,RAC-GAMMA,RAC-PK-gamma,RAC-gamma,STK-2, aldehyde dehydrogenase 2 family (mitochondrial) Gene Symbol: ALDH2 Gene Alternate Names: ALDH class 2,acetaldehyde dehydrogenase 2,aldehyde dehydrogenase 2, mitochondrial,liver mitochondrial ALDH,nucleus-encoded mitochondrial aldehyde dehydrogenase 2, Gene Alternate Symbols: ALDH-E2,ALDHI,ALDM,MGC1806, Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Gene Symbol: RAPH1 Gene Alternate Names: KIAA1681,amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18,amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9,lamellipodin,proline rich EVH1 ligand 2,putative GTPase regulator, Gene Alternate Symbols: ALS2CR18,ALS2CR9,KIAA1681,LPD,PREL2,RMO1,RalGDS/AF-6, aristaless-like homeobox 4 Gene Symbol: ALX4 Gene Alternate Names: homeodomain transcription factor ALX4,parietal foramina 2, Gene Alternate Symbols: FPP,KIAA1788,PFM,PFM1,PFM2, aminomethyltransferase Gene Symbol: AMT Gene Alternate Names: aminomethyltransferase (glycine cleavage system protein T), Gene Alternate Symbols: GCE,GCST,NKH, aldehyde oxidase 1 Gene Symbol: AOX1 Gene Alternate Symbols: AO,AOH1, adaptor-related protein complex 1, sigma 2 subunit Gene Symbol: ApgkbS2 Gene Alternate Names: Golgi adaptor HA1/Apgkb adaptin sigma 1B subunit,clathrin adaptor complex Apgkb sigma 1B subunit,clathrin assembly protein complex 1 sigma-1B small chain,clathrin-associated/assembly/adaptor protein small 1-like, Gene Alternate Symbols: DC22,MGC:1902,SIGMA1B, adaptor-related protein complex 2, beta 1 subunit Gene Symbol: ApmidB1 Gene Alternate Names: adaptin, beta 2 (beta),clathrin-associated/assembly/adaptor protein, large, beta 1, Gene Alternate Symbols: ADTB2,Apgkb05B,Apmid-BETA,CLAPB1,DKFZp781K0743, adenomatosis polyposis coli Gene Symbol: APC Gene Alternate Symbols: Dpmid,Dpmid.5,DP3,FAP,FPC,GS, apolipoprotein D Gene Symbol: APOD ADP-ribosylation factor 4 Gene Symbol: ARF4 Rho GTPase activating protein 5 Gene Symbol: ARHGAP5 Gene Alternate Names: RhoGAP5,pgkb90-B, Gene Alternate Symbols: pgkb90-B,RHOGAP5,RhoGAP5,pgkb90-B, ADP-ribosylation factor-like 4C Gene Symbol: ARL4C Gene Alternate Names: ADP-ribosylation factor-like 7, Gene Alternate Symbols: ARL7,LAK, aryl hydrocarbon receptor nuclear translocator Gene Symbol: ARNT Gene Alternate Names: dioxin receptor, nuclear translocator,hypoxia-inducible factor 1, beta subunit, Gene Alternate Symbols: HIF-1beta,HIF1B,HIF1BETA,HIF1beta,TANGO, asparagine synthetase Gene Symbol: ASNS Gene Alternate Names: TS11 cell cycle control protein,glutamine-dependent asparagine synthetase, Gene Alternate Symbols: TS11, activating transcription factor 1 Gene Symbol: ATF1 Gene Alternate Symbols: TREB36, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene Symbol: ATIC Gene Alternate Names: AICARFT/IMPCHASE, Gene Alternate Symbols: AICAR,AICARFT,IMPCHASE,PURH, attractin Gene Symbol: ATRN Gene Alternate Names: attractin-2,mahogany protein, Gene Alternate Symbols: DPPT-L,KIAA0548,MGC126754,MGCA, azurocidin 1 (cationic antimicrobial protein 37) Gene Symbol: AZU1 Gene Alternate Names: cationic antimicrobial protein 37,heparin-binding protein,neutrophil azurocidin, Gene Alternate Symbols: AZAMP,AZU,CAP37,HBP,HUMAZUR,NAZC, BCL2-antagonist/killer 1 Gene Symbol: BAK1 Gene Alternate Names: Bcl-2 homologous antagonist/killer,apoptosis regulator BAK,cell death inhibitor 1, Gene Alternate Symbols: BAK,BAK-LIKE,BCL2L7,CDN1,MGC117255,MGC3887, BCL2-associated X protein Gene Symbol: BAX Gene Alternate Names: Bax zeta,apoptosis regulator BAX, butyrylcholinesterase Gene Symbol: BCHE Gene Alternate Symbols: CHE1,E1, B-cell CLL/lymphoma 2 Gene Symbol: BCL2 Gene Alternate Symbols: Bcl-2, brain-derived neurotrophic factor Gene Symbol: BDNF Gene Alternate Symbols: MGC34632, baculoviral IAP repeat-containing 1 Gene Symbol: BIRC1 Gene Alternate Names: neuronal apoptosis inhibitory protein, Gene Alternate Symbols: NAIP,psiNAIP, baculoviral IAP repeat-containing 3 Gene Symbol: BIRC3 Gene Alternate Names: TNFR2-TRAF signalling complex protein,apoptosis inhibitor 2,cIApmid,hiap-1, Gene Alternate Symbols: AIpgkb,API2,CIApmid,HAIpgkb,HIApgkb,MALT2,MIHC,RNF49,cIApmid,hiap-1, B lymphoma Mo-MLV insertion region (mouse) Gene Symbol: BMI1 Gene Alternate Names: Oncogene BMI-1,RNF51,murine leukemia viral (bmi-1) oncogene homolog,oncogene BMI-1,polycomb group ring finger 4, Gene Alternate Symbols: MGC12685,PCGF4,RNF51, bone morphogenetic protein 1 Gene Symbol: BMpgkb Gene Alternate Names: PCP,procollagen C-endopeptidase, Gene Alternate Symbols: FLJ44432,PCOLC,PCP,TLD, nitric oxide synthase 3 (endothelial cell) Gene Symbol: NOS3 Gene Alternate Names: ECNOS,NOS III,endothelial nitric oxidase synthase,endothelial nitric oxide synthase, Gene Alternate Symbols: ECNOS,NOS III,eNOS, breast cancer 1, early onset Gene Symbol: BRCA1 Gene Alternate Names: breast-ovarian cancer, included, Gene Alternate Symbols: BRCAI,BRCC1,IRIS,PSCP,RNF53, breast cancer 2, early onset Gene Symbol: BRCA2 Gene Alternate Names: Fanconi anemia, complementation group D1, Gene Alternate Symbols: BRCC2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1, bombesin-like receptor 3 Gene Symbol: BRS3 bystin-like Gene Symbol: BYSL Gene Alternate Symbols: BYSTIN, neuropeptide Y Gene Symbol: NPY Gene Alternate Symbols: PYY4, natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) Gene Symbol: NPR2 Gene Alternate Names: GUC2B,Natriuretic peptide receptor B/guanylate cyclase B,OTTHUMP00000045390,natriuretic peptide receptor B\/guanylate cyclase B (atrionatriuretic peptide receptor B), Gene Alternate Symbols: AMDM,ANPRB,GUC2B,GUCY2B,NPRB,NPRBi, tribbles homolog 3 (Drosophila) Gene Symbol: TRIB3 Gene Alternate Names: TRB3,chromosome 20 open reading frame 97,dJ1103G7.3,neuronal cell death inducible putative kinase,p65-interacting inhibitor of NF-kappaB,protein kinase domains containing protein similar to phosphoprotein C8FW,tribbles3, Gene Alternate Symbols: C20orf97,NIPK,SINK,SKIP3,TRB3,dJ1103G7.3, carbonic anhydrase III, muscle specific Gene Symbol: CA3 Gene Alternate Names: Carbonic anhydrase III, Gene Alternate Symbols: CAIII,Car3, adenylate cyclase 3 Gene Symbol: ADCY3 Gene Alternate Names: ATP pyrophosphate-lyase,adenylyl cyclase, type III, Gene Alternate Symbols: AC3,KIAA0511, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Gene Symbol: CACNA1A Gene Alternate Names: brain calcium channel 1,calcium channel, L type, alpha-1 polypeptide, isoform 4, Gene Alternate Symbols: APCA,CACNL1A4,CAV2.1,EA2,FHM,HPCA,MHP,MHpgkb,SCA6, calcium channel, voltage-dependent, L type, alpha 1B subunit Gene Symbol: CACNA1B Gene Alternate Names: calcium channel, N type,calcium channel, voltage-dependent, alpha 1B subunit, N type, Gene Alternate Symbols: BIII,CACNL1A5,CACNN, calcium channel, voltage-dependent, alpha 1E subunit Gene Symbol: CACNA1E Gene Alternate Symbols: BII,CACH6,CACNL1A6,Cav2.3, cathelicidin antimicrobial peptide Gene Symbol: CAMP Gene Alternate Symbols: CApgkb8,FALL-39,FALL39,HSD26,LL37, calpain 10 Gene Symbol: CAPN10 Gene Alternate Names: calcium-activated neutral protease, cystathionine-beta-synthase Gene Symbol: CBS Gene Alternate Names: beta-thionase,human cystathionine-beta-synthase,methylcysteine synthase,serine sulfhydrase, Gene Alternate Symbols: HIP4, cyclin A1 Gene Symbol: CCNA1 CD1b molecule Gene Symbol: CD1B Gene Alternate Names: CD1B antigen, b polypeptide,CD1b antigen,Thymocyte antigen CD1B,a1 domain, Gene Alternate Symbols: CD1,CD1A,CD1b,MGC125990,MGC125991,R1, CDC20 cell division cycle 20 homolog (S. cerevisiae) Gene Symbol: CDC20 Gene Alternate Names: CDC20 (cell division cycle 20, S. cerevisiae, homolog),cell division cycle 20, S.cerevisiae homolog, Gene Alternate Symbols: CDC20A,MGC102824,bA276H19.3,p55CDC, cyclin-dependent kinase-like 1 (CDC2-related kinase) Gene Symbol: CDKL1 Gene Alternate Names: CDC2-related kinase 1,p42,serine/threonine protein kinase KKIALRE, Gene Alternate Symbols: KKIALRE,p42, cyclin-dependent kinase inhibitor 2B (pgkb5, inhibits CDK4) Gene Symbol: CDKN2B Gene Alternate Names: CDK inhibitory protein,CDK4B inhibitor,cyclin-dependent kinase 4 inhibitor B,cyclin-dependent kinases 4 and 6 binding protein,multiple tumor suppressor 2,pgkb4_CDK inhibitor,pgkb4_INK4B,pgkb5 CDK inhibitor,pgkb5_INK4B, Gene Alternate Symbols: INK4B,MTS2,pgkb5,Tpgkb5, phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) Gene Symbol: PDE4C Gene Alternate Names: Phosphodiesterase-4C, cAMP-specific (dunce (Drosophila)-homolog,phosphodiesterase 4C, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E1), Gene Alternate Symbols: DPDE1,MGC126222,PDE4C-791, chorionic gonadotropin, beta polypeptide Gene Symbol: CGB Gene Alternate Names: chorionic gonadotropin beta chain, Gene Alternate Symbols: CGB3,hCGB, regulator of chromosome condensation 1 Gene Symbol: RCC1 Gene Alternate Names: chromosome condensation 1,regulator of chromosome condensation, Gene Alternate Symbols: CHC1,RCC1-I, cholinergic receptor, nicotinic, alpha 2 (neuronal) Gene Symbol: CHRNA2 Gene Alternate Names: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal), cholinergic receptor, nicotinic, alpha 4 Gene Symbol: CHRNA4 Gene Alternate Names: cholinergic receptor, nicotinic, alpha polypeptide 4,neuronal nicotinic acetylcholine receptor alpha-4 subunit, Gene Alternate Symbols: BFNC,EBN,EBN1,ENFL1,NACRA4, cholinergic receptor, nicotinic, beta 4 Gene Symbol: CHRNB4 Gene Alternate Names: Cholinergic receptor, neuronal nicotinic, beta polypeptide-4,cholinergic receptor, nicotinic, beta polypeptide 4, CDC28 protein kinase regulatory subunit 2 Gene Symbol: CKS2 Gene Alternate Names: CDC28 protein kinase 2,CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2, Gene Alternate Symbols: CKSHS2, CDC-like kinase 1 Gene Symbol: CLK1 Gene Alternate Names: protein tyrosine kinase STY, Gene Alternate Symbols: CLK,CLK/STY,STY, clock homolog (mouse) Gene Symbol: CLOCK Gene Alternate Names: circadian locomoter output cycles kaput protein,clock (mouse) homolog, Gene Alternate Symbols: KIAA0334,hCLOCK, CCR4-NOT transcription complex, subunit 8 Gene Symbol: CNOT8 Gene Alternate Names: PGK promoter directed over production,POpmid (yeast homolog), Gene Alternate Symbols: CAF1,CALIF,HCAF1,POpmid,hCAF1, ATP-binding cassette, sub-family B (MDR/TAP), member 1 Gene Symbol: ABCB1 Gene Alternate Names: ABC20,ATP-BINDING CASSETTE, SUBFAMILY B, MEMBER 1; ABCB1,CD243,DOXORUBICIN RESISTANCE,Gpgkb70,Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), mRNA.,P glycoprotein 1,P glycoprotein 1/multiple drug resistance 1,P-GLYCOPROTEIN 1; PGY1,P-glycoprotein 1,P-glycoprotein-1/multiple drug resistance-1,P-gp,colchicin sensitivity,doxorubicin resistance,multidrug resistance 1, Gene Alternate Symbols: ABC20,CD243,CLCS,Gpgkb70,MDR1,NM_000927.1,P-GP,P-gp,PGY1, ceruloplasmin (ferroxidase) Gene Symbol: CP Gene Alternate Names: Ceruloplasmin, Gene Alternate Symbols: CP-2, cAMP responsive element binding protein 1 Gene Symbol: CREB1 Gene Alternate Names: active transcription factor CREB,cAMP-response element-binding protein-1,transactivator protein, Gene Alternate Symbols: CREB,MGC9284, cAMP responsive element modulator Gene Symbol: CREM Gene Alternate Names: cAMP-responsive element modulator,inducible cAMP early repressor ICER, Gene Alternate Symbols: ICER,MGC111110,MGC17881,MGC41893,hCREM-2, corticotropin releasing hormone receptor 1 Gene Symbol: CRHR1 Gene Alternate Names: CRF-R,CRF1,corticotropin releasing hormone receptor,seven transmembrane helix receptor, Gene Alternate Symbols: CRF-R,CRF1,CRFR1,CRH-R1h,CRHR,CRHR1f, corticotropin releasing hormone receptor 2 Gene Symbol: CRHR2 Gene Alternate Symbols: CRFR2, v-crk sarcoma virus CT10 oncogene homolog (avian) Gene Symbol: CRK Gene Alternate Names: avian sarcoma virus CT10 (v-crk) oncogene homolog,v-crk avian sarcoma virus CT10 oncogene homolog, Gene Alternate Symbols: CRKII, crystallin, zeta (quinone reductase) Gene Symbol: CRYZ Gene Alternate Names: NADPH:quinone reductase, Gene Alternate Symbols: DKFZp779E0834,FLJ41475, colony stimulating factor 3 receptor (granulocyte) Gene Symbol: CSF3R Gene Alternate Names: CD114 antigen,Colony-stimulating factor-3 receptor (granulocyte),GCSFR,granulocyte colony stimulating factor receptor, Gene Alternate Symbols: CD114,GCSFR, chorionic somatomammotropin hormone 2 Gene Symbol: CSH2 Gene Alternate Names: CS-2,chorionic somatomammotropin B,hCS-B,placental lactogen, Gene Alternate Symbols: CS-2,CSB,hCS-B, c-src tyrosine kinase Gene Symbol: CSK Gene Alternate Symbols: MGC117393, cystatin F (leukocystatin) Gene Symbol: CST7 Gene Alternate Names: cystatin 7,cystatin F,cystatin-like metastasis-associated protein,leukocystatin, Gene Alternate Symbols: CMAP, cathepsin G Gene Symbol: CTSG Gene Alternate Symbols: CG,MGC23078, cathepsin L Gene Symbol: CTSL Gene Alternate Names: major excreted protein, Gene Alternate Symbols: CATL,MEP, cullin 4B Gene Symbol: CUL4B Gene Alternate Names: Cullin-4B, Gene Alternate Symbols: KIAA0695, cytochrome P450, family 1, subfamily A, polypeptide 1 Gene Symbol: CYpgkbA1 Gene Alternate Names: P450 form 6,aryl hydrocarbon hydroxylase,cytochrome pgkb-450, dioxin-inducible,cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1,flavoprotein-linked monooxygenase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: AHH,AHRR,Cpgkb1,CYpgkb,pgkb-450,P450-C,P450DX, cytochrome P450, family 1, subfamily A, polypeptide 2 Gene Symbol: CYpgkbA2 Gene Alternate Names: P450 form 4,aryl hydrocarbon hydroxylase,cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2,dioxin-inducible P3-450,flavoprotein-linked monooxygenase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: Cpgkb2,P3-450,P450(PA), cytochrome P450, family 1, subfamily B, polypeptide 1 Gene Symbol: CYpgkbB1 Gene Alternate Names: CpgkbB,aryl hydrocarbon hydroxylase,cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile),flavoprotein-linked monooxygenase,microsomal monooxygenase,xenobiotic monooxygenase, Gene Alternate Symbols: CpgkbB,GLC3A, cytochrome P450, family 2, subfamily A, polypeptide 7 Gene Symbol: CYpmidA7 Gene Alternate Names: cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7, Gene Alternate Symbols: CPA7,CPAD,CYpmidA,CYPIIA7,P450-IIA4, cytochrome P450, family 3, subfamily A Gene Symbol: CYP3A Gene Alternate Names: cytochrome P450, subfamily IIIA (niphedipine oxidase), Gene Alternate Symbols: CYP3, DNA-damage-inducible transcript 3 Gene Symbol: DDIT3 Gene Alternate Names: C/EBP homologous protein,C/EBP zeta,growth arrest- and DNA damage-inducible, Gene Alternate Symbols: CEBPZ,CHOP,CHOpgkb0,GADD153,MGC4154, defensin, alpha 3, neutrophil-specific Gene Symbol: DEFA3 Gene Alternate Names: defensin 3, neutrophil-specific,human neutrophil peptide 3, Gene Alternate Symbols: DEF3,HNP-3,HNP3,HP-3, defensin, alpha 4, corticostatin Gene Symbol: DEFA4 Gene Alternate Names: corticostatin,corticostatin HP4 precursor, Gene Alternate Symbols: DEF4,HNP-4,HP-4,HP4,MGC120099,MGC138296, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) Gene Symbol: DFFB Gene Alternate Names: CPAN,DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase),DNA fragmentation factor, 40 kD, beta subunit,caspase-activated DNase, Gene Alternate Symbols: CAD,CPAN,DFF-40,DFF2,DFF40, deoxyhypusine synthase Gene Symbol: DHPS Gene Alternate Symbols: MIG13, dyskeratosis congenita 1, dyskerin Gene Symbol: DKC1 Gene Alternate Names: Dyskerin, Gene Alternate Symbols: DKC,NAP57,NOLA4,XApgkb01,dyskerin, phenylethanolamine N-methyltransferase Gene Symbol: PNMT Gene Alternate Symbols: PENT, DNA (cytosine-5-)-methyltransferase 1 Gene Symbol: DNMT1 Gene Alternate Names: DNA methyltransferase,DNA methyltransferase 1, Gene Alternate Symbols: CXXC9,DNMT,FLJ16293,MCMT,MGC104992, dihydropyrimidinase-like 2 Gene Symbol: DPYSL2 Gene Alternate Names: collapsin response mediator protein hCRMP-2, Gene Alternate Symbols: CRMpmid,DHPRpmid,DRP-2,DRpmid, dopamine receptor D3 Gene Symbol: DRD3 Gene Alternate Symbols: D3DR,ETM1,FET1, desmoglein 1 Gene Symbol: DSG1 Gene Alternate Names: desmosomal glycoprotein 1, Gene Alternate Symbols: CDHF4,DG1,DSG, early B-cell factor Gene Symbol: EBF Gene Alternate Names: Collier, Olf and EBF,Collier, Olf and EBF transcription factor 1,Early B-cell factor (olfactory neuronal transcription factor 1),early B-cell factor 1,olfactory neuronal transcription factor 1, Gene Alternate Symbols: COE1,EBF1,O/E-1,OLF1, ephrin-B2 Gene Symbol: EFNB2 Gene Alternate Names: HTK ligand,Htk-L,eph-related receptor tyrosine kinase ligand 5,eph-related receptor tyrosine kinase ligand 5 (ephrin-B2), Gene Alternate Symbols: EPLG5,HTKL,Htk-L,LERK5,MGC126226,MGC126227,MGC126228, polymerase (DNA directed), epsilon Gene Symbol: POLE Gene Alternate Symbols: DKFZp434F222,FLJ21434,POLE1, eukaryotic translation initiation factor 4A, isoform 1 Gene Symbol: EIF4A1 Gene Alternate Symbols: DDX2A,EIF-4A,EIF4A, elastase 2, neutrophil Gene Symbol: ELA2 Gene Alternate Symbols: HLE,HNE,NE,PMN-E, ectonucleotide pyrophosphatase/phosphodiesterase 1 Gene Symbol: ENPpgkb Gene Alternate Names: phosphodiesterase I/nucleotide pyrophosphatase 1 (homologous to mouse Ly-41 antigen),plasma-cell membrane glycoprotein, Gene Alternate Symbols: M6S1,NPpgkb,NPPS,PC-1,PCA1,PDNpgkb, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Gene Symbol: ERBB2 Gene Alternate Names: Avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 2,c-erb B2,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), Gene Alternate Symbols: HER-2,HER-2/neu,HER2,NEU,NGL,TKR1, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Gene Symbol: ERBB3 Gene Alternate Names: Transformation gene ERBB-3,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3, Gene Alternate Symbols: ErbB-3,HER3,MDA-BF-1,MGC88033,c-erbB-3,c-erbB3,erbB3-S,pgkb80-ErbB3,p45-sErbB3,p85-sErbB3, excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) Gene Symbol: ERCC2 Gene Alternate Names: EM9,MAG,complementing,cross,deficiency,excision,excision repair cross complementing rodent repair deficiency,,malignancy-associated protein, Gene Alternate Symbols: EM9,MAG,MGC102762,MGC126218,MGC126219,TTD,XPD, excision repair cross-complementing rodent repair deficiency, complementation group 4 Gene Symbol: ERCC4 Gene Alternate Names: Excision-repair,Excision-repair, complementing defective, in Chinese hamster,,excision-repair, complementing defective, in Chinese hamster,xeroderma pigmentosum, complementation group F, Gene Alternate Symbols: RAD1,XPF, estrogen receptor 2 (ER beta) Gene Symbol: ESR2 Gene Alternate Names: Erb,NR3A2, Gene Alternate Symbols: 5pgkb52,ER-BETA,ESR-BETA,ESRB,ESTRB,Erb,NR3A2, ets variant gene 5 (ets-related molecule) Gene Symbol: ETV5 Gene Alternate Symbols: ERM, ets variant gene 6 (TEL oncogene) Gene Symbol: ETV6 Gene Alternate Names: TEL1 oncogene, Gene Alternate Symbols: TEL, exostoses (multiple) 2 Gene Symbol: EXT2 Gene Alternate Symbols: SOTV, peroxisome proliferative activated receptor, alpha Gene Symbol: PPARA Gene Alternate Names: NR1C1,OTTHUMP00000028713,OTTHUMP00000042872,hPPAR, Gene Alternate Symbols: HPPAR,MGC2237,MGC2452,NR1C1,PPAR,hPPAR, Fc fragment of IgG, low affinity IIa, receptor (CD32) Gene Symbol: FCGR2A Gene Alternate Names: Fc fragment of IgG, low affinity IIa, receptor for (CD32), Gene Alternate Symbols: CD32,CD32A,CDw32,FCG2,FCGR2,FCGR2A1,FcGR,IGFR2,MGC23887,MGC30032, peroxisome proliferative activated receptor, gamma Gene Symbol: PPARG Gene Alternate Names: NR1C3,PPAR gamma,PPARG1,PPARG2,peroxisome proliferator activated-receptor gamma,peroxisome proliferator-activated receptor gamma 1,ppar gamma2, Gene Alternate Symbols: HUMPPARG,NR1C3,PPARG1,PPARG2, fidlblast growth factor 2 (basic) Gene Symbol: FGF2 Gene Alternate Names: heparin-binding growth factor 2 precusor,prostatropin, Gene Alternate Symbols: BFGF,FGFB,HBGH-2, fidlblast growth factor 9 (glia-activating factor) Gene Symbol: FGF9 Gene Alternate Names: glia-activating factor, Gene Alternate Symbols: GAF,HBFG-9,MGC119914,MGC119915, fidlblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) Gene Symbol: FGFR1 Gene Alternate Names: FLG protein,FMS-like tyrosine kinase 2,Kallmann syndrome 2 (autosomal dominant),N-sam tyrosine kinase,basic fidlblast growth factor receptor 1,fms-related tyrosine kinase-2,heparin-binding growth factor receptor,hydroxyaryl-protein kinase,protein-tyrosine kinase,tyrosylprotein kinase, Gene Alternate Symbols: BFGFR,C-FGR,CD331,CEK,FGFBR,FLG,FLJ14326,FLT2,H2,H3,H4,H5,HBGFR,KAL2,N-SAM, fidlblast growth factor receptor 4 Gene Symbol: FGFR4 Gene Alternate Names: hydroxyaryl-protein kinase,protein-tyrosine kinase,tyrosine kinase related to fidlblast growth factor receptor,tyrosylprotein kinase, Gene Alternate Symbols: CD334,JTK2,MGC20292,TKF, filamin A, alpha (actin binding protein 280) Gene Symbol: FLNA Gene Alternate Names: actin-binding protein-280,filamin 1,filamin A,filamin A, alpha (actin-binding protein-280),otopalatodigital syndrome 1,otopalatodigital syndrome 2, Gene Alternate Symbols: ABP-280,ABPX,DKFZp434P031,FLN,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Gene Symbol: FLT1 Gene Alternate Symbols: FLT,VEGFR1, mitogen-activated protein kinase 8 Gene Symbol: MAPK8 Gene Alternate Names: JNK,JNK1,JNK1 alpha protein kinase,JNK1 beta protein kinase,SAPK1,c-Jun N-terminal kinase 1,protein kinase JNK1,stress-activated protein kinase JNK1, Gene Alternate Symbols: JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1, frequenin homolog (Drosophila) Gene Symbol: FREQ Gene Alternate Names: frequenin (Drosophila) homolog,neuronal calcium sensor 1, Gene Alternate Symbols: DKFZp761L1223,FLUP,NCS-1,NCS1, fyn-related kinase Gene Symbol: FRK Gene Alternate Names: PTK5 protein tyrosine kinase 5,nuclear tyrosine protein kinase RAK,tyrosine-protein kinase FRK, Gene Alternate Symbols: GTK,PTK5,RAK, ferritin, heavy polypeptide 1 Gene Symbol: FTH1 Gene Alternate Symbols: FTH,FTHL6,MGC104426,PIG15,PLIF, aldehyde dehydrogenase 1 family, member L1 Gene Symbol: ALDH1L1 Gene Alternate Names: formyltetrahydrofolate dehydrogenase, Gene Alternate Symbols: DKFZp781N0997,FTHFD, mitogen-activated protein kinase kinase 7 Gene Symbol: MApmidK7 Gene Alternate Names: JNK kinase 2,JNK-activating kinase 2,Jnkk2,MAP kinase kinase 7,MKK7,c-Jun N-terminal kinase kinase 2,dual specificity mitogen-activated protein kinase kinase 7,protein kinase, mitogen-activated, kinase 7 (MAP kinase kinase 7), Gene Alternate Symbols: JNKK2,Jnkk2,MAPKK7,MKK7,PRKMK7, frizzled homolog 2 (Drosophila) Gene Symbol: FZD2 Gene Alternate Names: frizzled (Drosophila) homolog 2, frizzled homolog 6 (Drosophila) Gene Symbol: FZD6 Gene Alternate Names: Frizzled, drosophila, homolog of, 6,frizzled (Drosophila) homolog 6, Gene Alternate Symbols: HFZ6,Hfz6, glucose-6-phosphate dehydrogenase Gene Symbol: G6PD Gene Alternate Symbols: G6PD1, GRB2-associated binding protein 1 Gene Symbol: GAB1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) Gene Symbol: GALNT7 Gene Alternate Names: UDP-N-acetyl-alpha-D-galactosamine, Gene Alternate Symbols: GALNAC-T7,GalNAcT7, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Gene Symbol: GART Gene Alternate Names: phosphoribosylglycinamide formyltransferase,trifunctional purine biosynthetic protein adenosine-3, Gene Alternate Symbols: AIRS,GARS,GARTF,MGC47764,PAIS,PGFT,PRGS, glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen dl:Disease, glycogen storage dl:Disease type IV) Gene Symbol: GBE1 Gene Alternate Names: Glycogen branching enzyme, Gene Alternate Symbols: GBE, golgi-specific brefeldin A resistance factor 1 Gene Symbol: GBF1 Gene Alternate Names: golgi-specific Brefeldin A-resistance factor,golgi-specific brefeldin A-resistance factor 1, Gene Alternate Symbols: FLJ21263,FLJ21500,KIAA0248,MGC134877,MGC134878, GTP cyclohydrolase 1 (dopa-responsive dystonia) Gene Symbol: GCH1 Gene Alternate Names: GTP cyclohydrolase 1,GTP cyclohydrolase I, Gene Alternate Symbols: DYT5,GCH,GTP-CH-1,GTPCH1, GTP cyclohydrolase I feedback regulator Gene Symbol: GCHFR Gene Alternate Names: GTP cyclohydrolase I feedback regulatory protein, Gene Alternate Symbols: GFRP,HsT16933,MGC138467,MGC138469,P35, growth differentiation factor 10 Gene Symbol: GDF10 Gene Alternate Names: bone morphogenetic protein 3B, Gene Alternate Symbols: BMP-3b,BMP3B, growth differentiation factor 11 Gene Symbol: GDF11 Gene Alternate Names: bone morphogenetic protein 11, Gene Alternate Symbols: BMP-11,BMpgkb1, gastric inhibitory polypeptide Gene Symbol: GIP gap junction protein, alpha 1, 43kDa (connexin 43) Gene Symbol: GJA1 Gene Alternate Names: (connexin,43),gap junction protein, alpha 1, 43kD,gap junction protein, alpha 1, 43kD (connexin 43),gap junction protein, alpha-like,oculodentodigital dysplasia (syndactyly type III), Gene Alternate Symbols: CX43,DFNB38,GJAL,ODD,ODDD,ODOD,SDTY3, guanine nucleotide binding protein (G protein), gamma 10 Gene Symbol: GNG10 Gene Alternate Names: guanine nucleotide binding protein 10, golgi autoantigen, golgin subfamily a, 2 Gene Symbol: GOLGA2 Gene Alternate Names: Golgi matrix protein GM130,SY11 protein,golgin-95, Gene Alternate Symbols: GM130,MGC20672,golgin-95, glutathione peroxidase 1 Gene Symbol: GPX1 Gene Alternate Symbols: GSHPX1,MGC14399,MGC88245, glutathione synthetase Gene Symbol: GSS Gene Alternate Names: GSH synthetase,glutathione synthase, Gene Alternate Symbols: GSHS,MGC14098, glutathione S-transferase A1 Gene Symbol: GSTA1 Gene Alternate Names: GST, class alpha, 1,GST-epsilon,H-A,S-(hydroxyalkyl)glutathione lyase A1,glutathione S-alkyltransferase A1,glutathione S-aralkyltransferase A1,glutathione S-aryltransferase A1,glutathione S-transferase 2, Gene Alternate Symbols: GST2,GSTA1-1,GTH1,MGC131939, glutathione S-transferase pi Gene Symbol: GSTpgkb Gene Alternate Names: deafness, X-linked 7,fatty acid ethyl ester synthase III, Gene Alternate Symbols: DFN7,FAEES3,GST3,PI, glycogen synthase 2 (liver) Gene Symbol: GYS2 granzyme M (lymphocyte met-ase 1) Gene Symbol: GZMM Gene Alternate Names: lymphocyte met-ase 1, Gene Alternate Symbols: LMET1,MET1, H3 histone, family 3B (H3.3B) Gene Symbol: H3F3B Gene Alternate Symbols: H3.3B,H3F3A, histone acetyltransferase 1 Gene Symbol: HAT1 homeobox, hematopoietically expressed Gene Symbol: HHEX Gene Alternate Names: hematopoietically expressed homeobox,proline-rich homeodomain-containing transcription factor, Gene Alternate Symbols: HEX,HMPH,HOX11L-PEN,PRH,PRHX, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Gene Symbol: HIF1A Gene Alternate Names: ARNT interacting protein,member of PAS superfamily 1, Gene Alternate Symbols: HIF-1ALPHA,HIF-1alpha,HIF1-ALPHA,MOpgkb,PASD8, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Gene Symbol: PTGS2 Gene Alternate Names: prostaglandin G/H synthase and cyclooxygenase, Gene Alternate Symbols: COX-2,COX2,PGG/HS,PGHS-2,PHS-2,hCox-2, prefoldin subunit 6 Gene Symbol: PFDN6 Gene Alternate Names: HLA class II region expressed gene KE2,KE2 protein,prefoldin 6, Gene Alternate Symbols: H2-KE2,HKE2,KE-2,MGC70744,PFD6, retinoblastoma 1 (including osteosarcoma) Gene Symbol: RB1 Gene Alternate Names: Retinoblastoma-1,retinoblastoma susceptibility protein,retinoblastoma suspectibility protein,retinoblastoma-1, Gene Alternate Symbols: OSRC,RB, heat shock 70kDa protein 8 Gene Symbol: HSPA8 Gene Alternate Names: LPS-associated protein 1,constitutive heat shock protein 70,heat shock 70kD protein 8,heat shock 70kD protein 8 (HSP73),heat shock 70kd protein 10,heat shock 70kd protein 10 (HSC71),heat shock cognate protein 54,heat shock cognate protein, 71-kDa,lipopolysaccharide-associated protein 1, Gene Alternate Symbols: HSC54,HSC70,HSC71,HSP71,HSP73,HSPA10,LApgkb,MGC131511,MGC29929,NIP71, 5-hydroxytryptamine (serotonin) receptor 6 Gene Symbol: HTR6 Gene Alternate Symbols: 5-HT6, islet amyloid polypeptide Gene Symbol: IAPP Gene Alternate Names: Islet amyloid polypeptide (diabetes-associated peptide,amylin,amylin), Gene Alternate Symbols: AMYLIN,DAP,IAP, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor Gene Symbol: ICAM1 Gene Alternate Names: CD54,Intercellular adhesion molecule-1,cell surface glycoprotein P3.58, Gene Alternate Symbols: BB2,CD54,P3.58, intercellular adhesion molecule 3 Gene Symbol: ICAM3 Gene Alternate Symbols: CD50,CDW50,ICAM-R, insulin-degrading enzyme Gene Symbol: IDE Gene Alternate Names: insulinase, Gene Alternate Symbols: FLJ35968,INSULYSIN, renin Gene Symbol: REN Gene Alternate Names: angiotensin-forming enzyme precursor,angiotensinogenase precursor,renin precursor, renal, Gene Alternate Symbols: FLJ10761, interleukin 10 Gene Symbol: IL10 Gene Alternate Names: cytokine synthesis inhibitory factor, Gene Alternate Symbols: CSIF,IL-10,IL10A,MGC126450,MGC126451,TGIF, interleukin 1, alpha Gene Symbol: IL1A Gene Alternate Names: hematopoietin-1,preinterleukin 1 alpha, Gene Alternate Symbols: IL-1A,IL1,IL1-ALPHA,IL1F1, interleukin 1, beta Gene Symbol: IL1B Gene Alternate Names: catabolin,interleukin 1,preinterleukin 1 beta, Gene Alternate Symbols: IL-1,IL-1B,IL1-BETA,IL1F2, interleukin 1 receptor, type I Gene Symbol: IL1R1 Gene Alternate Names: antigen CD121a,interleukin 1 receptor alpha, type I,interleukin receptor 1, Gene Alternate Symbols: CD121A,D2S1473,IL-1R-alpha,IL1R,IL1RA,P80, interleukin 1 receptor-like 1 Gene Symbol: IL1RL1 Gene Alternate Names: ST2 protein,ST2V protein,homolog of mouse growth stimulation-expressed gene,interleukin 1 receptor 1,interleukin 1 receptor-related protein, Gene Alternate Symbols: DER4,FIT-1,MGC32623,ST2,ST2L,ST2V,T1, interleukin 1 receptor antagonist Gene Symbol: IL1RN Gene Alternate Names: intracellular IL-1 receptor antagonist type II, Gene Alternate Symbols: ICIL-1RA,IL-1ra3,IL1F3,IL1RA,IRAP,MGC10430, interleukin 3 (colony-stimulating factor, multiple) Gene Symbol: IL3 Gene Alternate Names: Interleukin-3,P-cell stimulating factor,hematopoietic growth factor,mast-cell growth factor,multilineage-colony-stimulating factor, Gene Alternate Symbols: IL-3,MCGF,MGC79398,MGC79399,MULTI-CSF, interleukin 5 (colony-stimulating factor, eosinophil) Gene Symbol: IL5 Gene Alternate Names: B cell differentiation factor I,Interleukin-5,T-cell replacing factor,eosinophil differentiation factor,interleukin-5, Gene Alternate Symbols: EDF,IL-5,TRF, IMP (inosine monophosphate) dehydrogenase 2 Gene Symbol: IMPDH2 Gene Alternate Names: IMP (inosine 5'-phosphate) dehydrogenase-2, Gene Alternate Symbols: IMPD2,IMPDH-II, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Gene Symbol: ITGA2B Gene Alternate Names: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B),platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK, Gene Alternate Symbols: CD41,CD41B,GpmidB,GPIIb,GTA,HPA3, integrin, alpha L (antigen CD11A (pgkb80), lymphocyte function-associated antigen 1; alpha polypeptide) Gene Symbol: ITGAL Gene Alternate Names: antigen CD11A (pgkb80), lymphocyte function-associated antigen 1, alpha polypeptide, Gene Alternate Symbols: CD11A,CD11a,LFA-1,LFA1A, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) Gene Symbol: ITGAV Gene Alternate Names: Integrin, alpha-V (vitronectin receptor, alpha polypeptide),antigen identified by monoclonal antibody L230, Gene Alternate Symbols: CD51,MSK8,VNRA, integrin, beta 5 Gene Symbol: ITGB5 Gene Alternate Symbols: FLJ26658, inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Gene Symbol: ITPA Gene Alternate Names: HLC14-06-P,Inosine triphosphatase-A,My049 protein,dJ794I6.3,inosine triphosphatase-A,inosine triphosphate pyrophosphohydrolase,nucleoside triphosphate diphosphatase,putative oncogene protein HLC14-06-P, Gene Alternate Symbols: C20orf37,HLC14-06-P,ITPase,dJ794I6.3, inositol 1,4,5-triphosphate receptor, type 1 Gene Symbol: ITPR1 Gene Alternate Symbols: INSP3R1,IP3R,IP3R1,Insp3r1, jagged 1 (Alagille syndrome) Gene Symbol: JAG1 Gene Alternate Names: jagged 1,jagged1 (Alagille syndrome), Gene Alternate Symbols: AGS,AHD,AWS,CD339,HJ1,JAGL1,MGC104644, jerky homolog-like (mouse) Gene Symbol: JRKL Gene Alternate Names: Jerky, mouse, homolog-like,erky (mouse) homolog-like,jerky (mouse) homolog-like, Gene Alternate Symbols: HHMJG,MGC129608, v-jun sarcoma virus 17 oncogene homolog (avian) Gene Symbol: JUN Gene Alternate Names: Jun activation domain binding protein,activator protein 1,enhancer-binding protein Apgkb,v-jun avian sarcoma virus 17 oncogene homolog, Gene Alternate Symbols: Apgkb, katanin p80 (WD repeat containing) subunit B 1 Gene Symbol: KATNB1 Gene Alternate Names: katanin (80 kDa),katanin p80 (WD40-containing) subunit B 1, Gene Alternate Symbols: KAT, kinase insert domain receptor (a type III receptor tyrosine kinase) Gene Symbol: KDR Gene Alternate Names: Kinase insert domain receptor, Gene Alternate Symbols: CD309,FLK1,VEGFR,VEGFR2, kinesin family member 3A Gene Symbol: KIF3A Gene Alternate Names: kinesin family protein 3A, kinesin family member 11 Gene Symbol: KIF11 Gene Alternate Names: Eg5,kinesin-like 1,thyroid receptor interacting protein 5, Gene Alternate Symbols: EG5,Eg5,HKSP,KNSL1,TRIP5, keratin 13 Gene Symbol: KRT13 Gene Alternate Names: Keratin-13,cytokeratin 13,keratin, type I cytoskeletal 13, Gene Alternate Symbols: CK13,K13,MGC3781, keratin 83 Gene Symbol: KRT83 Gene Alternate Names: hHb3,hard keratin type II,hard keratin, type II, 3,keratin, hair, basic, 3, Gene Alternate Symbols: HB3,Hb-3,KRTHB3,hard keratin type II, lipocalin 2 (oncogene 24p3) Gene Symbol: LCN2 Gene Alternate Symbols: NGAL, lymphoid enhancer-binding factor 1 Gene Symbol: LEF1 Gene Alternate Names: lymphoid enhancer binding factor-1, Gene Alternate Symbols: DKFZp586H0919,TCF1ALPHA, low density lipoprotein receptor-related protein 6 Gene Symbol: LRP6 Gene Alternate Names: low density lipoprotein-related protein 6, Gene Alternate Symbols: FLJ90062,FLJ90421, lymphotoxin alpha (TNF superfamily, member 1) Gene Symbol: LTA Gene Alternate Names: TNF superfamily, member 1,lymphotoxin A,lyphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor beta,tumor necrosis factor, beta, Gene Alternate Symbols: LT,TNFB,TNFSF1, mitogen-activated protein kinase kinase 1 Gene Symbol: MApmidK1 Gene Alternate Names: protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1), Gene Alternate Symbols: MAPKK1,MEK1,MKK1,PRKMK1, mitogen-activated protein kinase kinase 2 Gene Symbol: MApmidK2 Gene Alternate Names: ERK activator kinase 2,MAP kinase kinase 2,MAPK/ERK kinase 2,dual specificity mitogen-activated protein kinase kinase 2,mitogen-activated protein kinase kinase 2, p45, Gene Alternate Symbols: MAPKK2,MEK2,MKK2,PRKMK2, mitogen-activated protein kinase kinase 3 Gene Symbol: MApmidK3 Gene Alternate Names: MAP kinase kinase 3,MAPK/ERK kinase 3,dual specificity mitogen activated protein kinase kinase 3, Gene Alternate Symbols: MAPKK3,MEK3,MKK3,PRKMK3, mitogen-activated protein kinase kinase 4 Gene Symbol: MApmidK4 Gene Alternate Names: JNK activating kinase 1,JNK-activated kinase 1,MAP kinase kinase 4,MAPK/ERK kinase 4,SAPK/ERK kinase 1,c-Jun N-terminal kinase kinase 1,dual specificity mitogen-activated protein kinase kinase 4, Gene Alternate Symbols: JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1, mitogen-activated protein kinase kinase 5 Gene Symbol: MApmidK5 Gene Alternate Names: MAP kinase kinase MEK5b,MAPK/ERK kinase 5,dual specificity mitogen-activated protein kinase kinase 5, Gene Alternate Symbols: HsT17454,MAPKK5,MEK5,PRKMK5, mitogen-activated protein kinase kinase 6 Gene Symbol: MApmidK6 Gene Alternate Names: protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6), Gene Alternate Symbols: MAPKK6,MEK6,MKK6,PRKMK6,SAPKK3, mitogen-activated protein kinase 1 Gene Symbol: MAPK1 Gene Alternate Names: extracellular signal-regulated kinase 2,mitogen-activated protein kinase 2,protein tyrosine kinase ERK2, Gene Alternate Symbols: ERK,ERK2,ERT1,MAPK2,P41MAPK,P42MAPK,PRKM1,PRKM2,p38,p40,p41,p41mapk, mitogen-activated protein kinase 10 Gene Symbol: MAPK10 Gene Alternate Names: JNK3 alpha protein kinase,MAP kinase,c-Jun N-terminal kinase 3,c-Jun kinase 3,stress activated protein kinase JNK3,stress activated protein kinase beta, Gene Alternate Symbols: FLJ12099,FLJ33785,JNK3,JNK3A,MGC50974,P493F12,P54BSAPK,PRKM10,p493F12,p54bSAPK, mitogen-activated protein kinase 11 Gene Symbol: MAPK11 Gene Alternate Names: mitogen-activated protein kinase p38-2,mitogen-activated protein kinase p38beta,stress-activated protein kinase-2,stress-activated protein kinase-2b, Gene Alternate Symbols: P38-2,P38B,P38BETA,P38BETA2,PRKM11,SAPK2,SAPK2B,p38-2,p38Beta, mitogen-activated protein kinase 12 Gene Symbol: MAPK12 Gene Alternate Names: mitogen-activated protein kinase 3,p38gamma,stress-activated protein kinase 3, Gene Alternate Symbols: ERK3,ERK6,P38GAMMA,PRKM12,SAPK-3,SAPK3,p38gamma, mitogen-activated protein kinase 13 Gene Symbol: MAPK13 Gene Alternate Names: mitogen-activated protein kinase p38 delta,stress-activated protein kinase 4, Gene Alternate Symbols: MGC99536,P38DELTA,PRKM13,SAPK4,p38delta, mitogen-activated protein kinase 14 Gene Symbol: MAPK14 Gene Alternate Names: Csaids binding protein,MAP kinase Mxi2,MAX-interacting protein 2,cytokine suppressive anti-inflammatory drug binding protein,p38 MAP kinase,p38 mitogen activated protein kinase,p38alpha Exip,stress-activated protein kinase 2A, Gene Alternate Symbols: CSBpgkb,CSBpmid,CSPB1,EXIP,MXI2,Mxi2,PRKM14,PRKM15,RK,SAPK2A,p38,p38ALPHA, mitogen-activated protein kinase 3 Gene Symbol: MAPK3 Gene Alternate Names: p44),p44erk1,p44mapk,protein kinase, mitogen-activated 3 (MAP kinase 3, Gene Alternate Symbols: ERK1,HS44KDAP,HUMKER1A,MGC20180,P44ERK1,P44MAPK,PRKM3,p44erk1,p44mapk, mitogen-activated protein kinase 4 Gene Symbol: MAPK4 Gene Alternate Names: Erk3-related,p63),protein kinase, mitogen-activated 4 (MAP kinase 4, Gene Alternate Symbols: ERK3,ERK3-RELATED,Erk3-related,Erk4,PRKM4,p63MAPK, mitogen-activated protein kinase 6 Gene Symbol: MAPK6 Gene Alternate Names: MAP kinase isoform p97,extracellular signal-regulated kinase 3,extracellular signal-regulated kinase, p97,protein kinase, mitogen-activated 5,protein kinase, mitogen-activated 6, Gene Alternate Symbols: DKFZp686F03189,ERK3,HsT17250,P97MAPK,PRKM6,p97MAPK, mitogen-activated protein kinase 7 Gene Symbol: MAPK7 Gene Alternate Names: BMK1 kinase,extracellular-signal-regulated kinase 5, Gene Alternate Symbols: BMK1,ERK4,ERK5,PRKM7, mitogen-activated protein kinase 9 Gene Symbol: MAPK9 Gene Alternate Names: Jun kinase,MAP kinase 9,c-Jun N-terminal kinase 2,c-Jun kinase 2,stress-activated protein kinase JNK2, Gene Alternate Symbols: JNK-55,JNK2,JNK2A,JNK2ALPHA,JNK2B,JNK2BETA,Jun kinase,P54ASAPK,PRKM9,p54aSAPK, MYC associated factor X Gene Symbol: MAX Gene Alternate Names: MAX protein,helix-loop-helix zipper protein,myc-associated factor X, Gene Alternate Symbols: MGC10775,MGC11225,MGC18164,MGC34679,MGC36767,orf1, methylcrotonoyl-Coenzyme A carboxylase 2 (beta) Gene Symbol: MCCC2 Gene Alternate Names: biotin carboxylase,non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase, Gene Alternate Symbols: MCCB, methyl CpG binding protein 2 (Rett syndrome) Gene Symbol: MECpmid Gene Alternate Names: mental retardation, X-linked 16,mental retardation, X-linked 79, Gene Alternate Symbols: AUTSX3,DKFZp686A24160,MRX16,MRX79,PPMX,RTS,RTT, met proto-oncogene (hepatocyte growth factor receptor) Gene Symbol: MET Gene Alternate Names: Oncogene MET, Gene Alternate Symbols: HGFR,RCCpmid, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A Gene Symbol: MGAT4A Gene Alternate Names: UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase,alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase,mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A, Gene Alternate Symbols: GNT-IV,GNT-IVA,GnT-Iva, MHC class I polypeptide-related sequence A Gene Symbol: MICA Gene Alternate Symbols: MGC111087,PERB11.1,truncated, M-phase phosphoprotein 9 Gene Symbol: MPHOSPH9 Gene Alternate Names: M phase phosphoprotein 9, Gene Alternate Symbols: DKFZp434J034,FLJ12954,MPP-9,MPP9, mitochondrial ribosomal protein L33 Gene Symbol: MRPL33 Gene Alternate Names: chromosome 2 open reading frame 1,ribosomal protein L33-like, Gene Alternate Symbols: C2ORF1,C2orf1,MGC111093,MGC13694,MGC23922,RPL33L, adducin 1 (alpha) Gene Symbol: ADD1 Gene Alternate Names: erythrocyte adducin alpha subunit, Gene Alternate Symbols: ADDA,MGC3339,MGC44427, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Gene Symbol: SLC6A2 Gene Alternate Names: Human noradrenaline transporter mRNA, complete cds.,NAT1,NET,NET1,SLC6A5,Solute carrier family 6 (neurotransmitter transporter, noradrenalin),,noradrenaline transporter,norepinephrine transporter,solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5, Gene Alternate Symbols: M65105.1,NAT1,NET,NET1,SLC6A2,SLC6A5, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Gene Symbol: SLC6A3 Gene Alternate Names: DAT,DAT1,Homo sapiens dopamine transporter mRNA, complete cds.,Solute carrier family 6 (neurotransmitter transporter, dopamine),,dopamine transporter,variable number tandem repeat (VNTR), Gene Alternate Symbols: DAT,DAT1,L24178.1,SLC6A3, mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) Gene Symbol: MSH2 Gene Alternate Names: mutS (E. coli) homolog 2,mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1), Gene Alternate Symbols: COCA1,FCC1,HNPCC,HNPCC1, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene Symbol: SLC6A4 Gene Alternate Names: 5-HTT,5-hydroxytryptamine transporter,5HT transporter,5HTT,HTT,Na+/Cl- dependent serotonin transporter,OCD1,SERT,Solute carrier family 6 (neurotransmitter transporter, serotonin),,hSERT,sodium-dependent serotonin transporter, Gene Alternate Symbols: 5-HTT,5HTT,HTT,OCD1,SERT,SLC6A4,hSERT, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase Gene Symbol: MTHFD1 Gene Alternate Names: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase,C1-THF synthase,NADP-dependent cyclohydrolase/formyltetrahydrofolate synthetase,cytoplasmic C-1-tetrahydrofolate synthase,methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, Gene Alternate Symbols: MTHFC,MTHFD, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Gene Symbol: MTHFD2 Gene Alternate Names: NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase,methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase, Gene Alternate Symbols: NMDMC, 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) Gene Symbol: MTHFS Gene Alternate Symbols: HsT19268, 5-methyltetrahydrofolate-homocysteine methyltransferase Gene Symbol: MTR Gene Alternate Names: 5-methyltetrahydrofolate-homocysteine methyltransferase 1,methionine synthase, Gene Alternate Symbols: FLJ45386,MS, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Gene Symbol: MTRR Gene Alternate Names: [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing), Gene Alternate Symbols: MGC129643,MSR, muscle, skeletal, receptor tyrosine kinase Gene Symbol: MUSK Gene Alternate Names: Receptor tyrosine kinase MuSK, Gene Alternate Symbols: MGC126323,MGC126324, v-myb myeloblastosis viral oncogene homolog (avian) Gene Symbol: MYB Gene Alternate Names: Avian myeloblastosis viral (v-myb) oncogene homolog,c-myb,v-myb avian myeloblastosis viral oncogene homolog, Gene Alternate Symbols: c-myb,c-myb_CDS,efg, myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) Gene Symbol: MYH6 Gene Alternate Names: myosin heavy chain, cardiac muscle alpha isoform, Gene Alternate Symbols: ASD3,MYHC,MYHCA,alpha-MHC, myosin, heavy polypeptide 7, cardiac muscle, beta Gene Symbol: MYH7 Gene Alternate Names: myopathy, distal 1, Gene Alternate Symbols: CMD1S,CMH1,MGC138376,MGC138378,MPD1,MYHCB, myosin, light polypeptide kinase Gene Symbol: MYLK Gene Alternate Names: myosin light chain kinase, Gene Alternate Symbols: DKFZp686I10125,FLJ12216,KRP,MLCK,MLCK108,MLCK210,MSTP083, natural killer cell group 7 sequence Gene Symbol: NKG7 Gene Alternate Symbols: GIG1, N-myristoyltransferase 1 Gene Symbol: NMT1 Gene Alternate Symbols: NMT, neuropeptide FF-amide peptide precursor Gene Symbol: NPFF Gene Alternate Names: FMFRamide-related peptide precursor, Gene Alternate Symbols: FMRFAL, NAD(P)H dehydrogenase, quinone 1 Gene Symbol: NQO1 Gene Alternate Names: DHQU,DTD,NAD(P)H:menadione oxidoreductase 1, dioxin-inducible 1,NMOR1,QR1,diaphorase (NADH/NADPH),diaphorase (NADH/NADPH) (cytochrome b-5 reductase),diaphorase-4, Gene Alternate Symbols: DHQU,DIA4,DTD,NMOR1,NMORI,QR1, neuropilin 1 Gene Symbol: NRpgkb Gene Alternate Symbols: CD304,DKFZp686A03134,DKFZp781F1414,NRP,VEGF165R, neurexin 2 Gene Symbol: NRXN2 Gene Alternate Names: neurexin II, Gene Alternate Symbols: KIAA0921, nucleoporin 98kDa Gene Symbol: NUP98 Gene Alternate Names: GLFG-repeat containing nucleoporin,Nup98-Nup96 precursor,nucleoporin 98kD, Gene Alternate Symbols: ADIR2,NUpgkb96, 8-oxoguanine DNA glycosylase Gene Symbol: OGG1 Gene Alternate Names: 8-hydroxyguanine DNA glycosylase, Gene Alternate Symbols: HMMH,HOGG1,MUTM,OGH1, opioid receptor, mu 1 Gene Symbol: OPRM1 Gene Alternate Symbols: KIAA0403,MOR-1,MOR1,OPRM, solute carrier family 18 (vesicular monoamine), member 1 Gene Symbol: SLC18A1 Gene Alternate Names: ADRENAL CHROMAFFIN GRANULE AMINE TRANSPORTER; CGAT,CGAT,Human vesicular monoamine transporter VMAT1 mRNA, complete cds..,SOLUTE CARRIER FAMILY 18, MEMBER 1; SLC18A1,VAT1,VESICULAR AMINE TRANSPORTER 1; VAT1,VESICULAR MONOAMINE TRANSPORTER 1; VMAT1,VMAT1, Gene Alternate Symbols: CGAT,SLC18A1,U39905.1,VAT1,VMAT1, solute carrier family 18 (vesicular monoamine), member 2 Gene Symbol: SLC18A2 Gene Alternate Names: MGC120477,MGC120478,MGC26538,SOLUTE CARRIER FAMILY 18, MEMBER 2; SLC18A2,SVAT,SVMT,SYNAPTIC VESICLE AMINE TRANSPORTER, BRAIN; SVAT,SYNAPTIC VESICLE MONOAMINE TRANSPORTER, BRAIN; SVMT,VAT2,VESICULAR AMINE TRANSPORTER 2; VAT2,VESICULAR MONOAMINE TRANSPORTER 2; VMAT2,VMAT2, Gene Alternate Symbols: L23205.1,MGC120477,MGC120478,MGC26538,SLC18A2,SVAT,SVMT,VAT2,VMAT2,VMAT2-PSG, solute carrier family 19 (folate transporter), member 1 Gene Symbol: SLC19A1 Gene Alternate Names: CHMD,FOLATE TRANSPORTER; FOLT,FOLT,IFC1,INTESTINAL FOLATE CARRIER 1; IFC1,REDUCED FOLATE CARRIER 1; RFC1,REFC,RFC1,Reduced Folate Carrier,SOLUTE CARRIER FAMILY 19, MEMBER 1; SLC19A1,homologue of mutant Chinese hamster cell methotrexate uptake deficiency,human reduced folate carrier (RFC), Gene Alternate Symbols: CHMD,FOLT,IFC1,NM_003056.1,REFC,RFC1,SLC19A1, solute carrier organic anion transporter family, member 1A2 Gene Symbol: SLCO1A2 Gene Alternate Names: OATP,OATP-A,OATpgkbA2,ORGANIC ANION TRANSPORTER; OATP,SLC21A3,SOLUTE CARRIER FAMILY 21, MEMBER 3; SLC21A3,organic anion transporting polypeptide A,sodium-independent organic anion transporter,solute carrier family 21 (organic anion transporter), member 3, Gene Alternate Symbols: NM_021094.1,OATP,OATP-A,OATpgkbA2,SLC21A3,SLCO1A2, solute carrier family 22 (organic cation transporter), member 1 Gene Symbol: SLC22A1 Gene Alternate Names: HOCT1,Homo sapiens organic cation transporter 1 (hOCT1) mRNA, complete cds.,OCT1,oct1_cds,organic cation transporter 1, Gene Alternate Symbols: HOCT1,OCT1,SLC22A1,U77086.1,oct1_cds, poly (ADP-ribose) glycohydrolase Gene Symbol: PARG Gene Alternate Symbols: PARG99, paired box gene 5 (B-cell lineage specific activator) Gene Symbol: PAX5 Gene Alternate Names: B-cell lineage specific activator protein,paired box gene 5 (B-cell lineage specific activator protein),paired box homeotic gene 5 (B-cell lineage specific activator protein), Gene Alternate Symbols: BSAP, protocadherin 9 Gene Symbol: PCDH9 Gene Alternate Names: cadherin superfamily protein VR4-11, solute carrier family 22 (organic cation transporter), member 2 Gene Symbol: SLC22A2 Gene Alternate Names: Homo sapiens mRNA for organic cation transporter, kidney.,MGC32628,OCT2,organic cation transporter (OCT2),organic cation transporter 2, Gene Alternate Symbols: MGC32628,OCT2,SLC22A2,X98333.1, phosphodiesterase 10A Gene Symbol: PDE10A Gene Alternate Symbols: FLJ11894,HSPDE10A, phosphodiesterase 11A Gene Symbol: PDE11A Gene Alternate Names: cyclic nucleotide phosphodiesterase 11A1, Gene Alternate Symbols: FLJ23693,MGC133355,MGC133356,PDE11A1,PDE11A2,PDE11A3, phosphodiesterase 1A, calmodulin-dependent Gene Symbol: PDE1A Gene Alternate Names: Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1A3A),Phosphodiesterase-1A, Gene Alternate Symbols: HCAM1,HSPDE1A,MGC26303, phosphodiesterase 1B, calmodulin-dependent Gene Symbol: PDE1B Gene Alternate Names: Phosphodiesterase-1B,phosphodiesterase IB,phosphodiesterase IB, calmodulin-dependent, Gene Alternate Symbols: PDE1B1,PDES1B, phosphodiesterase 2A, cGMP-stimulated Gene Symbol: PDE2A Gene Alternate Names: Human cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase PDE2A3 (PDE2A) mRNA, complete cds, Gene Alternate Symbols: PDE2A1,PED2A4, phosphodiesterase 3A, cGMP-inhibited Gene Symbol: PDE3A Gene Alternate Symbols: CGI-PDE, phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) Gene Symbol: PDE4A Gene Alternate Names: Phosphodiesterase-4A, cAMP-specific (dunce (Drosophila)-homolog,cyclic AMP-specific phosphodiesterase HSPDE4A10,phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2),phosphodiesterase isozyme 4, Gene Alternate Symbols: DPDE2,PDE4, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) Gene Symbol: PDE4B Gene Alternate Names: Phosphodiesterase-4B, cAMP-specific (dunce (Drosophila)-homolog,phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4), Gene Alternate Symbols: DKFZp686F2182,DPDE4,MGC126529,PDEIVB, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) Gene Symbol: PDE4D Gene Alternate Names: Phosphodiesterase-4D, cAMP-specific (dunce (Drosophila)-homolog,cyclic AMP phosphodiesterase,dunce-like phosphodiesterase E3,phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3), Gene Alternate Symbols: DPDE3,HSPDE4D,PDE4DN2,STRK1, phosphodiesterase 5A, cGMP-specific Gene Symbol: PDE5A Gene Alternate Names: cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase, Gene Alternate Symbols: CGB-PDE,CN5A,PDE5,PDE5A1, phosphodiesterase 6A, cGMP-specific, rod, alpha Gene Symbol: PDE6A Gene Alternate Symbols: CGPR-A,PDEA, phosphodiesterase 6C, cGMP-specific, cone, alpha prime Gene Symbol: PDE6C Gene Alternate Symbols: PDEA2, phosphodiesterase 6D, cGMP-specific, rod, delta Gene Symbol: PDE6D Gene Alternate Symbols: PDED, phosphodiesterase 6G, cGMP-specific, rod, gamma Gene Symbol: PDE6G Gene Alternate Symbols: DKFZp686C0587,MGC125749,PDEG, phosphodiesterase 7A Gene Symbol: PDE7A Gene Alternate Symbols: HCpgkb,PDE7, phosphodiesterase 7B Gene Symbol: PDE7B Gene Alternate Symbols: MGC88256,bA472E5.1, phosphodiesterase 8A Gene Symbol: PDE8A Gene Alternate Names: cAMP-specific cyclic nucleotide phosphodiesterase 8A,high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, Gene Alternate Symbols: FLJ16150,HsT19550, phosphodiesterase 8B Gene Symbol: PDE8B Gene Alternate Names: 3',5' cyclic nucleotide phosphodiesterase 8B, Gene Alternate Symbols: FLJ11212, platelet factor 4 variant 1 Gene Symbol: PF4V1 Gene Alternate Names: Platelet factor 4, variant 1 (PF4-like), Gene Alternate Symbols: CXCL4V1,PF4-ALT,PF4A,SCYB4V1, phosphatidylinositol glycan anchor biosynthesis, class F Gene Symbol: PIGF Gene Alternate Names: phosphatidylinositol glycan, class F, Gene Alternate Symbols: MGC32646,MGC33136, phosphoinositide-3-kinase, class 2, alpha polypeptide Gene Symbol: PIK3C2A Gene Alternate Names: C2-containing phosphatidylinositol kinase, Gene Alternate Symbols: CPK,DKFZp686L193,MGC142218,PI3-K-C2(ALPHA),PI3-K-C2A,PI3K-C2alpha, phosphoinositide-3-kinase, class 2, beta polypeptide Gene Symbol: PIK3C2B Gene Alternate Names: PI3K-C2beta,PTDINS-3-kinase C2 beta,phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide, Gene Alternate Symbols: C2-PI3K,DKFZp686G16234,PI3K-C2beta, phospholipase C, beta 1 (phosphoinositide-specific) Gene Symbol: PLCB1 Gene Alternate Names: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1,KIAA0581,PLC-beta-1,inositoltrisphosphohydrolase,monophosphatidylinositol phosphodiesterase,phosphoinositidase C,phosphoinositide-specific phospholipase C-beta 1,phospholipase C beta 1,phospholipase C, beta 1(phosphoinositide-specific),triphosphoinositide phosphodiesterase, Gene Alternate Symbols: FLJ45792,KIAA0581,PI-PLC,PLC-154,PLC-I, phospholipase C, beta 2 Gene Symbol: PLCB2 Gene Alternate Symbols: FLJ38135, phospholipase C, beta 3 (phosphatidylinositol-specific) Gene Symbol: PLCB3 phospholipase C, beta 4 Gene Symbol: PLCB4 Gene Alternate Symbols: FLJ16169,PI-PLC, phospholipase C, delta 1 Gene Symbol: PLCD1 phospholipase C, delta 3 Gene Symbol: PLCD3 Gene Alternate Names: PLC delta3, phospholipase C, delta 4 Gene Symbol: PLCD4 Gene Alternate Names: PLC delta4, Gene Alternate Symbols: MGC12837, phospholipase C, epsilon 1 Gene Symbol: PLCE1 Gene Alternate Names: pancreas-enriched phospholipase C, Gene Alternate Symbols: FLJ23659,KIAA1516,PLCE, phospholipase C, gamma 1 Gene Symbol: PLCG1 Gene Alternate Names: phospholipase C, gamma 1 (formerly subtype 148), Gene Alternate Symbols: PLC-II,PLC1,PLC148,PLCgamma1, phospholipase C, gamma 2 (phosphatidylinositol-specific) Gene Symbol: PLCG2 Gene Alternate Names: Phospholipase C, gamma 2 (phosphatidylyinositol-specific), phospholipase C-like 1 Gene Symbol: PLCL1 Gene Alternate Names: phospholipase C, epsilon, Gene Alternate Symbols: MGC126580,MGC138190,PLC-L,PLCE,PLCL,PLDL1, phospholipase C-like 2 Gene Symbol: PLCL2 Gene Alternate Names: phospholipase C, epsilon 2, Gene Alternate Symbols: FLJ13484,KIAA1092,PLCE2, superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) Gene Symbol: SOD1 Gene Alternate Names: Cu/Zn superoxide dismutase,Superoxide dismutase-1, soluble, Gene Alternate Symbols: ALS,ALS1,IPOA,SOD,homodimer, plastin 1 (I isoform) Gene Symbol: PLS1 Gene Alternate Names: I isoform,I-plastin,Plastin-1, Gene Alternate Symbols: I-PLASTIN,I-plastin, phosphomevalonate kinase Gene Symbol: PMVK Gene Alternate Symbols: HUMPMKI,PMK,PMKA,PMKASE, paraoxonase 1 Gene Symbol: PON1 Gene Alternate Names: Paraoxonase, Gene Alternate Symbols: ESA,PON, P450 (cytochrome) oxidoreductase Gene Symbol: POR Gene Alternate Names: Cytochrome P-450 reductase, Gene Alternate Symbols: CPR,CYPOR,DKFZp686G04235,P450R, phosphoribosyl pyrophosphate amidotransferase Gene Symbol: PPAT Gene Alternate Names: acyltransferase,amidophosphoribosyltransferase,glutamine PRPP amidotransferase,glutamine phosphoribosylpyrophosphatate amidotransferase,glycerol-3-phosphate,mitochondrial, Gene Alternate Symbols: ATASE,GPAT, protein phosphatase 1, catalytic subunit, beta isoform Gene Symbol: PPpgkbCB Gene Alternate Symbols: MGC3672,PP-1B,PPpgkbCD, protein phosphatase 1, regulatory (inhibitor) subunit 15A Gene Symbol: PPpgkbR15A Gene Alternate Names: growth arrest and DNA-damage-inducible 34, Gene Alternate Symbols: GADD34, signal transducer and activator of transcription 3 (acute-phase response factor) Gene Symbol: STAT3 Gene Alternate Names: APRF,DNA-binding protein APRF,acute-phase response factor, Gene Alternate Symbols: APRF,FLJ20882,MGC16063, prolylcarboxypeptidase (angiotensinase C) Gene Symbol: PRCP Gene Alternate Names: angiotensinase C, Gene Alternate Symbols: HUMPCP,MGC2202,PCP, PR domain containing 2, with ZNF domain Gene Symbol: PRDM2 Gene Alternate Names: MTE-binding protein,retinoblastoma protein-binding zinc finger protein,retinoblastoma protein-interacting zinc finger protein,zinc-finger DNA-binding protein, Gene Alternate Symbols: HUMHOXY1,MTB-ZF,RIZ,RIZ1,RIZ2, perforin 1 (pore forming protein) Gene Symbol: PRF1 Gene Alternate Names: Perforin,perforin 1 (preforming protein), Gene Alternate Symbols: FLH2,HPLH2,MGC65093,pgkb,PFP, proteoglycan 1, secretory granule Gene Symbol: PRG1 Gene Alternate Names: Proteoglycan 1, secretory granule (platelet proteoglycan protein core),serglycin, Gene Alternate Symbols: FLJ12930,MGC9289,PPG,PRG,SERGLYCIN, protein kinase C, beta 1 Gene Symbol: PRKCB1 Gene Alternate Names: Protein kinase C, beta 1 polypeptide, Gene Alternate Symbols: MGC41878,PKC-beta,PKCB,PRKCB,PRKCB2, protein kinase N2 Gene Symbol: PKN2 Gene Alternate Names: PRK2,protein kinase C-like 2, Gene Alternate Symbols: MGC71074,PRK2,PRKCL2,PRO2042,Pak-2, protein kinase C, theta Gene Symbol: PRKCQ Gene Alternate Symbols: MGC126514,MGC141919,PRKCT,nPKC-theta, WNK lysine deficient protein kinase 1 Gene Symbol: WNK1 Gene Alternate Names: kinase deficient protein,protein kinase, lysine deficient 1, Gene Alternate Symbols: KDP,KIAA0344,PHA2C,PRKWNK1, protein kinase, Y-linked Gene Symbol: PRKY proteasome (prosome, macropain) 26S subunit, ATPase, 1 Gene Symbol: PSMC1 Gene Alternate Names: 26S protease regulatory subunit 4,proteasome 26S subunit, ATPase, 1, Gene Alternate Symbols: MGC24583,MGC8541,pmid6S4,P56S4,S4,p56, phosphatase and tensin homolog (mutated in multiple advanced cancers 1) Gene Symbol: PTEN Gene Alternate Names: Bannayan-Zonana syndrome,multiple hamartoma (Cowden syndrome),mutated in multiple advanced cancers 1, Gene Alternate Symbols: BZS,MGC11227,MHAM,MMAC1,PTEN1,TEpgkb, PTK7 protein tyrosine kinase 7 Gene Symbol: PTK7 Gene Alternate Names: PTK7 protein tyrosine kinase,colon carcinoma kinase-4,protein-tyrosine kinase PTK7, Gene Alternate Symbols: CCK4, protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) Gene Symbol: PTPN11 Gene Alternate Names: Noonan syndrome 1,protein tyrosine phosphatase, non-receptor type 11,protein-tyrosine phosphatase 2C, Gene Alternate Symbols: BPTP3,CFC,MGC14433,NS1,PTP-1D,PTpmidC,SH-PTpmid,SH-PTP3,SHP-2,SHpmid, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Gene Symbol: PTPN22 Gene Alternate Names: lymphoid-specific protein tyrosine phosphatase,protein tyrosine phosphatase homolog,protein tyrosine phosphatase, non-receptor type 8, Gene Alternate Symbols: LYP,LYpgkb,LYpmid,Lyp,Lypgkb,Lypmid,PEP,PTPN8, adrenergic, alpha-1A-, receptor Gene Symbol: ADRA1A Gene Alternate Names: adrenergic, alpha -1A-, receptor,adrenergic, alpha-1A-, receptor (NOTE: redefinition of symbol),adrenergic, alpha-1C-, receptor, Gene Alternate Symbols: ADRA1C,ADRA1L1,ALPHA1AAR, sulfotransferase family 1E, estrogen-preferring, member 1 Gene Symbol: SULT1E1 Gene Alternate Names: EST,estrogen sulfotransferase,estrone sulfotransferase,sulfotransferase, estrogen-preferring, Gene Alternate Symbols: EST,EST-1,MGC34459,STE, protein tyrosine phosphatase, receptor type, C Gene Symbol: PTPRC Gene Alternate Names: CD45 antigen,SCID due to PTPRC deficiency,T200 glycoprotein,human homolog of severe combined immunodeficiency due to PTPRC deficiency,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide, Gene Alternate Symbols: B220,CD45,Gpgkb80,LCA,LY5,T200, protein tyrosine phosphatase, receptor type, G Gene Symbol: PTPRG Gene Alternate Names: protein tyrosine phosphatase gamma,protein tyrosine phosphatase, receptor type, gamma polypeptide,receptor tyrosine phosphatase gamma,receptor-type protein phosphatase gamma, Gene Alternate Symbols: HPTPG,PTPG,R-PTP-GAMMA,RPTPG, 6-pyruvoyltetrahydropterin synthase Gene Symbol: PTS Gene Alternate Symbols: PTPS, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 Gene Symbol: SULT1A2 Gene Alternate Names: HAST4,aryl sulfotransferase,arylamine sulfotransferase,phenol-preferring phenol sulfotransferase2,phenol-sulfating phenol sulfotransferase 2,phenolic-metabolizing (P) form of PST,sulfotransferase family 1A, phenol-preferring, member 2,thermostable phenol sulfotransferase, Gene Alternate Symbols: HAST4,MGC142287,MGC142289,P-PST,ST1A2,STpmid,TSPST2, RAB31, member RAS oncogene family Gene Symbol: RAB31 Gene Alternate Symbols: RAB22B,Rab22B, RAB5C, member RAS oncogene family Gene Symbol: RAB5C Gene Alternate Names: RAB, member of RAS oncogene family-like,RAB5C, member of RAS oncogene family, Gene Alternate Symbols: MGC117217,MGC138857,RAB5CL,RABL, RAD52 homolog (S. cerevisiae) Gene Symbol: RAD52 Gene Alternate Names: DNA repair protein RAD52,RAD52 (S. cerevisiae) homolog,recombination protein RAD52, v-raf-1 murine leukemia viral oncogene homolog 1 Gene Symbol: RAF1 Gene Alternate Names: Oncogene RAF1,raf proto-oncogene serine/threonine protein kinase, Gene Alternate Symbols: CRAF,Raf-1,c-Raf, ralA binding protein 1 Gene Symbol: RALBpgkb Gene Alternate Names: ralA-binding protein, Gene Alternate Symbols: RIP,RIpgkb,RLIP76, retinoblastoma binding protein 8 Gene Symbol: RBBP8 Gene Alternate Names: CTBP-interacting protein CtIP,Rim,retinoblastoma-binding protein 8,retinoblastoma-interacting myosin-like, Gene Alternate Symbols: CTIP,RIM, RNA binding motif protein, X-linked Gene Symbol: RBMX Gene Alternate Names: RNA binding motif protein, X chromosome, Gene Alternate Symbols: HNRPG,RBMXpgkb,RBMXRT,RNMX,hnRNP-G, retinol binding protein 4, plasma Gene Symbol: RBP4 Gene Alternate Names: retinol-binding protein 4, interstitial,retinol-binding protein 4, plasma, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 Gene Symbol: SULT1A1 Gene Alternate Names: P-PST,aryl sulfotransferase,phenol-preferring phenol sulfotransferase1,phenol-sulfating phenol sulfotransferase,sulfotransferase family 1A, phenol-preferring, member 1,thermostable phenol sulfotransferase1, Gene Alternate Symbols: HAST1/HAST2,MGC131921,MGC5163,P-PST,PST,ST1A3,STP,STpgkb,TSPST1, radixin Gene Symbol: RDX regulator of G-protein signalling 4 Gene Symbol: RGS4 Gene Alternate Names: RGP4, Gene Alternate Symbols: MGC2124,MGC60244,RGP4,SCZD9, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 Gene Symbol: SULT1A3 Gene Alternate Names: TL-PST,aryl sulfotransferase,catecholamine-sulfating phenol sulfotransferase,monoamine-preferring sulfotransferase,monoamine-sulfating phenosulfotransferase,placental estrogen sulfotransferase,sulfotransferase family 1A, phenol-preferring, member 3,thermolabile (monoamine, M form) phenol sulfotransferase,thermolabile phenol sulfotransferase, Gene Alternate Symbols: HAST,HAST3,M-PST,MGC117469,STM,SULT1A4,TL-PST, ribonuclease, RNase A family, k6 Gene Symbol: RNASE6 Gene Alternate Names: RNase k6, Gene Alternate Symbols: RNASEK6,RNS6,RNase,RNase k6,RNasek6,k6, sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 Gene Symbol: SULT2A1 Gene Alternate Names: DHEA-ST,alcohol sulfotransferase,alcohol/hydroxysteroid sulfotransferase,dehydroepiandrosterone sulfotransferase,hydroxysteroid sulfotransferase,sulfotransferase family 2A, dehydroepiandrosterone (DHEA) -preferring, member 1,sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1,sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1, Gene Alternate Symbols: DHEA-ST,HST,ST2,ST2A3,STD,hSTa, ribosomal protein L5 Gene Symbol: RPL5 Gene Alternate Names: 60S ribosomal protein L5, Gene Alternate Symbols: MGC117339,MSTP030, runt-related transcription factor 3 Gene Symbol: RUNX3 Gene Alternate Names: core-binding factor, runt domain, alpha subunit 3, Gene Alternate Symbols: AML2,CBFA3,FLJ34510,MGC16070,PEBpmidA3,PEBpmidaC, RuvB-like 2 (E. coli) Gene Symbol: RUVBL2 Gene Alternate Names: Reptin52,RuvB (E coli homolog)-like 2,TBP-interacting protein, 48-KD,erythrocyte cytosolic protein, 51-KD, Gene Alternate Symbols: CGI-46,ECP51,RVB2,TIP48,TIP49B,TIP49b, S100 calcium binding protein A12 (calgranulin C) Gene Symbol: S100A12 Gene Alternate Names: S100 calcium binding protein A12,S100 calcium-binding protein A12 (calgranulin C),calgranulin C, Gene Alternate Symbols: CAAF1,CAGC,CGRP,ENRAGE,MRP6,P6,p6, S100 calcium binding protein A8 (calgranulin A) Gene Symbol: S100A8 Gene Alternate Names: S100 calcium-binding protein A8 (calgranulin A),calgranulin A,cystic fidlsis antigen, Gene Alternate Symbols: 60B8AG,CAGA,CFAG,CGLA,CP-10,L1Ag,MA387,MIF,MRP8,NIF,P8, S100 calcium binding protein A9 (calgranulin B) Gene Symbol: S100A9 Gene Alternate Names: S100 calcium-binding protein A9 (calgranulin B),calgranulin B, Gene Alternate Symbols: 60B8AG,CAGB,CFAG,CGLB,L1AG,LIAG,MAC387,MIF,MRpgkb4,NIF,pgkb4, serum amyloid A1 Gene Symbol: SAA1 Gene Alternate Names: Acute phase Serum Amyloid A,Amyloid A,glucocorticoid-inducible SAA,tumor protein p53 inducible protein 4, Gene Alternate Symbols: A-SAA,A-SAA1,ASAA,MGC111216,PIG4,SAA,TP53I4, serum amyloid A2 Gene Symbol: SAA2 Gene Alternate Names: Acute phase Serum Amyloid A,AmyloidA, Gene Alternate Symbols: A-SAA,A-SAA2,ASAA,SAA, spastic ataxia of Charlevoix-Saguenay (sacsin) Gene Symbol: SACS Gene Alternate Symbols: ARSACS,DKFZp686B15167,KIAA0730, Sin3A-associated protein, 18kDa Gene Symbol: SApgkb8 Gene Alternate Names: sin3-associated polypeptide, 18kD,sin3-associated polypeptide, 18kDa,sin3A-associated protein, 18kDa, Gene Alternate Symbols: 2HOR0202,MGC27131,SApgkb8p, adrenergic, alpha-2A-, receptor Gene Symbol: ADRA2A Gene Alternate Names: ADRAR,OTTHUMP00000058849,alpha-2AAR subtype C10, Gene Alternate Symbols: ADRA2,ADRA2R,ADRAR,ALPHA2AAR,ZNF32, actin binding LIM protein 1 Gene Symbol: ABLIM1 Gene Alternate Names: LIM actin-binding protein 1,actin-binding LIM protein,limatin, Gene Alternate Symbols: ABLIM,DKFZp781D0148,FLJ14564,KIAA0059,LIMAB1,LIMATIN,MGC1224,abLIM,limatin, ADP-ribosylation factor GTPase activating protein 3 Gene Symbol: ARFGAP3 Gene Alternate Names: ADP-ribosylation factor GTPase activating protein 1, Gene Alternate Symbols: ARFGApgkb, major histocompatibility complex, class I, C Gene Symbol: HLA-C Gene Alternate Names: Cw1 antigen,HLA class I histocompatibility antigen, C alpha chain, Gene Alternate Symbols: Cw*1701,D6S204,FLJ27082,HLA-JY3,HLC-C,PSORS1, major histocompatibility complex, class II, DR beta 1 Gene Symbol: HLA-DRB1 Gene Alternate Names: HLA DRB1,HLA class II histocompatibility antigen, DR-1 beta chain, Gene Alternate Symbols: DRB1,HLA-DR1B, HLA-G histocompatibility antigen, class I, G Gene Symbol: HLA-G Gene Alternate Names: HLA-G histocompatibility antigen, class I,major histocompatibility complex, class I, G, Gene Alternate Symbols: HLA-6.0,HLA60,MHC-G,TCA, tyrosine hydroxylase Gene Symbol: TH Gene Alternate Symbols: TYH, thymidine kinase 1, soluble Gene Symbol: TK1 Gene Alternate Names: Thymidine kinase-1, Gene Alternate Symbols: TK2, topoisomerase (DNA) I Gene Symbol: TOpgkb Gene Alternate Names: type I DNA topoisomerase, Gene Alternate Symbols: TOPI, topoisomerase (DNA) II alpha 170kDa Gene Symbol: TOpmidA Gene Alternate Names: DNA topoisomerase II, 170 kD,topoisomerase (DNA) II alpha (170kD), Gene Alternate Symbols: TOpmid,TpmidA, tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) Gene Symbol: TPH1 Gene Alternate Names: tryptophan hydroxylase (tryptophan 5-monooxygenase), Gene Alternate Symbols: MGC119994,TPH,TPRH, thiopurine S-methyltransferase Gene Symbol: TPMT selectin P (granule membrane protein 140kDa, antigen CD62) Gene Symbol: SELP Gene Alternate Names: Selectin P (granulocyte membrane protein, 140kD,antigen CD62,antigen CD62),selectin P (granule membrane protein 140kD, antigen CD62), Gene Alternate Symbols: CD62,CD62P,FLJ45155,GMpgkb40,GRMP,PADGEM,PSEL, serine hydroxymethyltransferase 1 (soluble) Gene Symbol: SHMT1 Gene Alternate Names: cytoplasmic serine hydroxymethyltransferase, Gene Alternate Symbols: CSHMT,MGC15229,MGC24556,SHMT, solute carrier organic anion transporter family, member 1B3 Gene Symbol: SLCO1B3 Gene Alternate Names: LST-3TM13,LST3,OATpgkbB3,OATP8,SLC21A8,liver-specific organic anion transporter 3TM13,solute carrier family 21 (organic anion transporter), member 8, Gene Alternate Symbols: LST-3TM13,LST3,OATpgkbB3,OATP8,SLC21A8,SLCO1B3, thymidylate synthetase Gene Symbol: TYMS Gene Alternate Names: HsT422,TMS,TYMS protein,Thymidylate synthase,Tsase, Gene Alternate Symbols: HsT422,MGC88736,TMS,TS,TSase,Tsase, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 Gene Symbol: SLC7A11 Gene Alternate Names: cystine/glutamate transporter, Gene Alternate Symbols: CCBR1,xCT, Smcy homolog, Y-linked (mouse) Gene Symbol: SMCY Gene Alternate Names: Jumonji, AT rich interactive domain 1D (RBpmid-like),SMC (mouse) homolog, Y chromosome,Selected mouse cDNA on Y, human homolog of,Smcy homolog, Y chromosome (mouse),histocompatibility Y antigen,selected mouse cDNA on Y, human homolog of, Gene Alternate Symbols: HY,HYA,JARID1D,KIAA0234, sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) Gene Symbol: SMPD1 Gene Alternate Names: acid sphingomyelinase,sphingomyelin phosphodiesterase-1, acid lysosomal, Gene Alternate Symbols: ASM,NPD, superoxide dismutase 2, mitochondrial Gene Symbol: SOD2 Gene Alternate Symbols: IPO-B,MNSOD,Mn-SOD, Spgkb transcription factor Gene Symbol: Spgkb v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Gene Symbol: SRC Gene Alternate Names: Protooncogene SRC, Rous sarcoma,protooncogene SRC, Rous sarcoma,tyrosine kinase pp60c-src,tyrosine-protein kinase SRC-1,v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog, Gene Alternate Symbols: ASV,SRC1,c-SRC,c-src,p60-Src, synovial sarcoma, X breakpoint 1 Gene Symbol: SSX1 Gene Alternate Names: SSX1 protein,sarcoma, synovial, X-chromosome-related 1, Gene Alternate Symbols: MGC5162,SSRC, synovial sarcoma translocation, chromosome 18 Gene Symbol: SS18 Gene Alternate Symbols: MGC116875,SSXT,SYT, suppression of tumorigenicity 14 (colon carcinoma) Gene Symbol: ST14 Gene Alternate Names: membrane-type serine protease,serine protease TADG-15,suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin),tumor associated differentially expressed gene 15 protein, Gene Alternate Symbols: HAI,MT-Spgkb,MTSP-1,MTSpgkb,PRSS14,SNC19,TADG-15, uridine-cytidine kinase 2 Gene Symbol: UCK2 Gene Alternate Names: NMP-kinase,nucleoside-phosphate kinase,uridine kinase,uridine monophosphate kinase, Gene Alternate Symbols: TSA903,UK,UMK,UMPK, serine/threonine kinase 24 (STE20 homolog, yeast) Gene Symbol: STK24 Gene Alternate Names: STE20-like kinase 3,serine/threonine kinase 24 (Ste20, yeast homolog),sterile 20-like kinase 3, Gene Alternate Symbols: MST-3,MST3,MST3B,STK3, sulfotransferase family, cytosolic, 2B, member 1 Gene Symbol: SULT2B1 Gene Alternate Names: 2B,HSST2,sulfotransferase,sulfotransferase family 2B, member 1, Gene Alternate Symbols: HSST2, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) Gene Symbol: TCF3 Gene Alternate Names: E2A immunoglobulin enhancer-binding factor E12/E47,immunoglobulin transcription factor 1,kappa-E2-binding factor,transcription factor E2-alpha, Gene Alternate Symbols: E2A,ITF1,MGC129647,MGC129648, transcription factor 7-like 2 (T-cell specific, HMG-box) Gene Symbol: TCF7L2 Gene Alternate Symbols: TCF-4,TCF4, transcobalamin I (vitamin B12 binding protein, R binder family) Gene Symbol: TCN1 Gene Alternate Names: haptocorrin, Gene Alternate Symbols: TC1,TCI, telomeric repeat binding factor (NIMA-interacting) 1 Gene Symbol: TERF1 Gene Alternate Names: Telomeric repeat binding factor 1,telomeric repeat binding protein 1, Gene Alternate Symbols: PIN2,TRBF1,TRF,TRF1,hTRF1-AS,t-TRF1, testis-specific kinase 1 Gene Symbol: TESK1 TGFB-induced factor (TALE family homeobox) Gene Symbol: TGIF Gene Alternate Names: 5'-TG-3' interacting factor,TALE homeobox TG-interacting factor,homeobox protein TGIF,transforming growth factor-beta-induced factor, Gene Alternate Symbols: HPE4,MGC39747,MGC5066, TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) Gene Symbol: TIMP3 Gene Alternate Names: K222 expressed in degenerative retinas,Tissue inhibitor of metalloproteinase-3,tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory), Gene Alternate Symbols: HSMRK222,K222,K222TA2,SFD, G protein-coupled receptor 137B Gene Symbol: GPR137B Gene Alternate Names: transmembrane 7 superfamily member 1 (upregulated in,transmembrane 7 superfamily member 1 (upregulated in kidney), Gene Alternate Symbols: TM7SF1, transmembrane 9 superfamily member 2 Gene Symbol: TM9SF2 Gene Alternate Names: 76 kDa membrane protein,transmembrane protein 9 superfamily member 2, Gene Alternate Symbols: FLJ26287,MGC117391,P76, transducer of ERBB2, 2 Gene Symbol: TOB2 Gene Alternate Symbols: KIAA1663,TOB4,TOBL,TROB2,Tob2,bK223H9,bK223H9.1.mRNA, topoisomerase (DNA) II beta 180kDa Gene Symbol: TOpmidB Gene Alternate Names: DNA topoisomerase II, 180 kD,topo II beta,topoisomerase (DNA) II beta (180kD), Gene Alternate Symbols: TOPIIB,topmidbeta, tumor protein p53 (Li-Fraumeni syndrome) Gene Symbol: TP53 Gene Alternate Names: P53,p53 tumor suppressor, Gene Alternate Symbols: Cys51Stop,LFS1,P53,TRP53,p53, tumor protein, translationally-controlled 1 Gene Symbol: TPT1 Gene Alternate Names: fortilin,histamine-releasing factor, Gene Alternate Symbols: FLJ27337,HRF,TCTP,fortilin,p02, T cell receptor alpha locus Gene Symbol: TRA@ Gene Alternate Names: T-cell antigen receptor, alpha polypeptide,T-cell receptor, alpha (V,D,J,C), Gene Alternate Symbols: FLJ22602,MGC117436,MGC22624,MGC23964,MGC71411,TCRA,TCRD,TRA,TRDD3, T cell receptor beta locus Gene Symbol: TRB@ Gene Alternate Names: T-cell antigen receptor, beta polypeptide,T-cell receptor, beta cluster, Gene Alternate Symbols: TCRB,TRB, X-ray repair complementing defective repair in Chinese hamster cells 1 Gene Symbol: XRCC1 Gene Alternate Names: DNA repair protein XRCC1,X-ray-repair, complementing defective, repair in Chinese hamster, Gene Alternate Symbols: RCC, tubulin, alpha 1 (testis specific) Gene Symbol: TUBA1 Gene Alternate Names: testis-specific alpha tubulin,tubulin alpha-1 chain, Gene Alternate Symbols: FLJ30169,H2-ALPHA, TXK tyrosine kinase Gene Symbol: TXK Gene Alternate Names: PTK4 protein tyrosine kinase,PTK4 protein tyrosine kinase 4, Gene Alternate Symbols: BTKL,MGC22473,PSCTK5,PTK4,RLK,TKL, TYRO protein tyrosine kinase binding protein Gene Symbol: TYROBP Gene Alternate Symbols: DApgkb2,KARAP,PLO-SL,PLOSL, UDP glucuronosyltransferase 1 family, polypeptide A cluster Gene Symbol: UGT1A@ Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A cluster,UGT, Gene Alternate Symbols: GNT1,UGT,UGT1,UGT1A,UGT1A1, UDP glucuronosyltransferase 1 family, polypeptide A10 Gene Symbol: UGT1A10 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A10,UDP-glucuronosyltransferase 1A10, Gene Alternate Symbols: UDPGT,UGT1J, UDP glucuronosyltransferase 1 family, polypeptide A3 Gene Symbol: UGT1A3 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A3, Gene Alternate Symbols: UGT1*3,UGT1C, UDP glucuronosyltransferase 1 family, polypeptide A4 Gene Symbol: UGT1A4 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A4, Gene Alternate Symbols: HUG-BR2,UDPGT,UGT1*4,UGT1D, UDP glucuronosyltransferase 1 family, polypeptide A5 Gene Symbol: UGT1A5 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A5, Gene Alternate Symbols: UDPGT,UGT1*5,UGT1E, UDP glucuronosyltransferase 1 family, polypeptide A6 Gene Symbol: UGT1A6 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A6, Gene Alternate Symbols: GNT1,HLUGP,HLUGpgkb,MGC29860,UDPGT,UGT1,UGT1*6,UGT1F, UDP glucuronosyltransferase 1 family, polypeptide A7 Gene Symbol: UGT1A7 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A6,UDP glycosyltransferase 1 family, polypeptide A7,UDP-glucuronosyltransferase 1A7, Gene Alternate Symbols: UDPGT,UGT1*7,UGT1G, UDP glucuronosyltransferase 1 family, polypeptide A8 Gene Symbol: UGT1A8 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A8, Gene Alternate Symbols: UDPGT,UGT1H, UDP glucuronosyltransferase 2 family, polypeptide B15 Gene Symbol: UGT2B15 Gene Alternate Names: UDP glycosyltransferase 2 family, polypeptide B15,UDP-glucuronyltransferase, family 2, beta-15, Gene Alternate Symbols: UGT2B8, vitamin D (1,25- dihydroxyvitamin D3) receptor Gene Symbol: VDR Gene Alternate Names: NR1I1,vitamin D receptor, Gene Alternate Symbols: NR1I1, vascular endothelial growth factor Gene Symbol: VEGFA Gene Alternate Symbols: MGC70609,VEGFA,VPF, vascular endothelial growth factor B Gene Symbol: VEGFB Gene Alternate Symbols: VEGFL,VRF, von Willebrand factor Gene Symbol: VWF Gene Alternate Names: Coagulation factor VIII VWF (von Willebrand factor), Gene Alternate Symbols: F8VWF,VWD, xanthine dehydrogenase Gene Symbol: XDH Gene Alternate Names: dehydrogenase,xanthene dehydrogenase,xanthine oxidase,xanthine oxidoreductase, Gene Alternate Symbols: XO,XOR, X-ray repair complementing defective repair in Chinese hamster cells 4 Gene Symbol: XRCC4 Gene Alternate Names: DNA repair protein XRCC4,X-ray repair, complementing defective, repair in Chinese hamster, YY1 transcription factor Gene Symbol: YY1 Gene Alternate Symbols: DELTA,NF-E1,UCRBP,YIN-YANG-1, zinc finger protein 157 (HZF22) Gene Symbol: ZNF157 Gene Alternate Symbols: HZF22, ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Gene Symbol: ABCC3 Gene Alternate Names: ABC31,ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 3; ABCC3,CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER2; CMOAT2,EST90757,MLpmid,MOAT-D,MRP3,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; MRP3,cMOAT2,canicular multispecific organic anion transporter,multidrug resistance associated protein, Gene Alternate Symbols: ABC31,ABCC3,AF085690.1,CMOAT2,EST90757,MLpmid,MOAT-D,MRP3,cMOAT2, carboxylesterase 2 (intestine, liver) Gene Symbol: CES2 Gene Alternate Names: CE-2,iCE,intestinal carboxylesterase,intestinal carboxylesterase; liver carboxylesterase-2,liver carboxylesterase-2, Gene Alternate Symbols: CE-2,ICE,iCE, zinc finger protein, subfamily 1A, 1 (Ikaros) Gene Symbol: IKZF1 Gene Alternate Names: CLL-associated antigen KW-6,Ikaros (zinc finger protein), Gene Alternate Symbols: Hs.54452,IK1,IKAROS,LYF1,LyF-1,PRO0758,ZNFN1A1,hIk-1, zinc finger protein, subfamily 1A, 3 (Aiolos) Gene Symbol: IKZF3 Gene Alternate Symbols: AIOLOS,ZNFN1A3, WD repeat domain 7 Gene Symbol: WDR7 Gene Alternate Names: TGF-beta resistance associated gene,rabconnectin-3 beta, Gene Alternate Symbols: KIAA0541,TRAG, nuclear receptor subfamily 1, group I, member 2 Gene Symbol: NR1I2 Gene Alternate Names: BXR,ONR1,PAR2,PXR,SXR,steroid and xenobiotic receptor, Gene Alternate Symbols: BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR, leukocyte specific transcript 1 Gene Symbol: LST1 Gene Alternate Names: B144 protein,DNA segment on chromosome 6 (unique) 49 expressed sequence, NK cell triggering receptor, p30,Leukocyte-specific transcript 1,leucocyte specific transcript 1,lymphocyte antigen 117, Gene Alternate Symbols: B144,D6S49E,LST-1,MGC119006,MGC119007, SET and MYND domain containing 3 Gene Symbol: SMYD3 Gene Alternate Names: hypothetical protein FLJ21080,zinc finger protein, subfamily 3A (MYND domain containing), 1,zinc finger, MYND domain containing 1, Gene Alternate Symbols: FLJ21080,MGC104324,ZMYND1,ZNFN3A1,bA74pgkb4.1, adrenergic, beta-1-, receptor Gene Symbol: ADRB1 Gene Alternate Symbols: ADRB1R,B1AR,BETA1AR,RHR, solute carrier family 22 (organic anion/cation transporter), member 9 Gene Symbol: SLC22A9 Gene Alternate Names: organic anion transporter 4, Gene Alternate Symbols: FLJ23666,HOAT4,OAT4,UST3,UST3H,ust3, serine peptidase inhibitor, Kazal type 4 Gene Symbol: SPINK4 Gene Alternate Names: gastrointestinal peptide,serine protease inhibitor, Kazal type 4, Gene Alternate Symbols: MGC133107,PEC-60, THO complex 5 Gene Symbol: THOC5 Gene Alternate Names: chromosome 22 open reading frame 19,gene from NF2/meningioma region of 22q12, Gene Alternate Symbols: C22orf19,Fmip,KIAA0983,PK1.3, serine/threonine kinase 38 Gene Symbol: STK38 Gene Alternate Names: serine threonine protein kinase, Gene Alternate Symbols: NDR,NDR1, WNT inhibitory factor 1 Gene Symbol: WIF1 Gene Alternate Names: Wnt inhibitory factor-1, Gene Alternate Symbols: WIF-1, solute carrier family 22 (organic anion/cation transporter), member 11 Gene Symbol: SLC22A11 Gene Alternate Names: MGC34282,OAT4,hOAT4,organic anion transporter 4, Gene Alternate Symbols: MGC34282,OAT4,SLC22A11,hOAT4, hypermethylated in cancer 2 Gene Symbol: HIC2 Gene Alternate Names: (Hic2),HIC1-related gene on chromosome 22,KIAA1020 protein,cancer,hypermethylated,likely ortholog of mouse hypermethylated in cancer 2 (Hic2), Gene Alternate Symbols: HRG22,KIAA1020,ZBTB30, suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) Gene Symbol: ST18 Gene Alternate Names: KIAA0535,KIAA0535 gene product,zinc finger protein 387, Gene Alternate Symbols: KIAA0535,ZNF387, solute carrier family 22 (organic anion transporter), member 6 Gene Symbol: SLC22A6 Gene Alternate Names: HOAT1,MGC45260,OAT1,OAT1, PAHT, ROAT1,PAHT,ROAT1,SOLUTE CARRIER FAMILY 22, MEMBER 6; SLC22A6,para-aminohippurate transporter,renal organic anion transporter 1, Gene Alternate Symbols: AF097490.1,HOAT1,MGC45260,OAT1,PAHT,ROAT1,SLC22A6, solute carrier family 22 (organic anion transporter), member 8 Gene Symbol: SLC22A8 Gene Alternate Names: MGC24086,OAT3,SOLUTE CARRIER FAMILY 22, MEMBER 8; SLC22A8,organic anion transporter 3, Gene Alternate Symbols: MGC24086,NM_004254.2,OAT3,SLC22A8, adrenergic, beta-2-, receptor, surface Gene Symbol: ADRB2 Gene Alternate Names: ADRBR,B2AR,BAR,beta-2 adrenergic receptor,beta-2 adrenoceptor,catecholamine receptor, Gene Alternate Symbols: ADRB2R,ADRBR,B2AR,BAR,BETA2AR, ATP-binding cassette, sub-family G (WHITE), member 2 Gene Symbol: ABCG2 Gene Alternate Names: ABC transporter,ABC15,ABCP,ATP-BINDING CASSETTE TRANSPORTER, PLACENTA-SPECIFIC; ABCP,ATP-BINDING CASSETTE, SUBFAMILY G, MEMBER 2; ABCG2,ATP-binding cassette sub-family G (WHITE) member 2,ATP-binding cassette transporter G2,BCRP,BCRpgkb,BMDP,BREAST CANCER RESISTANCE PROTEIN; BCRP,CDw338,EST157481,MGC102821,MRX,MXR,MXR1,breast cancer resistance protein,mitoxantrone resistance protein,placenta specific MDR protein, Gene Alternate Symbols: ABC15,ABCG2,ABCP,AF103796.1,BCRP,BCRpgkb,BMDP,CDw338,EST157481,MGC102821,MRX,MXR,MXR1, ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Gene Symbol: ABCC5 Gene Alternate Names: ABC33,ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 5; ABCC5,DKFZp686C1782,EST277145,MOAT-C,MOATC,MRP5,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5; MRP5,SMRP,canalicular multispecific organic anion transporter C,pABC11, Gene Alternate Symbols: ABC33,ABCC5,AF104942.1,DKFZp686C1782,EST277145,MOAT-C,MOATC,MRP5,SMRP,pABC11, ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Gene Symbol: ABCC4 Gene Alternate Names: ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 4; ABCC4,ATP-binding cassette, sub-family C (CFTR\/MRP), member 4,EST170205,MOAT-B,MOATB,MRP4,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4; MRP4,MULTISPECIFIC ORGANIC ANION TRANSPORTER B; CMOATB,bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4),canalicular multispecific organic anion transporter (ABC superfamily), Gene Alternate Symbols: ABCC4,AF071202.1,EST170205,MOAT-B,MOATB,MRP4, adrenergic, beta, receptor kinase 1 Gene Symbol: ADRBK1 Gene Alternate Names: BARK1,GRK2, Gene Alternate Symbols: BARK1,BETA-ARK1,GRK2, adrenergic, beta, receptor kinase 2 Gene Symbol: ADRBK2 Gene Alternate Names: BARK2,GRK3, Gene Alternate Symbols: BARK2,GRK3, sulfotransferase family 4A, member 1 Gene Symbol: SULT4A1 Gene Alternate Names: OTTHUMP00000028875,SULTX3,brain sulphotransferase-like,hBR-STL-1,nervous system cytosolic sulfotransferase,sulfortranferase family 4A, member 1,sulfotransferase-related protein, Gene Alternate Symbols: BR-STL-1,BRSTL1,DJ388M5.3,MGC40032,NST,SULTX3,hBR-STL-1, sulfotransferase family, cytosolic, 1C, member 2 Gene Symbol: SULT1C2 Gene Alternate Names: SULT1C sulfotransferase,sulfotransferase 1C2,sulfotransferase family, cytosolic, 1C, member C2, Gene Alternate Symbols: MGC34422,SULT1C, sulfotransferase family, cytosolic, 1B, member 1 Gene Symbol: SULT1B1 Gene Alternate Names: ST1B2,sulfotransferase 1B1,sulfotransferase 1B2,thyroid hormone sulfotransferase, Gene Alternate Symbols: MGC13356,ST1B2,SULT1B2, UDP glucuronosyltransferase 1 family, polypeptide A9 Gene Symbol: UGT1A9 Gene Alternate Names: UDP glycosyltransferase 1 family, polypeptide A9, Gene Alternate Symbols: HLUGP4,LUGP4,UDPGT,UGT1AI, UDP glucuronosyltransferase 1 family, polypeptide A1 Gene Symbol: UGT1A1 Gene Alternate Names: UDP glucuronosyltransferase 1A1,UDP glycosyltransferase 1 family, polypeptide A1,UGT1A,bilirubin UDP-glucuronosyltransferase 1-1,bilirubin UDP-glucuronosyltransferase isozyme 1, Gene Alternate Symbols: GNT1,HUG-BR1,UDPGT,UGT1,UGT1*1,UGT1A,UGT1A5, resistin Gene Symbol: RETN Gene Alternate Names: found in inflammatory zone 3, Gene Alternate Symbols: ADSF,FIZZ3,MGC126603,MGC126609,RETN1,RSTN,XCpgkb, gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) Gene Symbol: GGH Gene Alternate Names: conjugase,folylpolygammaglutamyl hydrolase, Gene Alternate Symbols: GH, tumor necrosis factor (ligand) superfamily, member 13b Gene Symbol: TNFSF13B Gene Alternate Names: ApoL related ligand TALL-1,B-cell activating factor,B-lymphocyte stimulator,DTL precursor,TNF and ApoL-related leukocyte expressed ligand 1,TNF homolog that activates apoptosis,delta BAFF,dendritic cell-derived TNF-like molecule,tumor necrosis factor (ligand) superfamily, member 20,tumor necrosis factor-like protein ZTNF4, Gene Alternate Symbols: BAFF,BLYS,CD257,TALL-1,TALL1,THANK,TNFSF20,ZTNF4, tumor necrosis factor (TNF superfamily, member 2) Gene Symbol: TNF Gene Alternate Names: APC1 protein,TNF superfamily, member 2,TNF, macrophage-derived,TNF, monocyte-derived,tumor necrosis factor,tumor necrosis factor (cachectin),tumor necrosis factor, alpha (cachectin), Gene Alternate Symbols: CACHECTIN,DIF,TNF-alpha,TNFA,TNFSF2, Acquired Immunodeficiency Syndrome Disease Alternate Names: AIDS,Acquired Immune Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndrome, Acquired,Immunodeficiency Syndromes, Acquired,Immunologic Deficiency Syndrome, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency, Adenocarcinoma Disease Alternate Names: Adenocarcinoma, Basal Cell,Adenocarcinoma, Granular Cell,Adenocarcinoma, Oxyphilic,Adenocarcinoma, Tubular,Adenocarcinomas,Adenocarcinomas, Basal Cell,Adenocarcinomas, Granular Cell,Adenocarcinomas, Oxyphilic,Adenocarcinomas, Tubular,Adenoma, Malignant,Adenomas, Malignant,Basal Cell Adenocarcinoma,Basal Cell Adenocarcinomas,Carcinoma, Cribriform,Carcinoma, Granular Cell,Carcinoma, Tubular,Carcinomas, Cribriform,Carcinomas, Granular Cell,Carcinomas, Tubular,Cribriform Carcinoma,Cribriform Carcinomas,Granular Cell Adenocarcinoma,Granular Cell Adenocarcinomas,Granular Cell Carcinoma,Granular Cell Carcinomas,Malignant Adenoma,Malignant Adenomas,Oxyphilic Adenocarcinoma,Oxyphilic Adenocarcinomas,Tubular Adenocarcinoma,Tubular Adenocarcinomas,Tubular Carcinoma,Tubular Carcinomas, Adenoma Disease Alternate Names: Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas, Alcoholism Disease Alternate Names: Abuse, Alcohol,Alcohol Abuse,Alcoholic Intoxication, Chronic,Chronic Alcoholic Intoxication,Intoxication, Chronic Alcoholic, Alzheimer dl:Disease Disease Alternate Names: Acute Confusional Senile Dementia,Alzheimer Dementia, Presenile,Alzheimer dl:Disease, Early Onset,Alzheimer dl:Disease, Late Onset,Alzheimer Type Dementia,Alzheimer Type Senile Dementia,Alzheimer's dl:Disease,Alzheimer's dl:Disease, Focal Onset,Dementia, Alzheimer Type,Dementia, Presenile,Dementia, Presenile Alzheimer,Dementia, Primary Senile Degenerative,Dementia, Senile,Dementias, Presenile,Dementias, Senile,dl:Disease, Alzheimer,dl:Disease, Alzheimer's,Early Onset Alzheimer dl:Disease,Focal Onset Alzheimer's dl:Disease,Late Onset Alzheimer dl:Disease,Presenile Alzheimer Dementia,Presenile Dementia,Presenile Dementias,Primary Senile Degerative Dementia,Senile Dementia,Senile Dementia, Acute Confusional,Senile Dementia, Alzheimer Type,Senile Dementias, Amenorrhea Disease Alternate Names: Amenorrhea, Postpartum,Postpartum Amenorrhea,Postpartum Amenorrheas, Amyloidosis Disease Alternate Names: Amyloidoses, Anemia, Aplastic Disease Alternate Names: Anemia, Hypoplastic,Anemias, Aplastic,Anemias, Hypoplastic,Aplastic Anemia,Aplastic Anemias,Hypoplastic Anemia,Hypoplastic Anemias, Anemia, Megaloblastic Disease Alternate Names: Anemias, Megaloblastic,Megaloblastic Anemia,Megaloblastic Anemias, Angina Pectoris Disease Alternate Names: Angor Pectoris,Stenocardia,Stenocardias, Angioneurotic Edema Disease Alternate Names: Angioedema,Angioedemas,Angioneurotic Edemas,Edema, Angioneurotic,Edema, Quincke's,Edemas, Angioneurotic,Giant Urticaria,Giant Urticarias,Quincke Edema,Quincke's Edema,Quinckes Edema,Urticaria, Giant,Urticarias, Giant, Arteriosclerosis Disease Alternate Names: Arterial Fatty Streak,Arterial Fatty Streaks,Arterioloscleroses,Arteriolosclerosis,Arterioscleroses,Atheroma,Atheromas,Atheroscleroses,Atherosclerosis,Calcific Scleroses, Medial,Calcific Sclerosis, Medial,Fatty Streak, Arterial,Fatty Streaks, Arterial,Medial Calcific Scleroses,Medial Calcific Sclerosis,Monkeberg Medial Calcific Sclerosis,Monkeberg's Medial Calcific Sclerosis,Scleroses, Medial Calcific,Sclerosis, Medial Calcific,Streak, Arterial Fatty,Streaks, Arterial Fatty, Arthritis Disease Alternate Names: Arthritides,Polyarthritides,Polyarthritis, Arthritis, Experimental Disease Alternate Names: Adjuvant Arthritis,Arthritides, Collagen,Arthritis, Adjuvant,Arthritis, Adjuvant-Induced,Arthritis, Collagen,Arthritis, Collagen-Induced,Collagen Arthritides,Collagen Arthritis,Collagen-Induced Arthritides,Collagen-Induced Arthritis, Arthritis, Rheumatoid Disease Alternate Names: Rheumatoid Arthritis, Asthma Disease Alternate Names: Asthma, dlnchial,Asthmas,Asthmas, dlnchial,dlnchial Asthma,dlnchial Asthmas, Autoimmune dl:Diseases Disease Alternate Names: Autoimmune dl:Disease,dl:Disease, Autoimmune,dl:Diseases, Autoimmune, Basal Cell Nevus Syndrome Disease Alternate Names: Gorlin Syndrome,Nevoid Basal Cell Carcinoma Syndrome,Nevus Syndrome, Basal Cell,Syndrome, Gorlin, Bladder Neoplasms Disease Alternate Names: Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Bladder Tumors,Cancer of Bladder,Cancer of the Bladder,Cancer, Bladder,Cancers, Bladder,Neoplasm, Bladder,Neoplasms, Bladder,Tumor, Bladder,Tumors, Bladder, Blood Coagulation Disorders Disease Alternate Names: Blood Coagulation Disorder,Coagulation Disorder, Blood,Coagulation Disorders, Blood,Disorder, Blood Coagulation,Disorders, Blood Coagulation, Bone Resorption Disease Alternate Names: Bone Loss, Osteoclastic,Bone Losses, Osteoclastic,Bone Resorptions,Loss, Osteoclastic Bone,Losses, Osteoclastic Bone,Osteoclastic Bone Loss,Osteoclastic Bone Losses,Resorption, Bone,Resorptions, Bone, Bradycardia Disease Alternate Names: Bradyarrhythmia,Bradyarrhythmias,Bradycardias, Brain Neoplasms Disease Alternate Names: Benign Brain Neoplasm,Benign Brain Neoplasms,Benign Neoplasm, Brain,Benign Neoplasms, Brain,Brain Benign Neoplasm,Brain Benign Neoplasms,Brain Cancer,Brain Cancers,Brain Malignant Neoplasm,Brain Malignant Neoplasms,Brain Neoplasm,Brain Neoplasm, Benign,Brain Neoplasm, Malignant,Brain Neoplasm, Primary,Brain Neoplasms, Benign,Brain Neoplasms, Malignant,Brain Neoplasms, Malignant, Primary,Brain Neoplasms, Primary,Brain Neoplasms, Primary Malignant,Brain Tumor,Brain Tumor, Primary,Brain Tumor, Recurrent,Brain Tumors,Brain Tumors, Primary,Brain Tumors, Recurrent,Cancer of Brain,Cancer of the Brain,Cancer, Brain,Cancers, Brain,Intracranial Neoplasm,Intracranial Neoplasms,Malignant Brain Neoplasm,Malignant Brain Neoplasms,Malignant Neoplasm, Brain,Malignant Neoplasms, Brain,Malignant Primary Brain Neoplasms,Malignant Primary Brain Tumors,Neoplasm, Brain,Neoplasm, Intracranial,Neoplasms, Brain,Neoplasms, Brain, Benign,Neoplasms, Brain, Malignant,Neoplasms, Brain, Primary,Neoplasms, Intracranial,Primary Brain Neoplasm,Primary Brain Neoplasms,Primary Brain Tumor,Primary Brain Tumors,Primary Malignant Brain Neoplasms,Primary Malignant Brain Tumors,Recurrent Brain Tumor,Recurrent Brain Tumors,Tumor, Brain,Tumors, Brain, Breast Neoplasms Disease Alternate Names: Breast Cancer,Breast Cancers,Breast Neoplasm,Cancer of Breast,Cancer of the Breast,Cancer, Breast,Cancers, Breast,Neoplasm, Breast,Neoplasms, Breast, Carcinoma, Renal Cell Disease Alternate Names: Adenocarcinoma, Renal Cell,Adenocarcinomas, Renal Cell,Carcinoma, Hypernephroid,Carcinoma, Nephroid,Carcinomas, Hypernephroid,Carcinomas, Nephroid,Carcinomas, Renal Cell,Grawitz Tumor,Hypernephroid Carcinoma,Hypernephroid Carcinomas,Hypernephroma,Hypernephromas,Nephroid Carcinoma,Nephroid Carcinomas,Renal Cell Adenocarcinoma,Renal Cell Adenocarcinomas,Renal Cell Carcinoma,Renal Cell Carcinomas,Tumor, Grawitz, Carcinoma, Squamous Cell Disease Alternate Names: Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinoma,Squamous Cell Carcinomas, Cardiovascular dl:Diseases Disease Alternate Names: Cardiovascular dl:Disease,dl:Disease, Cardiovascular,dl:Diseases, Cardiovascular, Carotid Artery dl:Diseases Disease Alternate Names: Arterial dl:Disease, Carotid,Arterial dl:Diseases, Carotid,Arterial dl:Diseases, Common Carotid,Arterial dl:Diseases, External Carotid,Arterial dl:Diseases, Internal Carotid,Artery dl:Disease, Carotid,Artery dl:Diseases, Carotid,Artery Disorder, Carotid,Artery Disorders, Carotid,Atherosclerotic dl:Disease, Carotid,Atherosclerotic dl:Diseases, Carotid,Carotid Arterial dl:Disease,Carotid Arterial dl:Diseases,Carotid Artery dl:Disease,Carotid Artery Disorder,Carotid Artery Disorders,Carotid Atheroscleroses,Carotid Atherosclerosis,Carotid Atherosclerotic dl:Disease,Carotid Atherosclerotic dl:Diseases,Common Carotid Artery dl:Diseases,Disorders, Carotid Artery,External Carotid Artery dl:Diseases,Internal Carotid Artery dl:Diseases, Ischemic Attack, Transient Disease Alternate Names: Anterior Circulation Transient Ischemic Attack,Attack, Transient Ischemic,Attacks, Transient Ischemic,Brain Stem Ischemia, Transient,Brain Stem Transient Ischemic Attack,Brain TIA,Brainstem Ischemia, Transient,Brainstem Ischemias, Transient,Brainstem Transient Ischemic Attack,Carotid Circulation Transient Ischemic Attack,Cerebral Ischemia, Transient,Cerebral Ischemias, Transient,Crescendo Transient Ischemic Attacks,Ischemia, Transient Brainstem,Ischemia, Transient Cerebral,Ischemias, Transient Brainstem,Ischemias, Transient Cerebral,Ischemic Attacks, Transient,Posterior Circulation Transient Ischemic Attack,TIA (Transient Ischemic Attack),TIA, Brain,TIAs (Transient Ischemic Attack),Transient Brainstem Ischemia,Transient Cerebral Ischemia,Transient Cerebral Ischemias,Transient Ischemic Attack,Transient Ischemic Attack, Anterior Circulation,Transient Ischemic Attack, Brain Stem,Transient Ischemic Attack, Brainstem,Transient Ischemic Attack, Carotid Circulation,Transient Ischemic Attack, Posterior Circulation,Transient Ischemic Attack, Vertedlbasilar Circulation,Transient Ischemic Attacks,Transient Ischemic Attacks, Crescendo,Vertedlbasilar Circulation Transient Ischemic Attack, Colitis, Ulcerative Disease Alternate Names: Colitides, Ulcerative,Hemorrhagic Proctocolitides,Hemorrhagic Proctocolitis,Hemorrhagic Rectocolitides,Hemorrhagic Rectocolitis,Proctocolitides, Hemorrhagic,Proctocolitides, Ulcerative,Proctocolitis, Hemorrhagic,Proctocolitis, Ulcerative,Rectocolitides, Hemorrhagic,Rectocolitides, Ulcerative,Rectocolitis, Hemorrhagic,Rectocolitis, Ulcerative,Ulcerative Colitides,Ulcerative Colitis,Ulcerative Proctocolitides,Ulcerative Proctocolitis,Ulcerative Rectocolitides,Ulcerative Rectocolitis, Colonic Neoplasms Disease Alternate Names: Cancer of Colon,Cancer of the Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Cancer,Colon Cancers,Colon Neoplasm,Colon Neoplasms,Colonic Cancer,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon,Neoplasms, Colonic, Coronary Arteriosclerosis Disease Alternate Names: Arterioscleroses, Coronary,Arteriosclerosis, Coronary,Artery dl:Disease, Coronary,Artery dl:Diseases, Coronary,Atheroscleroses, Coronary,Atherosclerosis, Coronary,Coronary Arterioscleroses,Coronary Artery dl:Disease,Coronary Artery dl:Diseases,Coronary Atheroscleroses,Coronary Atherosclerosis,dl:Disease, Coronary Artery,dl:Diseases, Coronary Artery, Coronary dl:Disease Disease Alternate Names: Coronary dl:Diseases,Coronary Heart dl:Disease,Coronary Heart dl:Diseases,Coronary Occlusion,Coronary Occlusions,dl:Disease, Coronary,dl:Disease, Coronary Heart,dl:Diseases, Coronary,dl:Diseases, Coronary Heart,Heart dl:Disease, Coronary,Heart dl:Diseases, Coronary,Occlusion, Coronary,Occlusions, Coronary, Crohn dl:Disease Disease Alternate Names: Colitis, Granulomatous,Crohn's dl:Disease,Crohns dl:Disease,Enteritis, Granulomatous,Enteritis, Regional,Ileitis, Regional,Ileitis, Terminal,Ileocolitis, Cushing Syndrome Disease Alternate Names: Cushing's Syndrome,Cushings Syndrome,Syndrome, Cushing,Syndrome, Cushing's, Cystic Fidlsis Disease Alternate Names: Cystic Fidlsis, Pancreatic,Fidlcystic dl:Disease of Pancreas,Fidlsis, Cystic,Fidlsis, Pancreatic Cystic,Mucoviscidoses,Mucoviscidosis,Pancreas Fidlcystic dl:Disease,Pancreas Fidlcystic dl:Diseases,Pancreatic Cystic Fidlses,Pancreatic Cystic Fidlsis, Diabetes Mellitus, Insulin-Dependent Disease Alternate Names: Autoimmune Diabetes,Brittle Diabetes Mellitus,Diabetes Mellitus, Brittle,Diabetes Mellitus, Insulin Dependent,Diabetes Mellitus, Juvenile Onset,Diabetes Mellitus, Juvenile-Onset,Diabetes Mellitus, Ketosis Prone,Diabetes Mellitus, Ketosis-Prone,Diabetes Mellitus, Sudden Onset,Diabetes Mellitus, Sudden-Onset,Diabetes Mellitus, Type 1,Diabetes Mellitus, Type I,Diabetes, Autoimmune,IDDM,Insulin-Dependent Diabetes Mellitus,Juvenile-Onset Diabetes Mellitus,Ketosis-Prone Diabetes Mellitus,Mellitus, Sudden-Onset Diabetes,Sudden-Onset Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent Disease Alternate Names: Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Slow Onset,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,Diabetes Mellitus, Type 2,Diabetes Mellitus, Type II,Ketosis-Resistant Diabetes Mellitus,MODY,Maturity Onset Diabetes Mellitus,Maturity-Onset Diabetes Mellitus,NIDDM,Non-Insulin-Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus, Diarrhea Disease Alternate Names: Diarrheas, Emphysema Epilepsy Disease Alternate Names: Aura,Auras,Awakening Epilepsy,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Epilepsy, Cryptogenic,Epileptic Seizure,Epileptic Seizures,Seizure Disorder,Seizure Disorders,Seizure, Epileptic,Seizure, Single,Seizures, Epileptic,Seizures, Single,Single Seizure,Single Seizures, Esophageal Neoplasms Disease Alternate Names: Cancer of Esophagus,Cancer of the Esophagus,Cancer, Esophageal,Cancer, Esophagus,Cancers, Esophageal,Cancers, Esophagus,Esophageal Cancer,Esophageal Cancers,Esophageal Neoplasm,Esophagus Cancer,Esophagus Cancers,Esophagus Neoplasm,Esophagus Neoplasms,Neoplasm, Esophageal,Neoplasm, Esophagus,Neoplasms, Esophageal,Neoplasms, Esophagus, Gastrointestinal Neoplasms Disease Alternate Names: Cancer of Gastrointestinal System,Cancer of the Gastrointestinal System,Cancer, Gastrointestinal,Cancers, Gastrointestinal,Gastrointestinal Cancer,Gastrointestinal Cancers,Gastrointestinal Neoplasm,Gastrointestinal System Cancer,Gastrointestinal System Cancers,Neoplasm, Gastrointestinal,Neoplasms, Gastrointestinal, Gingival Hyperplasia Disease Alternate Names: Gingival Hyperplasias,Hyperplasia, Gingival,Hyperplasias, Gingival, Glomerulonephritis Disease Alternate Names: Bright dl:Disease,dl:Disease, Bright,Glomerulonephritides,Heymann Nephritis,Nephritis, Heymann, Heart dl:Diseases Disease Alternate Names: Cardiac dl:Disease,Cardiac dl:Diseases,dl:Disease, Cardiac,dl:Disease, Heart,dl:Diseases, Cardiac,dl:Diseases, Heart,Heart dl:Disease, Heart Failure, Congestive Disease Alternate Names: Congestive Heart Failure,Decompensation, Heart,Failure, Congestive Heart,Heart Decompensation, Hemorrhage Disease Alternate Names: Bleeding,Hemorrhages, Carcinoma, Hepatocellular Disease Alternate Names: Carcinomas, Hepatocellular,Hepatocellular Carcinoma,Hepatocellular Carcinomas,Hepatoma,Hepatomas, Homocystinuria Disease Alternate Names: Cystathionine beta Synthase Deficiency dl:Disease,Cystathionine beta-Synthase Deficiency dl:Disease,Deficiency dl:Disease, Cystathionine beta Synthase,Deficiency dl:Disease, Cystathionine beta-Synthase, Hyperalgesia Disease Alternate Names: Hyperalgesia, Primary,Hyperalgesia, Secondary,Hyperalgesia, Tactile,Hyperalgesia, Thermal,Hyperalgesias,Hyperalgesias, Primary,Hyperalgesias, Secondary,Hyperalgesias, Tactile,Hyperalgesias, Thermal,Hyperalgesic Sensation,Hyperalgesic Sensations,Primary Hyperalgesia,Primary Hyperalgesias,Secondary Hyperalgesia,Secondary Hyperalgesias,Sensation, Hyperalgesic,Sensations, Hyperalgesic,Tactile Hyperalgesia,Tactile Hyperalgesias,Thermal Hyperalgesia,Thermal Hyperalgesias, Hyperbilirubinemia Disease Alternate Names: Bilirubinemia,Bilirubinemias,Hyperbilirubinemias, Hyperlipidemia Disease Alternate Names: Dyslipidemia,Dyslipidemias,Hyperlipemia,Hyperlipemias,Hyperlipidemias, Hypertension Disease Alternate Names: Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures, Hypotension Disease Alternate Names: Blood Pressure, Low,Blood Pressures, Low,Hypotensions,Low Blood Pressure,Low Blood Pressures, Impotence Disease Alternate Names: Dysfunction, Erectile,Dysfunctions, Erectile,Erectile Dysfunction,Erectile Dysfunctions, Ischemia Disease Alternate Names: Ischemias, Labor, Premature Disease Alternate Names: Birth, Premature,Births, Premature,Premature Birth,Premature Births,Premature Labor, Leukemia Disease Alternate Names: Leukemias, Leukemia, Lymphocytic Disease Alternate Names: Leukemia, Large Granular Lymphocytic,Leukemia, Lymphoblastic,Leukemia, Lymphocytic, Large Granular,Leukemia, Lymphoid,Leukemias, Lymphoblastic,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphoblastic Leukemia,Lymphoblastic Leukemias,Lymphocytic Leukemia,Lymphocytic Leukemias,Lymphoid Leukemia,Lymphoid Leukemias, Leukemia, Myelocytic, Acute Disease Alternate Names: Acute Myeloblastic Leukemia,Acute Myeloblastic Leukemias,Acute Myelocytic Leukemia,Acute Myelocytic Leukemias,Acute Myelogenous Leukemia,Acute Myelogenous Leukemias,Leukemia, Acute Myeloblastic,Leukemia, Acute Myelocytic,Leukemia, Acute Myelogenous,Leukemia, Myeloblastic, Acute,Leukemia, Myelogenous, Acute,Leukemia, Myeloid, Acute, M1,Leukemia, Myeloid, Acute, M2,Leukemias, Acute Myeloblastic,Leukemias, Acute Myelocytic,Leukemias, Acute Myelogenous,Myeloblastic Leukemia, Acute,Myeloblastic Leukemias, Acute,Myelocytic Leukemia, Acute,Myelocytic Leukemias, Acute,Myelogenous Leukemia, Acute,Myelogenous Leukemias, Acute,Myeloid Leukemia, Acute, M1,Myeloid Leukemia, Acute, M2, Leukemia, Myeloid Disease Alternate Names: Granulocytic Leukemia,Granulocytic Leukemias,Leukemia, Granulocytic,Leukemia, Myelocytic,Leukemia, Myelogenous,Leukemias, Granulocytic,Leukemias, Myelocytic,Leukemias, Myelogenous,Leukemias, Myeloid,Myelocytic Leukemia,Myelocytic Leukemias,Myelogenous Leukemia,Myelogenous Leukemias,Myeloid Leukemia,Myeloid Leukemias, Liver dl:Diseases, Alcoholic Disease Alternate Names: Alcoholic Liver dl:Disease,Alcoholic Liver dl:Diseases,Liver dl:Disease, Alcoholic, Lung Neoplasms Disease Alternate Names: Cancer of Lung,Cancer of the Lung,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancer,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Neoplasms, Lung,Neoplasms, Pulmonary,Pulmonary Cancer,Pulmonary Cancers,Pulmonary Neoplasm,Pulmonary Neoplasms, Lymphedema Disease Alternate Names: dl:Disease, Milroy,dl:Disease, Milroy's,Lymphedemas,Milroy dl:Disease,Milroy's dl:Disease,Milroys dl:Disease, Lymphoma Disease Alternate Names: Germinoblastic Sarcoma,Germinoblastic Sarcomas,Germinoblastoma,Germinoblastomas,Lymphoma, Malignant,Lymphomas,Lymphomas, Malignant,Malignant Lymphoma,Malignant Lymphomas,Reticulolymphosarcoma,Reticulolymphosarcomas,Sarcoma, Germinoblastic,Sarcomas, Germinoblastic, Malaria Disease Alternate Names: Infection, Plasmodium,Infections, Plasmodium,Plasmodium Infection,Plasmodium Infections, Marfan Syndrome Disease Alternate Names: Arachnodactylies,Arachnodactyly,Marfan's Syndrome,Marfans Syndrome,Syndrome, Marfan,Syndrome, Marfan's, Melanoma Disease Alternate Names: Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant, Migraine Disease Alternate Names: Abdominal Migraine,Abdominal Migraines,Acute Confusional Migraine,Acute Confusional Migraines,Cervical Migraine Syndrome,Cervical Migraine Syndromes,Complicated Migraine,Complicated Migraines,Headache, Migraine,Headache, Sick,Headaches, Migraine,Headaches, Sick,Hemicrania,Hemicrania Migraine,Hemicrania Migraines,Migraine Headache,Migraine Headaches,Migraine Syndrome, Cervical,Migraine Syndromes, Cervical,Migraine Variant,Migraine Variants,Migraine, Abdominal,Migraine, Acute Confusional,Migraine, Complicated,Migraine, Hemicrania,Migraines,Migraines, Abdominal,Migraines, Acute Confusional,Migraines, Complicated,Migraines, Hemicrania,Sick Headache,Sick Headaches,Status Migrainosus,Variant, Migraine,Variants, Migraine, Muscular dl:Diseases Disease Alternate Names: Muscle Disorder,Muscle Disorders,Muscular dl:Disease,Myopathic Condition,Myopathic Conditions,Myopathies,Myopathy, Myelodysplastic Syndromes Disease Alternate Names: Dysmyelopoietic Syndrome,Dysmyelopoietic Syndromes,Myelodysplastic Syndrome,Syndrome, Dysmyelopoietic,Syndrome, Myelodysplastic,Syndromes, Dysmyelopoietic,Syndromes, Myelodysplastic, Myeloid Metaplasia Disease Alternate Names: Agnogenic Myeloid Metaplasia,Agnogenic Myeloid Metaplasias,Metaplasia, Agnogenic Myeloid,Metaplasia, Myeloid,Metaplasias, Agnogenic Myeloid,Metaplasias, Myeloid,Myeloid Metaplasia, Agnogenic,Myeloid Metaplasias,Myeloid Metaplasias, Agnogenic,Myeloses, Nonleukemic,Myelosis, Nonleukemic,Nonleukemic Myeloses,Nonleukemic Myelosis, Myocardial Infarction Disease Alternate Names: Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarct,Myocardial Infarctions,Myocardial Infarcts, Opioid-Related Disorders Disease Alternate Names: Abuse, Narcotic,Abuses, Narcotic,Addiction, Narcotic,Addiction, Opiate,Dependence, Narcotic,Dependence, Opiate,Disorder, Opioid-Related,Narcotic Abuse,Narcotic Abuses,Narcotic Addiction,Narcotic Dependence,Opiate Addiction,Opiate Dependence, Nasopharyngeal Neoplasms Disease Alternate Names: Cancer of Nasopharynx,Cancer of the Nasopharynx,Cancer, Nasopharyngeal,Cancer, Nasopharynx,Cancers, Nasopharyngeal,Cancers, Nasopharynx,Nasopharyngeal Cancer,Nasopharyngeal Cancers,Nasopharyngeal Neoplasm,Nasopharynx Cancer,Nasopharynx Cancers,Nasopharynx Neoplasm,Nasopharynx Neoplasms,Neoplasm, Nasopharyngeal,Neoplasm, Nasopharynx,Neoplasms, Nasopharyngeal,Neoplasms, Nasopharynx, Neoplasms Disease Alternate Names: Benign Neoplasm,Benign Neoplasms,Cancer,Cancers,Neoplasm,Neoplasm, Benign,Neoplasms, Benign,Tumor,Tumors, Neoplasms, Radiation-Induced Disease Alternate Names: Cancer, Radiation Induced,Cancer, Radiation-Induced,Cancers, Radiation-Induced,Neoplasm, Radiation-Induced,Neoplasms, Radiation Induced,Radiation Induced Cancer,Radiation Induced Neoplasms,Radiation-Induced Cancer,Radiation-Induced Cancers,Radiation-Induced Neoplasm,Radiation-Induced Neoplasms, Neural Tube Defects Disease Alternate Names: Acrania,Acranias,Craniorachischises,Craniorachischisis,Cyst, Neurenteric,Cyst, Neuroenteric,Cysts, Neurenteric,Cysts, Neuroenteric,Defect, Neural Tube,Defects, Neural Tube,Developmental Defects, Neural Tube,Developmental Neural Tube Defects,Diastematomyelia,Diastematomyelias,Exencephalies,Exencephaly,Iniencephalies,Iniencephaly,Myelodysplasia,Myelodysplasia, Spinal Cord,Myelodysplasias,Myelodysplasias, Spinal Cord,Neural Tube Defect,Neural Tube Developmental Defects,Neurenteric Cyst,Neurenteric Cysts,Neuroenteric Cyst,Neuroenteric Cysts,Spinal Cord Myelodysplasia,Spinal Cord Myelodysplasias,Tethered Cord Syndrome,Tethered Cord Syndromes, Neutropenia Disease Alternate Names: Neutropenias, Obesity Osteoporosis Disease Alternate Names: Age Related Osteoporosis,Age-Related Bone Loss,Age-Related Bone Losses,Age-Related Osteoporoses,Age-Related Osteoporosis,Bone Loss, Age Related,Bone Loss, Age-Related,Bone Losses, Age-Related,Osteoporoses,Osteoporoses, Age-Related,Osteoporoses, Senile,Osteoporosis, Age Related,Osteoporosis, Age-Related,Osteoporosis, Post Traumatic,Osteoporosis, Post-Traumatic,Osteoporosis, Senile,Post-Traumatic Osteoporoses,Post-Traumatic Osteoporosis,Senile Osteoporoses,Senile Osteoporosis, Ovarian Neoplasms Disease Alternate Names: Cancer of Ovary,Cancer of the Ovary,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovarian,Neoplasms, Ovary,Ovarian Cancer,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancer,Ovary Cancers,Ovary Neoplasm,Ovary Neoplasms, Pain Disease Alternate Names: Ache,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Suffering, Physical,Sufferings, Physical, Parkinson dl:Disease Disease Alternate Names: Idiopathic Parkinson dl:Disease,Idiopathic Parkinson's dl:Disease,Lewy Body Parkinson dl:Disease,Lewy Body Parkinson's dl:Disease,Paralysis Agitans,Parkinson dl:Disease, Idiopathic,Parkinson's dl:Disease,Parkinson's dl:Disease, Idiopathic,Parkinson's dl:Disease, Lewy Body,Parkinsonism, Primary,Primary Parkinsonism, Peripheral Nervous System dl:Diseases Disease Alternate Names: Nerve dl:Disease, Peripheral,Nerve dl:Diseases, Peripheral,Neuropathy, Peripheral,PNS (Peripheral Nervous System) dl:Diseases,PNS dl:Disease,PNS dl:Diseases,Peripheral Nerve dl:Disease,Peripheral Nerve dl:Diseases,Peripheral Nervous System dl:Disease,Peripheral Nervous System Disorders,Peripheral Neuropathies,Peripheral Neuropathy, Prostatic Neoplasms Disease Alternate Names: Cancer of Prostate,Cancer of the Prostate,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Cancer,Prostate Cancers,Prostate Neoplasm,Prostate Neoplasms,Prostatic Cancer,Prostatic Cancers,Prostatic Neoplasm, Psoriasis Disease Alternate Names: Palmoplantaris Pustulosis,Psoriases,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles, Rectal Neoplasms Disease Alternate Names: Cancer of Rectum,Cancer of the Rectum,Cancer, Rectal,Cancer, Rectum,Cancers, Rectal,Cancers, Rectum,Neoplasm, Rectal,Neoplasm, Rectum,Neoplasms, Rectal,Neoplasms, Rectum,Rectal Cancer,Rectal Cancers,Rectal Neoplasm,Rectum Cancer,Rectum Cancers,Rectum Neoplasm,Rectum Neoplasms, Rhabdomyolysis Disease Alternate Names: Rhabdomyolyses, Rheumatic dl:Diseases Disease Alternate Names: dl:Disease, Rheumatic,dl:Diseases, Rheumatic,Enthesopathies,Enthesopathy,Rheumatic dl:Disease,Rheumatism, Rickets Disease Alternate Names: Rachitides,Rachitis, Osteosarcoma Disease Alternate Names: Osteogenic Sarcoma,Osteogenic Sarcomas,Osteosarcomas,Sarcoma, Osteogenic,Sarcomas, Osteogenic, Stomach Neoplasms Disease Alternate Names: Cancer of Stomach,Cancer of the Stomach,Cancer, Gastric,Cancer, Stomach,Cancers, Gastric,Cancers, Stomach,Gastric Cancer,Gastric Cancers,Gastric Neoplasm,Gastric Neoplasms,Neoplasm, Gastric,Neoplasm, Stomach,Neoplasms, Gastric,Neoplasms, Stomach,Stomach Cancer,Stomach Cancers,Stomach Neoplasm, Thrombosis Disease Alternate Names: Thromboses,Thrombus, Tobacco Use Disorder Disease Alternate Names: Dependence, Nicotine,Dependence, Tobacco,Disorder, Nicotine Use,Disorder, Tobacco Use,Disorder, Tobacco-Use,Nicotine Dependence,Nicotine Use Disorder,Nicotine Use Disorders,Tobacco Dependence,Tobacco Dependences,Tobacco Use Disorders,Tobacco-Use Disorder,Use Disorder, Nicotine, Vomiting disease Alternate Names: Emesis, Xeroderma Pigmentosum Disease Alternate Names: Kaposi disease,Kaposi's disease,Kaposis disease, Colorectal Neoplasms Disease Alternate Names: Cancer, Colorectal,Cancers, Colorectal,Carcinoma, Colorectal,Carcinomas, Colorectal,Colorectal Cancer,Colorectal Cancers,Colorectal Carcinoma,Colorectal Carcinomas,Colorectal Neoplasm,Colorectal Tumor,Colorectal Tumors,Neoplasm, Colorectal,Neoplasms, Colorectal,Tumor, Colorectal,Tumors, Colorectal, Inflammatory Bowel dl:Diseases Disease Alternate Names: Bowel dl:Disease, Inflammatory,Bowel dl:Diseases, Inflammatory,disease, Inflammatory Bowel,dl:Diseases, Inflammatory Bowel,Inflammatory Bowel disease, Myocardial Reperfusion Injury Disease Alternate Names: Injuries, Myocardial Reperfusion,Injury, Myocardial Reperfusion,Myocardial Reperfusion Injuries,Reperfusion Injuries, Myocardial,Reperfusion Injury, Myocardial, Leukemia, Lymphocytic, Acute Disease Alternate Names: Acute Lymphoblastic Leukemia,Acute Lymphoblastic Leukemias,Acute Lymphocytic Leukemia,Acute Lymphocytic Leukemias,Adult Acute Lymphocytic Leukemia,Leukemia, Acute Lymphoblastic,Leukemia, Acute Lymphocytic,Leukemia, Lymphoblastic, Acute,Leukemia, Lymphocytic, Acute, Adult,Leukemias, Acute Lymphoblastic,Leukemias, Acute Lymphocytic,Lymphoblastic Leukemia, Acute,Lymphoblastic Leukemias, Acute,Lymphocytic Leukemia, Acute,Lymphocytic Leukemias, Acute, Leukemia, Lymphocytic, Acute, L1 Disease Alternate Names: ALL, Childhood,Childhood ALL,L1 Lymphocytic Leukemia,L1 Lymphocytic Leukemias,Leukemia, L1 Lymphocytic,Leukemia, Lymphoblastic, Acute, L1,Leukemias, L1 Lymphocytic,Lymphoblastic Leukemia, Acute, Childhood,Lymphoblastic Leukemia, Acute, L1,Lymphocytic Leukemia, L1,Lymphocytic Leukemias, L1, Rett Syndrome Disease Alternate Names: Autism Dementia Ataxia Loss of Purposeful Hand Use Syndrome,Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome,Ceredlatrophic Hyperammonemia,Ceredlatrophic Hyperammonemias,Hyperammonemia, Ceredlatrophic,Hyperammonemias, Ceredlatrophic,Rett Disorder,Rett's Disorder,Rett's Syndrome,Retts Syndrome,Syndrome, Rett,Syndrome, Rett's, HIV Infections Disease Alternate Names: HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III Infections,HTLV-III-LAV Infection,HTLV-III-LAV Infections,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human,T-Lymphotropic Virus Type III Infections, Human, Fatigue Syndrome, Chronic Disease Alternate Names: Chronic Fatigue Disorder,Chronic Fatigue Disorders,Chronic Fatigue Fidlmyalgia Syndrome,Chronic Fatigue Syndrome,Chronic Fatigue Syndromes,Chronic Fatigue and Immune Dysfunction Syndrome,Chronic Fatigue-Fidlmyalgia Syndrome,Chronic Fatigue-Fidlmyalgia Syndromes,Disorders, Chronic Fatigue,Encephalomyelitis, Myalgic,Fatigue Disorder, Chronic,Fatigue Disorders, Chronic,Fatigue Syndrome, Postviral,Fatigue Syndromes, Chronic,Fatigue Syndromes, Postviral,Fatigue-Fidlmyalgia Syndrome, Chronic,Fatigue-Fidlmyalgia Syndromes, Chronic,Infectious Mononucleosis Like Syndrome, Chronic,Infectious Mononucleosis-Like Syndrome, Chronic,Myalgic Encephalomyelitis,Postviral Fatigue Syndrome,Postviral Fatigue Syndromes,Royal Free disease,Syndrome, Chronic Fatigue-Fidlmyalgia,Syndromes, Chronic Fatigue-Fidlmyalgia,Syndromes, Postviral Fatigue, Spina Bifida Cystica Disease Alternate Names: Open Spina Bifida,Spina Bifida Aperta,Spina Bifida Manifesta,Spina Bifida, Open, Neoplasms, Second Primary Disease Alternate Names: Cancer, Second,Cancer, Second Primary,Cancer, Therapy-Associated,Cancer, Therapy-Related,Cancer, Treatment-Associated,Cancer, Treatment-Related,Cancers, Second,Cancers, Second Primary,Cancers, Therapy-Associated,Cancers, Therapy-Related,Cancers, Treatment-Associated,Cancers, Treatment-Related,Malignancies, Second,Malignancy, Second,Metachronous Neoplasm,Metachronous Neoplasms,Metachronous Second Primary Neoplasms,Neoplasm, Metachronous,Neoplasm, Second,Neoplasm, Second Primary,Neoplasm, Therapy-Associated,Neoplasm, Therapy-Related,Neoplasm, Treatment-Associated,Neoplasm, Treatment-Related,Neoplasms, Metachronous,Neoplasms, Metachronous Second Primary,Neoplasms, Second,Neoplasms, Therapy Associated,Neoplasms, Therapy Related,Neoplasms, Therapy-Associated,Neoplasms, Therapy-Related,Neoplasms, Treatment Associated,Neoplasms, Treatment Related,Neoplasms, Treatment-Associated,Neoplasms, Treatment-Related,Second Cancer,Second Cancers,Second Malignancies,Second Malignancy,Second Neoplasm,Second Neoplasms,Second Primary Cancer,Second Primary Cancers,Second Primary Neoplasm,Second Primary Neoplasms,Second Primary Neoplasms, Metachronous,Therapy Associated Cancer,Therapy Associated Neoplasms,Therapy Related Cancer,Therapy Related Neoplasms,Therapy-Associated Cancer,Therapy-Associated Cancers,Therapy-Associated Neoplasm,Therapy-Associated Neoplasms,Therapy-Related Cancer,Therapy-Related Cancers,Therapy-Related Neoplasm,Therapy-Related Neoplasms,Treatment Associated Cancer,Treatment Associated Neoplasms,Treatment Related Cancer,Treatment Related Neoplasms,Treatment-Associated Cancer,Treatment-Associated Cancers,Treatment-Associated Neoplasm,Treatment-Associated Neoplasms,Treatment-Related Cancer,Treatment-Related Cancers,Treatment-Related Neoplasm,Treatment-Related Neoplasms, Death, Sudden, Cardiac Disease Alternate Names: Cardiac Death, Sudden,Cardiac Sudden Death,Death, Cardiac Sudden,Death, Sudden Cardiac,Sudden Cardiac Death,Sudden Death, Cardiac, Chromosome Breakage Disease Alternate Names: Breakage, Chromosome,Breakages, Chromosome,Chromosome Breakages, Hot Flashes Disease Alternate Names: Flashes, Hot, Hepatitis C, Chronic Disease Alternate Names: Chronic Hepatitis C, Alcohol-Related Disorders Disease Alternate Names: Alcohol Related Disorders,Alcohol-Related Disorder,Disorder, Alcohol-Related,Disorders, Alcohol-Related, Hyperhomocysteinemia Disease Alternate Names: Hyperhomocysteinemias, Venous Thrombosis Disease Alternate Names: Deep Vein Thromboses,Deep Vein Thrombosis,Deep Venous Thromboses,Deep Venous Thrombosis,Deep-Vein Thromboses,Deep-Vein Thrombosis,Deep-Venous Thromboses,Deep-Venous Thrombosis,Phlebothromboses,Phlebothrombosis,Thromboses, Deep Vein,Thromboses, Deep Venous,Thromboses, Deep-Vein,Thromboses, Deep-Venous,Thromboses, Venous,Thrombosis, Deep Vein,Thrombosis, Deep Venous,Thrombosis, Deep-Vein,Thrombosis, Deep-Venous,Thrombosis, Venous,Vein Thromboses, Deep,Vein Thrombosis, Deep,Venous Thromboses,Venous Thromboses, Deep,Venous Thrombosis, Deep, Metabolic Syndrome X Disease Alternate Names: Cardiovascular Syndrome, Metabolic,Cardiovascular Syndromes, Metabolic,Insulin Resistance Syndrome X,Metabolic Cardiovascular Syndrome,Metabolic Cardiovascular Syndromes,Reaven Syndrome X,Syndrome X, Insulin Resistance,Syndrome X, Metabolic,Syndrome X, Reaven,Syndrome, Metabolic Cardiovascular,Syndromes, Metabolic Cardiovascular, Anxiety Disorders Depressive Disorder Obsessive-Compulsive Disorder Schizophrenia HIV helicobacter pylori, gastric ulcers Pain, Codeine Dependence Ovarian, Lung, breast cancer epithelial cancers liver transplantation codeine dependence glomerulosclerosis Chron's dl:Disease, hematological cancer heparin-induced thrombocytopenia tardive dyskinesia Depression Gilbert syndrome glomerular dl:Disease visceral obesity essential hypertension ALL (acute lymphoblastic leukemia) Disease Alternate Names: acute lymphoblastic leukemia (organ transplant recipients),childhood acute lymphoblastic leukaemia, affective disorders nondiabetic proteinuric nephropathy venous thromboembolism Acquired Long QT Syndrome (aLQTS) estrogen-dependent carcinogenesis psychosis major depression restenosis acetaminophen DrugGenericNamesAPAP,paracetamol,Drug Trade Names:Abenol,Acephen,Aceta Elixir,Aceta Tablets,Acetaminophen,Acetaminophen And Codeine Phosphate,Acetaminophen And Codeine Phosphate #2,Acetaminophen And Codeine Phosphate #3,Acetaminophen And Codeine Phosphate #4,Acetaminophen And Codeine Phosphate No. 2,Acetaminophen And Codeine Phosphate No. 3,Acetaminophen And Codeine Phosphate No. 4,Acetaminophen And Hydrocodone Bitartrate,Acetaminophen Uniserts,Acetaminophen W/ Codeine,Acetaminophen W/ Codeine #2,Acetaminophen W/ Codeine #4,Acetaminophen W/ Codeine No. 2,Acetaminophen W/ Codeine No. 3,Acetaminophen W/ Codeine Phosphate,Acetaminophen W/ Codeine Phosphate #3,Acetaminophen, Aspirin And Caffeine,Acetaminophen, Aspirin, And Codeine Phosphate,Acetaminophen, Butalbital And Caffeine,Acetaminophen, Butalbital, And Caffeine,Acetaminophen, Butalbital, Caffeine, And Codeine Phosphate,Acetaminophen, Caffeine, And Dihydrocodeine Bitartrate,Actamin,Actamin Extra,Actamin Super,Actimol Chewable Tablets,Actimol Children's Suspension,Actimol Infants' Suspension,Actimol Junior Strength Caplets,Allay,Aminofen,Aminofen Max,Anacin-3,Anacin-3 Extra Strength,Anexsia,Anexsia 10/660,Anexsia 5/325,Anexsia 7.5/325,Anexsia 7.5/650,Anoquan,Apacet Capsules,Apacet Elixir,Apacet Extra Strength Caplets,Apacet Extra Strength Tablets,Apacet Regular Strength Tablets,Apacet, Infants,Apap W/ Codeine Phosphate,Apo-Acetaminophen,Aspirin Free Anacin Maximum Strength Caplets,Aspirin Free Anacin Maximum Strength Gel Caplets,Aspirin Free Anacin Maximum Strength Tablets,Aspirin-Free Excedrin Caplets,Atasol Caplets,Atasol Drops,Atasol Forte Caplets,Atasol Forte Tablets,Atasol Oral Solution,Atasol Tablets,Bancap,Bancap Hc,Banesin,Bayer Select Maximum Strength Headache Pain Relief Formula,Bucet,Butalbital And Acetaminophen,Butalbital, Acetaminophen And Caffeine,Butalbital, Acetaminophen, And Caffeine,Butalbital, Acetaminophen, Caffeine,Butalbital, Apap, And Caffeine,Butalbital; Acetaminophen; And Caffeine With Codeine Phosphate,Butapap,Capital And Codeine,Capital With Codeine,Co-Gesic,Codeine Phosphate And Acetaminophen,Codeine, Aspirin, Apap Formula No. 2,Codeine, Aspirin, Apap Formula No. 3,Codeine, Aspirin, Apap Formula No. 4,Dapa,Dapa X-S,Darvocet,Darvocet-N 100,Darvocet-N 50,Datril Extra-Strength,Dhc Plus,Dolene Ap-65,Drixoral Plus,Duradyne Dhc,Empracet W/ Codeine Phosphate #3,Empracet W/ Codeine Phosphate #4,Esgic,Esgic-Plus,Excedrin (Migraine),Excedrin Caplets,Excedrin Extra Strength Caplets,Exdol,Exdol Strong,Femcet,Feverall Junior Strength,Feverall Sprinkle Caps Junior Strength,Feverall Sprinkle Caps, Children's,Feverall, Children's,Feverall, Infants",Fioricet,Fioricet W/ Codeine,Genapap Children's Elixir,Genapap Children's Tablets,Genapap Extra Strength Caplets,Genapap Extra Strength Tablets,Genapap Regular Strength Tablets,Genapap, Infants,Genebs Extra Strength Caplets,Genebs Regular Strength Tablets,Genebs X-Tra,Hy-Phen,Hydrocet,Hydrocodone Bitartrate And Acetaminophen,Infants' Feverall,Injectapap,Liquiprin Children's Elixir,Liquiprin Infants" Drops,Lorcet-Hd,Lortab,Medigesic Plus,Neopap,Norcet,Norco,Oraphen-PD,Oxycet,Oxycodone 2.5/Apap 500,Oxycodone 5/Apap 500,Oxycodone And Acetaminophen,Panadol,Panadol Extra Strength,Panadol Junior Strength Caplets,Panadol Maximum Strength Caplets,Panadol Maximum Strength Tablets,Panadol, Children's,Panadol, Infants,Papa-Deine #3,Papa-Deine #4,Pentazocine Hcl And Acetaminophen,Percocet,Phenaphen Caplets,Phenaphen W/ Codeine No. 2,Phenaphen W/ Codeine No. 3,Phenaphen W/ Codeine No. 4,Phenaphen-650 W/ Codeine,Phrenilin,Phrenilin Forte,Phrenilin With Caffeine And Codeine,Propacet 100,Propoxyphene Hcl And Acetaminophen,Propoxyphene Napsylate And Acetaminophen,Proval #3,Redutemp,Robigesic,Rounox,Roxicet,Roxicet 5/500,Roxilox,Sedapap,Snaplets-FR,St. Joseph Aspirin-Free Fever Reducer for Children,Suppap-120,Suppap-325,Suppap-650,Synalgos-Dc-A,Talacen,Tapanol Extra Strength Caplets,Tapanol Extra Strength Tablets,Tavist Allergy/Sinus/Headache,Tempra,Tempra Caplets,Tempra Chewable Tablets,Tempra D.S,Tempra Drops,Tempra Syrup,Tempra, Infants,Tencon,Triad,Triaprin,Tycolet,Tylenol,Tylenol Arthritis Extended Relief,Tylenol Caplets,Tylenol Children's Chewable Tablets,Tylenol Children's Elixir,Tylenol Children's Suspension Liquid,Tylenol Drops,Tylenol Elixir,Tylenol Extra Strength Adult Liquid Pain Reliever,Tylenol Extra Strength Caplets,Tylenol Extra Strength Gelcaps,Tylenol Extra Strength Tablets,Tylenol Gelcaps,Tylenol Infants Drops,Tylenol Infants" Suspension Drops,Tylenol Junior Strength Caplets,Tylenol Junior Strength Chewable Tablets,Tylenol Regular Strength Caplets,Tylenol Regular Strength Tablets,Tylenol Tablets,Tylenol W/ Codeine,Tylenol W/ Codeine No. 1,Tylenol W/ Codeine No. 2,Tylenol W/ Codeine No. 3,Tylenol W/ Codeine No. 4,Tylox,Tylox-325,Ultracet,Valorin,Valorin Extra,Vicodin,Vicodin Es,Vicodin Hp,Wygesic, acetylcholine albuterol Drug Trade Names:Airet,Albuterol,Apo-Salvent,Gen-Salbutamol Sterinebs P.F.,Novo-Salmol,Proventil,Proventil HFA,Proventil Repetabs,Ventodisk,Ventolin,Ventolin HFA,Ventolin Nebules,Ventolin Nebules P.F.,Ventolin Rotacaps,Volmax, albuterol sulfate Drug Trade Names:Accuneb,Albuterol Sulfate,Combivent,Duoneb,Proventil,Proventil-Hfa,Ventolin,Ventolin Hfa,Ventolin Rotacaps,Volmax, alcohol Drug Trade Names:Alcohol 10% And Dextrose 5%,Alcohol 5% And Dextrose 5%,Alcohol 5% In D5-W,Alcohol 5% In Dextrose 5%,Alcohol 5% In Dextrose 5% In Water,Avagard, alendronate Drug Trade Names:Fosamax, alprazolam Drug Trade Names:Alprazolam,Alprazolam Intensol,Alti-Alprazolam,Apo-Alpraz,Gen-Alprazolam,Novo-Alprazol,Nu-Alpraz,Xanax,Xanax TS, amiodarone Drug Trade Names:Cordarone,Cordarone I've.,Cordarone Intravenous,pms-Amiodarone, amitriptyline Drug Trade Names:Apo-Amitriptyline,Elavil,Endep,Levate,Novotriptyn, amlodipine Drug Trade Names:Norvasc, arsenic trioxide Drug Trade Names:Trisenox, asparaginase DrugGenericNamescolaspase,Drug Trade Names:Elspar,Kidrolase, aspirin Drug Trade Names:217,217 Strong,8-Hour Bayer,Acetaminophen, Aspirin And Caffeine,Acetaminophen, Aspirin, And Codeine Phosphate,Acuprin 81,Aggrenox,Anacin,Anacin Caplets,Anacin Extra Strength,Anacin Maximum Strength,Anacin Tablets,Antidol,Apo-ASA,Apo-ASEN,Arco Pain Tablet,Arthrisin,Artria S.R,Aspergum,Aspir-Low,Aspirin And Caffeine W/ Butalbital,Aspirin Caplets,Aspirin Children's Tablets,Aspirin Regimen Bayer Adult Low Dose,Aspirin Regimen Bayer Regular Strength Caplets,Aspirin Tablets,Aspirin, Coated,Aspirtab,Aspirtab-Max,Astone,Astrin,Axotal,Azdone,Bayer Children's Aspirin,Bayer Extra Strength Aspirin For Migraine Pain,Butal Compound,Butalbital Aspirin And Caffeine,Butalbital Compound,Butalbital W/ Aspirin & Caffeine,Butalbital, Aspirin & Caffeine,Butalbital, Aspirin And Caffeine,Butalbital, Aspirin, Caffeine, And Codeine Phosphate,C2,Calmine,Carisoprodol And Aspirin,Carisoprodol Compound,Carisoprodol, Aspirin And Codeine Phosphate,Codeine, Aspirin, Apap Formula No. 2,Codeine, Aspirin, Apap Formula No. 3,Codeine, Aspirin, Apap Formula No. 4,Codoxy,Compound 65,Coryphen,Darvon Compound,Darvon Compound-65,Darvon W/ Asa,Darvon-N W/ Asa,Dolomine,Easprin,Ecotrin Caplets,Ecotrin Tablets,Empirin,Entrophen 10 Super Strength Caplets,Entrophen 15 Maximum Strength Tablets,Entrophen Caplets,Entrophen Extra Strength,Entrophen Tablets,Equagesic,Excedrin (Migraine),Extended-release Bayer 8-Hour,Extra Strength Bayer Arthritis Pain Formula Caplets,Extra Strength Bayer Aspirin Caplets,Extra Strength Bayer Aspirin Tablets,Fiorinal,Fiorinal W/Codeine No 3,Gensan,Genuine Bayer Aspirin Caplets,Genuine Bayer Aspirin Tablets,Halfprin,Headache Tablet,Healthprin Adult Low Strength,Healthprin Full Strength,Healthprin Half-Dose,Herbopyrine,Instantine,Invagesic,Invagesic Forte,Kalmex,Lanorinal,Maximum Strength Arthritis Foundation Safety Coated Aspirin,Measurin,Mepro-Aspirin,Meprobamate And Aspirin,Methocarbamol And Aspirin,Micrainin,Nervine,Norgesic,Norgesic Forte,Norwich Aspirin,Novasen,Novasen Sp.C,Orphenadrine Citrate, Aspirin, And Caffeine,Orphengesic,Orphengesic Forte,Oxycodone And Aspirin,Oxycodone And Aspirin (Half-Strength),P-A-C Revised Formula,PMS-ASA,Pain Aid,Percodan,Percodan-Demi,Propoxyphene Compound 65,Propoxyphene Compound-65,Propoxyphene Hcl W/ Aspirin And Caffeine,Q-Gesic,Robaxisal,Roxiprin,Sloprin,Soma Compound,Soma Compound W/ Codeine,St. Joseph Adult Chewable Aspirin,Synalgos-Dc,Talwin Compound,Vicoprin,ZORprin, atenolol Drug Trade Names:Apo-Atenolol,Atenolol,Atenolol And Chlorthalidone,Novo-Atenol,Tenoretic 100,Tenoretic 50,Tenormin, atorvastatin Drug Trade Names:Lipitor, azathioprine Drug Trade Names:Azathioprine,Imuran, budesonide Drug Trade Names:Entocort,Entocort Ec,Pulmicort,Pulmicort Nebuamp,Pulmicort Respules,Pulmicort Turbuhaler,Rhinocort,Rhinocort Aqua,Rhinocort Turbuhaler, bupropion Drug Trade Names:Wellbutrin,Wellbutrin SR,Wellbutrin XL,Zyban, caffeine Drug Trade Names:Acetaminophen, Aspirin And Caffeine,Acetaminophen, Butalbital And Caffeine,Acetaminophen, Butalbital, And Caffeine,Acetaminophen, Butalbital, Caffeine, And Codeine Phosphate,Acetaminophen, Caffeine, And Dihydrocodeine Bitartrate,Anoquan,Aspirin And Caffeine W/ Butalbital,Butal Compound,Butalbital Aspirin And Caffeine,Butalbital Compound,Butalbital W/ Aspirin & Caffeine,Butalbital, Acetaminophen And Caffeine,Butalbital, Acetaminophen, And Caffeine,Butalbital, Acetaminophen, Caffeine,Butalbital, Apap, And Caffeine,Butalbital, Aspirin & Caffeine,Butalbital, Aspirin And Caffeine,Butalbital, Aspirin, Caffeine, And Codeine Phosphate,Butalbital; Acetaminophen; And Caffeine With Codeine Phosphate,Cafergot,Caffedrine Caplets,Compound 65,Darvon Compound,Darvon Compound-65,Dexitac Stay Alert Stimulant,Dhc Plus,Enerjets,Ercatab,Esgic,Esgic-Plus,Excedrin (Migraine),Femcet,Fioricet,Fioricet W/ Codeine,Fiorinal,Fiorinal W/Codeine No 3,Invagesic,Invagesic Forte,Keep Alert,Lanorinal,Maximum Strength SnapBack Stimulant Powders,Medigesic Plus,Migergot,NoDoz Maximum Strength Caplets,Norgesic,Norgesic Forte,Orphenadrine Citrate, Aspirin, And Caffeine,Orphengesic,Orphengesic Forte,Pep-Back,Phrenilin With Caffeine And Codeine,Propoxyphene Compound 65,Propoxyphene Compound-65,Propoxyphene Hcl W/ Aspirin And Caffeine,Quick Pep,Synalgos-Dc,Synalgos-Dc-A,Triad,Ultra Pep-Back,Vivarin,Wake-Up,Wigraine, calcipotriene DrugGenericNamesMC 903,calcipotriol,Drug Trade Names:Dovonex, calcitriol Drug Trade Names:Calcijex,Calcitriol,Rocaltrol, capecitabine Drug Trade Names:Xeloda, captopril Drug Trade Names:Capoten,Capozide 25/15,Capozide 25/25,Capozide 50/15,Capozide 50/25,Captopril,Captopril And Hydrochlorothiazide, carbamazepine Drug Trade Names:Apo-Carbamazepine,Atretol,Carbamazepine,Carbatrol,Epitol,Novo-Carbamaz,Nu-Carbamazepine,Taro-Carbamazepine,Taro-Carbamazepine CR,Tegretol,Tegretol CR,Tegretol Chewtabs,Tegretol-XR,Tegretol-Xr, carboplatin Drug Trade Names:Paraplatin,Paraplatin-AQ, carvedilol Drug Trade Names:Coreg, cefazolin Drug Trade Names:Ancef,Kefzol, celecoxib Drug Trade Names:Celebrex, cerivastatin chlorambucil Drug Trade Names:Leukeran, chlorthalidone Drug Trade Names:Apo-Chlorthalidone,Atenolol And Chlorthalidone,Chlorthalidone,Clonidine Hcl And Chlorthalidone,Clorpres,Combipres,Demi-Regroton,Hygroton,Kerledex,Lopressidone,Novo-Thalidone,Regroton,Tenoretic 100,Tenoretic 50,Thalitone,Uridon, cimetidine Drug Trade Names:Apo-Cimetidine,Cimetidine,Cimetidine Hcl,Gen-Cimetidine,Novo-Cimetine,Nu-Cimet,PMS-Cimetidine,Peptol,Tagamet,Tagamet HB,Tagamet HB 200,Tagamet Hb,Tagamet Hb 200, cisapride cisplatin Drug Trade Names:Cisplatin,Platinol,Platinol-AQ,Platinol-Aq, citalopram Drug Trade Names:Celexa, clomipramine Drug Trade Names:Anafranil, clopidogrel Drug Trade Names:Plavix, clozapine Drug Trade Names:Clozapine,Clozaril, cocaine codeine Drug Trade Names:Paveral, colchicine Drug Trade Names:Col-Probenecid,Colbenemid,Proben-C,Probenecid And Colchicine,Probenecid W/ Colchicine, cyclobenzaprine Drug Trade Names:Flexeril, cyclophosphamide Drug Trade Names:Cyclophosphamide,Cytoxan,Lyophilized Cytoxan,Neosar,Procytox, cyclosporine DrugGenericNamescyclosporin A,Drug Trade Names:Cyclosporine,Neoral,Restasis,Sandimmune,SangCya,Sangcya, cytarabine DrugGenericNamesara-C,cytosine arabinoside,Drug Trade Names:Cytarabine,Cytosar,Cytosar-U,Depocyt, daunorubicin Drug Trade Names:Cerubidine, desipramine Drug Trade Names:Norpramin,Pertofrane, dexamethasone Drug Trade Names:AK-Dex,Aeroseb-Dex,Baldex,Cortastat,Cortastat 10,Cortastat LA,Decaderm,Decadron,Decadron Phosphate,Decaspray,Deronil,Dexacidin,Dexacort Turbinaire,Dexair,Dexamethasone,Dexamethasone Intensol,Dexasone,Dexasone L.A.,Dexasporin,Dexone 0.5,Dexone 0.75,Dexone 1.5,Dexone 4,Dexone LA,Dexotic,Diodex,Hexadrol,Hexadrol Phosphate,Maxidex,Maxitrol,Mymethasone,Neomycin And Polymyxin B Sulfates And Dexamethasone,Ocu-Dex,Oradexon,PMS-Dexamethasone Sodium Phosphate,R.O.-Dexasone,Solurex,Solurex LA,Spersadex,Storz-Dexa,Tobradex,Tobramycin And Dexamethasone, dextromethorphan Drug Trade Names:Balminil DM,Balminil DM Children,Benylin Adult Formula Cough Suppressant,Benylin DM,Benylin DM 12 Hour,Benylin DM For Children 12 Hour,Benylin DM for children,Benylin Pediatric Cough Suppressant,dlncho-Grippol-DM,Calmylin #1,Cough-X,Creo-Terpin,Delsym,Delsym Cough Formula,Diabe-TUSS DM Syrup,Hold DM,Koffex DM,Novahistex DM,Novahistine DM,Pertussin CS Children's Strength,Pertussin DM Extra Strength,Robitussin Maximum Strength Cough Suppressant,Robitussin Pediatric,Robitussin Pediatric Cough Suppressant,Sucrets 4 Hour Cough Suppressant,Triaminic DM Long Lasting For Children,Trocal,Vicks 44 Cough Relief, diclofenac Drug Trade Names:Apo-Diclo,Cataflam,Novo-Difenac,Novo-Difenac SR,Nu-Diclo,Solaraze,Voltaren,Voltaren Ophtha,Voltaren Ophthalmic,Voltaren Rapide,Voltaren SR, digoxin Drug Trade Names:Digoxin,Digoxin Pediatric,Lanoxicaps,Lanoxin,Lanoxin Elixir Pediatric,Lanoxin Injection,Lanoxin Injection Pediatric,Lanoxin Pediatric,Lanoxin Pediatric Elixir,Lanoxin Pediatric Injection,Novo-Digoxin, diltiazem Drug Trade Names:Apo-Diltiaz,Cardizem,Cardizem CD,Cardizem SR,Dilacor-XR,Novo-Diltazem,Nu-Diltiaz,Syn-Diltiazem, docetaxel Drug Trade Names:Taxotere, doxazosin Drug Trade Names:Cardura,Cardura-1,Cardura-2,Cardura-4, doxepin Drug Trade Names:Novo-Doxepin,Sinequan,Triadapin,Zonalon, doxorubicin Drug Trade Names:Adriamycin PFS,Adriamycin RDF,Rubex, efavirenz DrugGenericNamesEFV,Drug Trade Names:Sustiva, enalapril Drug Trade Names:Vasotec, enalaprilat Drug Trade Names:Enalaprilat,Vasotec, epinephrine Drug Trade Names:Adrenalin,Adrenalin Chloride,Alphacaine Hcl W/ Epinephrine,Ana-Guard,AsthmaNefrin,Asthmahaler Mist,dlnkaid Mist,dlnkaid Suspension Mist,Bupivacaine Hcl And Epinephrine,Duranest,Epi E Z Pen Jr,EpiPen,EpiPen Auto-Injector,EpiPen Jr.,EpiPen Jr. Auto-Injector,Epifrin,Epinephrine,Epipen,Epipen E Z Pen,Epipen Jr.,Glaucon,Iontocaine,Lidocaine Hcl And Epinephrine,Lidocaine Hcl W/ Epinephrine,Lidocaton,Nephron,Octocaine,Primatene Mist,Procaine Hcl W/ Epinephrine,S-2,Septocaine,Sus-Phrine Sulfite-Free,Vaponefrin,Xylocaine W/ Epinephrine,adrenaline,microNefrin, estradiol Drug Trade Names:Activelle,Alora,Climara,Clinagen LA 40,Combipatch,Delestrogen,Depo-Estradiol,Depogen,Esclim,Estrace,Estraderm,Estradiol,Estradot,Estragyn LA 5,Estrasorb,Estring,Estro-L.A.,Fempatch,Gynodiol,Innofem,Menaval-20,Ortho-Prefest,Vagifem,Valergen-20,Valergen-40,Vivelle,Vivelle-Dot, estrogens DrugGenericNamesDES,Dienoestrol,Fosfestrol,Oestradiol,Oestrone,Piperazine Estrone Sulfate,Stilboestrol, etoposide DrugGenericNamesVP-16,Drug Trade Names:Etopophos,Etoposide,Toposar,VePesid,Vepesid, fentanyl Drug Trade Names:Actiq,Duragesic,Sublimaze, fexofenadine Drug Trade Names:Allegra, flecainide Drug Trade Names:Tambocor, fluorouracil DrugGenericNames5-FU,Drug Trade Names:Adrucil,Carac,Efudex,Fluoroplex,Fluorouracil, fluoxetine DrugGenericNamesfluoxetine hcl,fluoxetine hydrochloride,Drug Trade Names:Prozac,Prozac Weekly,Sarafem, fluticasone Drug Trade Names:Cutivate,Flonase,Flovent,Flovent Diskus,Flovent Rotadisk, fluvastatin Drug Trade Names:Lescol, fluvoxamine Drug Trade Names:Luvox, folic acid DrugGenericNamesVitamin B 9,Drug Trade Names:Apo-Folic,Berocca Pn,Cernevit-12,Folic Acid,Folicet,Folvite,Folvron,Infuvite Pediatric,M.V.C. 9+3,M.V.I. Pediatric,M.V.I.-12,M.V.I.-12 Lyophilized,Multi-12,Mvc Plus,Novo-Folacid,Vitaped, fosinopril Drug Trade Names:Monopril, gemcitabine Drug Trade Names:Gemzar, gemfidlzil Drug Trade Names:Apo-Gemfidlzil,Gemfidlzil,Gen-Fidl,Lopid,Novo-Gemfidlzil,Nu-Gemfidlzil, glyburide Drug Trade Names:Albert Glyburide,Apo-Glyburide,DiaBeta,Diabeta,Euglucon,Gen-Glybe,Glucovance,Glyburide,Glyburide (Micronized),Glynase,Glynase PresTab,Med Glybe,Micronase,Novo-Glyburide,Nu-Glyburide, granisetron Drug Trade Names:Kytril, haloperidol Drug Trade Names:Apo-Haloperidol,Haldol,Haldol Decanoate,Haldol LA,Haldol Solutab,Haloperidol,Novo-Peridol,PMS Haloperidol,Peridol, heparin Drug Trade Names:Calcilean,Calciparine,Hepalean,Heparin Leo,Liquaemin, hesperidin hydrochlorothiazide Drug Trade Names:Accuretic,Aldactazide,Aldoril 15,Aldoril 25,Aldoril D30,Aldoril D50,Amiloride Hcl And Hydrochlorothiazide,Apo-Hydro,Apresazide,Apresoline-Esidrix,Atacand Hct,Avalide,Bisoprolol Fumarate And Hydrochlorothiazide,Cam-Ap-Es,Capozide 25/15,Capozide 25/25,Capozide 50/15,Capozide 50/25,Captopril And Hydrochlorothiazide,Diovan Hct,Diuchlor H,Dyazide,Enalapril Maleate And Hydrochlorothiazide,Esidrix,Esimil,H.R.-50,Hydra-Zide,Hydralazine And Hydrochlorthiazide,Hydralazine Hcl And Hydrochlorothiazide,Hydralazine Hcl W/ Hydrochlorothiazide 100/50,Hydralazine Hcl W/ Hydrochlorothiazide 25/25,Hydralazine Hcl W/ Hydrochlorothiazide 50/50,Hydralazine Hcl, Hydrochlorothiazide And Reserpine,Hydralazine Hcl-Hydrochlorothiazide-Reserpine,Hydralazine, Hydrochlorothiazide W/ Reserpine,Hydrap-Es,Hydro-D,Hydro-Reserp,Hydro-Ride,Hydro-Serp "25",Hydro-Serp "50",Hydro-chlor,HydroDIURIL,Hydrochlorothiazide,Hydrochlorothiazide Intensol,Hydrochlorothiazide W/ Hydralazine,Hydrochlorothiazide W/ Reserpine,Hydrochlorothiazide W/ Reserpine And Hydralazine,Hydrodiuril,Hydropres 25,Hydropres 50,Hydroserpine Plus (R-H-H),Hyzaar,Inderide La 120/50,Inderide La 160/50,Inderide La 80/50,Inderide-40/25,Inderide-80/25,Lopressor Hct,Lotensin Hct,Maxzide,Maxzide-25,Methyldopa And Hydrochlorothiazide,Micardis Hct,Microzide,Moduretic 5-50,Monopril-Hct,Neo-Codema,Normozide,Novo-Hydrazide,Oretic,Oreticyl 25,Oreticyl 50,Oreticyl Forte,Prinzide,Propranolol Hcl & Hydrochlorothiazide,Propranolol Hcl And Hydrochlorothiazide,Reserpine And Hydrochlorothiazide,Reserpine And Hydrochlorothiazide-50,Reserpine, Hydralazine Hcl And Hydrochlorothiazide,Reserpine, Hydrochlorothiazide, And Hydralazine Hcl,Ser-A-Gen,Ser-Ap-Es,Serpasil-Esidrix #1,Serpasil-Esidrix #2,Spironolactone + Hydrochlorothiazide,Spironolactone And Hydrochlorothiazide,Spironolactone W/ Hydrochlorothiazide,Spironolactone/Hydrochlorothiazide,Teveten Hct,Timolide 10-25,Trandate Hct,Triamterene And Hydrochlorothiazide,Unipres,Uniretic,Urozide,Vaseretic,Viskazide,Zestoretic,Ziac,Zide, imipramine Drug Trade Names:Apo-Imipramine,Impril,Norfranil,Novopramine,Tipramine,Tofranil,Tofranil-PM, indinavir DrugGenericNamesIDV,Drug Trade Names:Crixivan, irinotecan DrugGenericNames7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin,CPT-11,irinotecan hydrochloride,Drug Trade Names:Camptosar, isoproterenol Drug Trade Names:Isuprel,Isuprel Mistometer,Medihaler-Iso, itraconazole Drug Trade Names:Sporanox, ketoconazole Drug Trade Names:Ketoconazole,Nizoral,Nizoral A-D,Nizoral A-D Shampoo,Nizoral Cream,Nizoral Shampoo, leucovorin DrugGenericNamescitrovorum factor,folinic acid,Drug Trade Names:Wellcovorin, lidocaine Drug Trade Names:After Burn Double Strength Gel,After Burn Double Strength Spray,After Burn Gel,After Burn Spray,Alphacaine,Anestacon Jelly,Dalcaine,DermaFlex,Dilocaine,Emla,L-Caine,Lanabiotic,Lidocaine,Lidoderm,Lidoject-1,Lidoject-2,Norwood Sunburn Spray,Octocaine,Octocaine-100,Octocaine-50,Rocephin Kit,Xylocaine,Xylocaine 5% Spinal,Xylocaine Dental Ointment,Xylocaine Endotracheal,Xylocaine Test Dose,Xylocaine Viscous,Xylocaine-MPF,Xylocaine-MPF with Glucose,Xylocard,Zilactin-L, lisinopril Drug Trade Names:Prinivil,Prinzide,Zestoretic,Zestril, lopinavir Drug Trade Names:Kaletra, losartan DrugGenericNamesDuP 753,MK594,Drug Trade Names:Cozaar, lovastatin Drug Trade Names:Advicor,Altoprev,Lovastatin,Mevacor, maprotiline Drug Trade Names:Ludiomil, mefloquine Drug Trade Names:Lariam, mephenytoin Drug Trade Names:Mesantoin, mercaptopurine DrugGenericNames6-MP,Drug Trade Names:Purinethol, metaproterenol Drug Trade Names:Alupent,Arm-a-Med Metaproterenol,Dey-Lute Metaproterenol, metformin Drug Trade Names:Apo-Metformin,Gen-Metformin,Glucophage,Glucophage XR,Glycon,Novo-Metformin,Nu-Metformin, methadone Drug Trade Names:Dolophine,Methadose, methotrexate DrugGenericNamesamethopterin,Drug Trade Names:Folex,Folex PFS,Methotrexate LPF,Rheumatrex, metoprolol Drug Trade Names:Apo-Metoprolol,Apo-Metoprolol (Type L),Betaloc,Betaloc Durules,Lopresor,Lopresor SR,Lopressor,Novometoprol,Nu-Metop,Toprol-XL, mexiletine Drug Trade Names:Mexitil, mibefradil midazolam Drug Trade Names:Versed, mitoxantrone Drug Trade Names:Novantrone, modafinil Drug Trade Names:Provigil, montelukast Drug Trade Names:Singulair, morphine Drug Trade Names:AVINZA,Astramorph PF,Duramorph,Epimorph,Kadian,M S Contin,M-Eslon,M.O.S,M.O.S.-S.R,MS IR,MS.IR,MS/L,MS/L Concentrate,MS/S,MSIR,Morphine Extra-Forte,Morphine Forte,Morphine H.P,Morphitec,OMS Concentrate,Oramorph SR,RMS Uniserts,Rescudose,Roxanol,Roxanol 100,Roxanol UD,Statex,Statex Drops, mycophenolate mofetil Drug Trade Names:Cellcept, naproxen Drug Trade Names:Aleve,Anaprox,Anaprox DS,Apo-Napro-Na,Apo-Napro-Na DS,Apo-Naproxen,EC-Naprosyn,Ec-Naprosyn,Naprelan,Naprosyn,Naprosyn-E,Naprosyn-SR,Naproxen,Naxen,Novo-Naprox,Novo-Naprox Sodium,Novo-Naprox Sodium DS,Nu-Naprox,Synflex,Synflex DS, nelfinavir DrugGenericNamesNFV,Drug Trade Names:Viracept, nevirapine DrugGenericNamesNVP,Drug Trade Names:Viramune, nicotine Drug Trade Names:Commit,Habitrol,NicoDerm CQ,Nicoderm,Nicoderm Cq,Nicorette,Nicorette Plus,Nicotine,Nicotrol,Nicotrol Inhaler,Nicotrol NS,Prostep, nifedipine Drug Trade Names:Adalat,Adalat CC,Adalat Cc,Adalat PA,Adalat XL,Apo-Nifed,Nifedipine,Novo-Nifedin,Nu-Nifed,Procardia,Procardia XL,Procardia Xl, nitric oxide DrugGenericNamesMononitrogen Monoxide,Nitrogen Monoxide,Drug Trade Names:INOmax,Inomax, nitroglycerin Drug Trade Names:Deponit,Glyceryl Trinitrate,Minitran,Nitro Iv,Nitro-Bid,Nitro-Bid IV,Nitro-Dur,Nitro-par,Nitro-time,Nitrocot,Nitrodisc,Nitrogard,Nitroglycerin,Nitroglycerin In Dextrose 5%,Nitroglyn E-R,Nitroject,Nitrol,Nitrolingual,Nitrolingual Pumpspray,Nitronal,Nitrong SR,Nitrostat,Transderm-Nitro,Tridil, nortriptyline Drug Trade Names:Aventyl,Pamelor, olanzapine Drug Trade Names:Zyprexa,Zyprexa Intramuscular,Zyprexa Zydis, omeprazole Drug Trade Names:Losec,Omeprazole,Prilosec,Zegerid, ondansetron Drug Trade Names:Zofran,Zofran ODT,Zofran Odt, paclitaxel Drug Trade Names:Paclitaxel,Taxol, paroxetine Drug Trade Names:Paxil,Paxil CR, perphenazine Drug Trade Names:Apo-Perphenazine,Etrafon 2-10,Etrafon 2-25,Etrafon-A,Etrafon-Forte,PMS Perphenazine,Perphenazine,Perphenazine And Amitriptyline Hcl,Triavil 2-10,Triavil 2-25,Triavil 4-10,Triavil 4-25,Triavil 4-50,Trilafon,Trilafon Concentrate, phenobarbital Drug Trade Names:Ancalixir,Barbita,Luminal,Solfoton, phenylephrine Drug Trade Names:Ak-Dilate,Ak-Nefrin,Alconefrin Nasal Drops 12,Alconefrin Nasal Drops 25,Alconefrin Nasal Drops 50,Alconefrin Nasal Spray 25,Dilatair,Dionephrine,Doktors,Duration,I-Phrine,Isopto Frin,Minims Phenylephrine,Mydfrin,Neo-Synephrine,Neo-Synephrine Nasal Drops,Neo-Synephrine Nasal Jelly,Neo-Synephrine Nasal Spray,Neo-Synephrine Pediatric Nasal Drops,Neofrin,Nostril Spray Pump,Nostril Spray Pump Mild,Ocu-Phrin Sterile Eye Drops,Ocu-Phrin Sterile Ophthalmic Solution,Ocugestrin,Phenoptic,Prefrin Liquifilm,Relief Eye Drops for Red Eyes,Rhinall,Rhinall-10 Children's Flavored Nose Drops,Spersaphrine,Vicks Sinex, phenytoin Drug Trade Names:Dilantin,Dilantin Infatabs,Dilantin Kapseals,Dilantin-125,Dilantin-30,Phentytoin,Phenytek,Phenytoin, pravastatin Drug Trade Names:Pravachol, prednisone Drug Trade Names:Apo-Prednisone,Cordrol,Cortan,Delta-Dome,Deltasone,Fernisone,Liquid Pred,Meticorten,Orasone,Orasone 1,Orasone 10,Orasone 20,Orasone 5,Orasone 50,Paracort,Pred-Pak 45,Pred-Pak 79,Predisone Intensol,Prednicen-M,Prednicot,Prednisone,Prednisone Intensol,Servisone,Sterapred,Sterapred DS,Winpred, propafenone Drug Trade Names:Rythmol,Rythmol SR, propranolol Drug Trade Names:Apo-Propranolol,Detensol,Inderal,Inderal LA,Novopranol,pms Propranolol, repaglinide Drug Trade Names:Prandin, ribavirin DrugGenericNamestribavirin,Drug Trade Names:Copegus,Rebetol,Virazole, rifampin Drug Trade Names:Rifadin,Rifadin IV,Rifamate,Rifampin,Rifater,Rimactane,Rofact, riluzole Drug Trade Names:Rilutek, risperidone Drug Trade Names:Risperdal,Risperdal M-Tab, ritonavir Drug Trade Names:Kaletra,Norvir,Norvir SEC, ropivacaine Drug Trade Names:Naropin, salmeterol Drug Trade Names:Serevent,Serevent Diskhaler,Serevent Diskus, saquinavir DrugGenericNamesSQV,Drug Trade Names:Fortovase,Invirase, sertraline Drug Trade Names:Zoloft, sildenafil Drug Trade Names:Viagra, simvastatin Drug Trade Names:Zocor, sirolimus DrugGenericNamesRapamycin,Drug Trade Names:Rapamune, sulfasalazine DrugGenericNamessalicylazosulfapyridine,Drug Trade Names:Alti-Sulfasalazine,Alti-Sulfasalazine (Enteric-Coated),Azulfidine,Azulfidine EN-Tabs,Azulfidine En-Tabs,PMS-Sulfasalazine,PMS-Sulfasalazine E.C.,S.A.S. Enteric-500,S.A.S.-500,Salazopyrin,Salazopyrin EN-Tabs,Sulfasalazine, tacrine DrugGenericNamesTHA,tetrahydroaminoacridine,Drug Trade Names:Cognex, tacrolimus DrugGenericNamesAnother commonly used name is FK 506,Drug Trade Names:Prograf,Protopic, tamoxifen Drug Trade Names:Apo-Tamox,Gen-Tamoxifen,Nolvadex,Nolvadex-D,Novo-Tamoxifen,PMS-Tamoxifen,Tamofen,Tamone, teniposide DrugGenericNamesVM-26,Drug Trade Names:Vumon, terbutaline Drug Trade Names:Brethaire,Brethine,Bricanyl,Bricanyl Turbuhaler, testosterone Drug Trade Names:Andriol,Andro L.A. 200,AndroGel,Androderm,Androgel,Andronate 100,Andronate 200,Andropository 200,Andryl 200,Delatest,Delatestryl,Depo-Testosterone,Depo-Testosterone Cypionate,Depotest,Everone 200,Malogen in Oil,Scheinpharm Testone-Cyp,Striant,T-Cypionate,Testamone 100,Testaqua,Testex,Testoderm,Testoderm TTS,Testoderm Tts,Testoderm with Adhesives,Testopel Pellets,Testosterone,Testred Cypionate 200,Testrin-P.A,Virilon IM, theophylline Drug Trade Names:Accurdln,Aerolate,Aerolate Iii,Aerolate Jr,Aerolate Sr,Apo-Theo LA,Aquaphyllin,Asmalix,dlnkodyl,Dicurin Procaine,Duraphyl,Elixicon,Elixomin,Elixophyllin,Elixophyllin Sr,Labid,Lanophyllin,Mersalyl-Theophylline,PMS Theophylline,Pulmophylline,Quidln-T,Quidln-T Dividose,Quidln-T/SR Dividose,Quidln-T/Sr,Respbid,Slo-Bid,Slo-Bid Gyrocaps,Slo-Phyllin,Somophyllin-Crt,Somophyllin-T,Sustaire,T-Phyl,Theo-24,Theo-Dur,Theo-SR,Theo-Time,Theo-X,Theobid,Theobid Duracaps,Theobid Jr.,Theochron,Theoclear L.A.-130,Theoclear L.A.-260,Theoclear-100,Theoclear-200,Theoclear-80,Theolair,Theolair SR,Theolair-SR,Theolair-Sr,Theolixir,Theophyl,Theophyl-225,Theophyl-Sr,Theophylline,Theophylline 0.04% And Dextrose 5% In Plastic Container,Theophylline 0.08% And Dextrose 5% In Plastic Container,Theophylline 0.16% And Dextrose 5% In Plastic Container,Theophylline 0.2% And Dextrose 5% In Plastic Container,Theophylline 0.32% And Dextrose 5% In Plastic Container,Theophylline 0.4% And Dextrose 5% In Plastic Container,Theophylline And Dextrose 5% In Plastic Container,Theophylline In Dextrose 5% In Plastic Container,Theophylline-Sr,Theovent,Theovent Long-Acting,Truxophyllin,Uni-Dur,Uniphyl, thioguanine Drug Trade Names:Lanvis,Tabloid,Thioguanine, thioridazine Drug Trade Names:Apo-Thioridazine,Mellaril,Mellaril Concentrate,Mellaril-S,Novo-Ridazine,PMS Thioridazine, thiotepa Drug Trade Names:Thioplex,Thiotepa, ticlopidine Drug Trade Names:Ticlid, timolol Drug Trade Names:Apo-Timol,Apo-Timop,Betimol,Blocadren,Novo-Timol,Tim-AK,Timoptic,Timoptic in Ocudose,Timoptic-XE, tolbutamide Drug Trade Names:Apo-Tolbutamide,Novo-Butamide,Orinase,Tolbutamide, topotecan Drug Trade Names:Hycamtin, tramadol Drug Trade Names:Ultram, tranylcypromine Drug Trade Names:Parnate, trazodone Drug Trade Names:Desyrel, venlafaxine Drug Trade Names:Effexor,Effexor XR, verapamil Drug Trade Names:Apo-Verap,Calan,Calan SR,Isoptin,Isoptin SR,Novo-Veramil,Nu-Verap,Verelan, vinblastine Drug Trade Names:Velban,Velbe, vincristine Drug Trade Names:Oncovin,Vincasar PFS, vitamin b12 vitamin b6 vitamin d warfarin Drug Trade Names:Coumadin,Warfilone, yohimbine Drug Trade Names:Actibine,Aphrodyne,Baron-X,Dayto Himbin,PMS-Yohimbine,Prohim,Thybine,Yocon,Yohimar,Yohimex,Yoman,Yovital, zolmitriptan Drug Trade Names:Zomig,Zomig-ZMT,Zomig-Zmt, 6-mercaptopurine ethanol benzene interferon alpha antihistamines antidepressants antipsychotics ace inhibitors glucocorticoids prostaglandins xenobiotics cationic xenobiotics zoxazolamine aflatoxin b1 sparteine epipodophyllotoxin vinyl chloride debrisoquine neuroleptics heroin antineoplastic agents antimetabolite salbutamol nucleosides zuclopenthixol thiopurines 6-thioguanine arsenite imidapril topoisomerase ii inhibitors apolipoprotein E Gene Symbol: APOE Gene Alternate Symbols: AD2,MGC1571,apoprotein, ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Gene Symbol: ABCC6 Gene Alternate Names: ANTHRACYCLINE RESISTANCE-ASSOCIATED PROTEIN; ARA,ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 6; ABCC6,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 6; MRP6,anthracycline resistance-associated,pseudoxanthoma elasticum, Gene Alternate Symbols: ABC34,AF076622.1,ARA,EST349056,MLpgkb,MOATE,MRP6,PXE,PXE1, arrestin, beta 1 Gene Symbol: ARRB1 Gene Alternate Symbols: ARB1,ARR1, arrestin, beta 2 Gene Symbol: ARRB2 Gene Alternate Symbols: ARB2,ARR2,DKFZp686L0365, ataxia telangiectasia mutated (includes complementation groups A, C and D) Gene Symbol: ATM Gene Alternate Names: AT complementation group A,AT complementation group C,AT complementation group D,AT complementation group E,AT mutated,AT protein,human phosphatidylinositol 3-kinase homolog,serine-protein kinase ATM, Gene Alternate Symbols: AT1,ATA,ATC,ATD,ATDC,ATE,DKFZp781A0353,MGC74674,TEL1, ATPase, Na+/K+ transporting, alpha 1 polypeptide Gene Symbol: ATpgkbA1 Gene Alternate Names: ATPase, Na+K+ transporting, alpha-1 polypeptide, Gene Alternate Symbols: MGC3285,MGC51750, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) Gene Symbol: EGFR Gene Alternate Names: Epidermal growth factor receptor,avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog),truncated epidermal growth factor receptor, Gene Alternate Symbols: ERBB,ERBB1,mENA, calcium channel, voltage-dependent, L type, alpha 1C subunit Gene Symbol: CACNA1C Gene Alternate Symbols: CACH2,CACN2,CACNL1A1,CCHL1A1,CaV1.2,TS, calcium channel, voltage-dependent, L type, alpha 1D subunit Gene Symbol: CACNA1D Gene Alternate Names: calcium channel, L type, alpha-1 polypeptide, isoform 2,calcium channel, neuroendocrine/brain-type, alpha 1 subunit,voltage-gated calcium channel alpha 1 subunit,voltage-gated calcium channel alpha subunit Cav1.3, Gene Alternate Symbols: CACH3,CACN4,CACNL1A2,CCHL1A2, cytidine deaminase Gene Symbol: CDA Gene Alternate Names: CDD,small cytidine deaminase, Gene Alternate Symbols: CDD,hscd, cell division cycle 2, G1 to S and G2 to M Gene Symbol: CDC2 Gene Alternate Names: cell cycle controller CDC2,cell division control protein 2 homolog,cyclin-dependent kinase 1,p34 protein kinase, Gene Alternate Symbols: CDK1,DKFZp686L20222,MGC111195, ABCC2_101530945_T T 98.99 ABCC2_101530945_C C 1.01 101530945 ABCC2_101531029_G G 99.8 ABCC2_101531029_A A 0.2 101531029 ABCC2_101531043_G G 59.31 ABCC2_101531043_A A 40.69 101531043 ABCC2_101531300_A A 99.39 ABCC2_101531300_G G 0.61 101531300 ABCC2_101531353_G G 98.38 ABCC2_101531353_A A 1.62 101531353 ABCC2_101531527_C C 99.6 ABCC2_101531527_A A 0.4 101531527 ABCC2_101531533_C C 99.8 ABCC2_101531533_GC GC 0.2 101531533 ABCC2_101531569_G G 84.62 ABCC2_101531569_A A 15.38 101531569 ABCC2_101531573_A A 63.97 ABCC2_101531573_G G 36.03 101531573 ABCC2_101531794_C C 99.8 ABCC2_101531794_A A 0.2 101531794 ABCC2_101531859_G G 99.8 ABCC2_101531859_A A 0.2 101531859 ABCC2_101532568_C C 86.62 ABCC2_101532568_T T 13.38 101532568 ABCC2_101532569_G G 99.6 ABCC2_101532569_A A 0.4 101532569 NANOGP6_101542143_C C 99.6 NANOGP6_101542143_G G 0.4 101542143 NANOGP6_101544140_G G 98.58 NANOGP6_101544140_A A 1.42 101544140 NANOGP6_101546814_G G 99.19 NANOGP6_101546814_T T 0.81 101546814 NANOGP6_101549084_A A 99.56 NANOGP6_101549084_G G 0.44 101549084 NR3C1_142638349_T T 50.1 NR3C1_142638349_G G 49.9 142638349 NR3C1_142639459_A A 98.6 NR3C1_142639459_G G 1.4 142639459 T 100 142640422 ADRB2_148186541_T T 67.4 ADRB2_148186541_C C 32.6 148186541 ADRB2_148186568_T T 66.79 ADRB2_148186568_C C 33.21 148186568 ADRB2_148187855_CCCCCCCCCCCCC CCCCCCCCCCCCC 45.15 ADRB2_148187855_CCCCCCCCCCC CCCCCCCCCCC 28.64 ADRB2_148187855_CCCCCCCCCCCC CCCCCCCCCCCC 17.54 148187855 ADRB2_148188207_C C 99.15 ADRB2_148188207_T T 0.85 148188207 SLC22A1_160550040_G G 99.55 SLC22A1_160550040_A A 0.45 160550040 ABCB1_86778189_T T 96.91 ABCB1_86778189_C C 3.09 86778189 ABCB1_86874152_G G 97.17 ABCB1_86874152_A A 2.83 86874152 ABCB1_86874758_A A 98.76 ABCB1_86874758_G G 1.24 86874758 ABCB1_86874844_T T 94.97 ABCB1_86874844_C C 5.03 86874844 GGH_64090300_A A 83.33 GGH_64090300_G G 16.67 64090300 ABCC2_101534347_G 99.19 G ABCC2_101534347_A 0.81 A 101534347 NANOGP6_101546947_A 99.85 A NANOGP6_101546947_C 0.15 C 101546947 ABCC2_101555104_T 99.58 T ABCC2_101555104_G 0.42 G 101555104 ABCC2_101558003_C 95.95 C ABCC2_101558003_G 4.05 G 101558003 ABCC2_101559987_T 97.98 T ABCC2_101559987_C 2.02 C 101559987 ABCC2_101567267_G 99.8 G ABCC2_101567267_T 0.2 T 101567267 ABCC2_101580209_C 99.78 C ABCC2_101580209_A 0.22 A 101580209 ABCC2_101580372_C 99.59 C ABCC2_101580372_T 0.41 T 101580372 ABCC2_101580450_T 99.79 T ABCC2_101580450_G 0.21 G 101580450 ABCC2_101585805_G 99.6 G ABCC2_101585805_A 0.4 A 101585805 ABCC2_101586043_G 99.8 G ABCC2_101586043_C 0.2 C 101586043 ABCC2_101591694_C 99.39 C ABCC2_101591694_T 0.61 T 101591694 ABCC2_101591870_G 99.8 G ABCC2_101591870_A 0.2 A 101591870 ABCC2_101593512_T 82.23 T ABCC2_101593512_C 17.77 C 101593512 ABCC2_101594233_C 99.35 C ABCC2_101594233_T 0.65 T 101594233 ABCC2_101595540_G 94.13 G ABCC2_101595540_C 5.87 C 101595540 ABCC2_101596673_G 92.06 G ABCC2_101596673_A 7.94 A 101596673 ABCC2_101596885_A 99.79 A ABCC2_101596885_C 0.21 C 101596885 ABCC2_101600555_G 93.9 G ABCC2_101600555_A 6.1 A 101600555 VDR_46526102_G 66.72 G VDR_46526102_A 33.28 A 46526102 MTHFR_11785269_C 84.17 C MTHFR_11785269_G 15.83 G 11785269 MTHFR_11785483_G 99.79 G MTHFR_11785483_C 0.21 C 11785483 MTHFR_11786566_G 81.88 G MTHFR_11786566_A 18.12 A 11786566 MTHFR_11786782_G 97.5 G MTHFR_11786782_A 2.5 A 11786782 MTHFR_11788937_G 82.71 G MTHFR_11788937_T 17.29 T 11788937 MTHFR_11789021_T 65.62 T MTHFR_11789021_C 34.38 C 11789021 CLCN6_11790644_G 68.92 G CLCN6_11790644_A 31.08 A 11790644 CLCN6_11794721_C 97.92 C CLCN6_11794721_T 2.08 T 11794721 CLCN6_11794724_C 92.92 C CLCN6_11794724_T 7.08 T 11794724 CLCN6_11794731_C 96.88 C CLCN6_11794731_G 3.12 G 11794731 CLCN6_11795542_C 99.79 C CLCN6_11795542_T 0.21 T 11795542 CLCN6_11797201_T 99.58 T CLCN6_11797201_C 0.42 C 11797201 CLCN6_11797323_G 92.29 G CLCN6_11797323_A 7.71 A 11797323 CLCN6_11797832_G 99.58 G CLCN6_11797832_T 0.42 T 11797832 CLCN6_11798170_C 94.17 C CLCN6_11798170_T 5.83 T 11798170 CLCN6_11798415_G 90.59 G CLCN6_11798415_A 9.41 A 11798415 CLCN6_11798434_T 92.5 T CLCN6_11798434_A 7.5 A 11798434 CLCN6_11798528_T 93.96 T CLCN6_11798528_C 6.04 C 11798528 CLCN6_11798852_T 88.33 T CLCN6_11798852_C 11.67 C 11798852 CLCN6_11799502_C 99.58 C CLCN6_11799502_T 0.42 T 11799502 CLCN6_11799808_A 91.04 A CLCN6_11799808_C 8.96 C 11799808 CLCN6_11800070_A 88.96 A CLCN6_11800070_G 11.04 G 11800070 CLCN6_11801446_T 98.75 T CLCN6_11801446_G 1.25 G 11801446 CYpmidD6_40849445_G 84.22 G CYpmidD6_40849445_A 15.78 A 40849445 NR3C1_142660537_G 75.92 G NR3C1_142660537_T 24.08 T 142660537 ADRB2_148184770_A 66.16 A ADRB2_148184770_T 33.84 T 148184770 ADRB2_148185159_T 74.9 T ADRB2_148185159_A 25.1 A 148185159 ADRB2_148185245_G 56.64 G ADRB2_148185245_A 43.36 A 148185245 ADRB2_148185565_G 57.86 G ADRB2_148185565_A 42.14 A 148185565 ADRB2_148185879_C 99.98 C ADRB2_148185879_A 0.02 A 148185879 ADRB2_148185934_G 66.67 G ADRB2_148185934_A 33.33 A 148185934 ADRB2_148186120_C 66.65 C ADRB2_148186120_G 33.35 G 148186120 ADRB2_148186182_C 95.49 C ADRB2_148186182_T 4.51 T 148186182 ADRB2_148186221_T 66.65 T ADRB2_148186221_C 33.35 C 148186221 SLC22A1_160527926_G 95.51 G SLC22A1_160527926_A 4.49 A 160527926 SLC22A1_160527980_C 88.98 C SLC22A1_160527980_T 11.02 T 160527980 SLC22A1_160531344_C 87.5 C SLC22A1_160531344_T 12.5 T 160531344 SLC22A1_160546396_C 84.21 C SLC22A1_160546396_T 15.79 T 160546396 SLC22A1_160549938_C 72.56 C SLC22A1_160549938_T 27.44 T 160549938 TPMT_18247979_A 99.44 A TPMT_18247979_G 0.56 G 18247979 TPMT_18247998_C 99.44 C TPMT_18247998_T 0.56 T 18247998 TPMT_18248112_C 99.44 C TPMT_18248112_G 0.56 G 18248112 TPMT_18251716_C 98.89 C TPMT_18251716_T 1.11 T 18251716 TPMT_18251748_C 53.33 C TPMT_18251748_T 46.67 T 18251748 TPMT_18255911_C 98.89 C TPMT_18255911_CGTTATTTC 1.11 CGTTATTTC 18255911 TPMT_18255937_G 91.67 G TPMT_18255937_T 8.33 T 18255937 TPMT_18255939_A 98.89 A TPMT_18255939_G 1.11 G 18255939 TPMT_18255998_T 51.67 T TPMT_18255998_C 48.33 C 18255998 TPMT_18256226_T 63.33 T TPMT_18256226_A 36.67 A 18256226 TPMT_18257084_T 90.56 T TPMT_18257084_A 9.44 A 18257084 NOS3_150127045_T 52.13 T NOS3_150127045_A 47.87 A 150127045 NOS3_150127074_A 98.94 A NOS3_150127074_T 1.06 T 150127074 NOS3_150127138_G 97.87 G NOS3_150127138_T 2.13 T 150127138 NOS3_150127384_C 98.94 C NOS3_150127384_T 1.06 T 150127384 NOS3_150127418_C 98.94 C NOS3_150127418_T 1.06 T 150127418 NOS3_150127430_T 97.87 T NOS3_150127430_C 2.13 C 150127430 NOS3_150127538_G 98.94 G NOS3_150127538_A 1.06 A 150127538 NOS3_150127580_C 98.94 C NOS3_150127580_G 1.06 G 150127580 NOS3_150127591_A 65.96 A NOS3_150127591_G 34.04 G 150127591 NOS3_150127618_C 98.94 C NOS3_150127618_T 1.06 T 150127618 NOS3_150127657_C 98.94 C NOS3_150127657_T 1.06 T 150127657 NOS3_150127727_T 66.22 T NOS3_150127727_C 33.78 C 150127727 NOS3_150127824_C 90.43 C NOS3_150127824_T 9.57 T 150127824 NOS3_150127934_A 97.87 A NOS3_150127934_G 2.13 G 150127934 NOS3_150127940_T 97.87 T NOS3_150127940_A 2.13 A 150127940 NOS3_150128821_C 98.94 C NOS3_150128821_T 1.06 T 150128821 NOS3_150129088_A 98.94 A NOS3_150129088_G 1.06 G 150129088 NOS3_150130092_G 89.53 G NOS3_150130092_A 10.47 A 150130092 NOS3_150131482_A 97.87 A NOS3_150131482_G 2.13 G 150131482 NOS3_150131978_A 80.85 A NOS3_150131978_G 19.15 G 150131978 NOS3_150132005_G 98.94 G NOS3_150132005_A 1.06 A 150132005 NOS3_150132254_A 68.09 A NOS3_150132254_G 31.91 G 150132254 NOS3_150132832_T 98.94 T NOS3_150132832_C 1.06 C 150132832 NOS3_150132843_G 87.23 G NOS3_150132843_A 12.77 A 150132843 NOS3_150132862_A 69.15 A NOS3_150132862_G 30.85 G 150132862 NOS3_150134743_G 96.81 G NOS3_150134743_A 3.19 A 150134743 NOS3_150134744_C 97.87 C NOS3_150134744_T 2.13 T 150134744 NOS3_150134870_G 98.94 G NOS3_150134870_T 1.06 T 150134870 NOS3_150134942_A 85.11 A NOS3_150134942_G 14.89 G 150134942 NOS3_150134981_A 70.21 A NOS3_150134981_C 29.79 C 150134981 NOS3_150135380_G 97.87 G NOS3_150135380_A 2.13 A 150135380 NOS3_150135455_G 98.94 G NOS3_150135455_T 1.06 T 150135455 NOS3_150136527_G 53.26 G NOS3_150136527_A 46.74 A 150136527 NOS3_150136808_A 97.83 A NOS3_150136808_C 2.17 C 150136808 NOS3_150136898_G 88.04 G NOS3_150136898_T 11.96 T 150136898 NOS3_150137525_A 78.89 A NOS3_150137525_G 21.11 G 150137525 NOS3_150137582_C 68.89 C NOS3_150137582_T 31.11 T 150137582 NOS3_150137629_C 86.67 C NOS3_150137629_T 13.33 T 150137629 NOS3_150138594_C 91.49 C NOS3_150138594_A 8.51 A 150138594 NOS3_150138927_G 97.87 G NOS3_150138927_A 2.13 A 150138927 NOS3_150138946_G 98.94 G NOS3_150138946_A 1.06 A 150138946 NOS3_150139403_G 96.81 G NOS3_150139403_A 3.19 A 150139403 NOS3_150139431_G 69.15 G NOS3_150139431_A 30.85 A 150139431 NOS3_150139506_G 97.87 G NOS3_150139506_A 2.13 A 150139506 NOS3_150139719_G 69.15 G NOS3_150139719_A 30.85 A 150139719 NOS3_150139839_G 98.94 G NOS3_150139839_A 1.06 A 150139839 NOS3_150139867_C 69.15 C NOS3_150139867_T 30.85 T 150139867 NOS3_150139979_G 98.94 G NOS3_150139979_A 1.06 A 150139979 NOS3_150140080_A 84.04 A NOS3_150140080_T 15.96 T 150140080 NOS3_150140239_A 95.74 A NOS3_150140239_G 4.26 G 150140239 NOS3_150140429_C 70.21 C NOS3_150140429_A 29.79 A 150140429 NOS3_150140689_C 72.34 C NOS3_150140689_T 27.66 T 150140689 NOS3_150140778_C 98.94 C NOS3_150140778_T 1.06 T 150140778 NOS3_150140779_G 98.94 G NOS3_150140779_A 1.06 A 150140779 NOS3_150140875_- 94.68 - NOS3_150140875_A 5.32 A 150140875 NOS3_150140890_A 90.43 A NOS3_150140890_G 9.57 G 150140890 NOS3_150141390_- 88.3 - NOS3_150141390_T 11.7 T 150141390 NOS3_150141470_G 97.87 G NOS3_150141470_T 2.13 T 150141470 NOS3_150141563_G 57.45 G NOS3_150141563_T 42.55 T 150141563 NOS3_150141576_T 97.87 T NOS3_150141576_A 2.13 A 150141576 NOS3_150142048_C 90.43 C NOS3_150142048_A 9.57 A 150142048 NOS3_150142127_A 98.94 A NOS3_150142127_G 1.06 G 150142127 NOS3_150142491_G 57.45 G NOS3_150142491_A 42.55 A 150142491 NOS3_150142848_C 95.74 C NOS3_150142848_- 4.26 - 150142848 NOS3_150143061_G 98.94 G NOS3_150143061_C 1.06 C 150143061 NOS3_150143092_G 98.94 G NOS3_150143092_T 1.06 T 150143092 NOS3_150143258_T 87.23 T NOS3_150143258_C 12.77 C 150143258 NOS3_150143490_G 94.68 G NOS3_150143490_A 5.32 A 150143490 NOS3_150143574_C 98.94 C NOS3_150143574_A 1.06 A 150143574 NOS3_150143633_- 98.94 - NOS3_150143633_G 1.06 G 150143633 NOS3_150144025_C 96.81 C NOS3_150144025_A 3.19 A 150144025 NOS3_150144031_A 67.02 A NOS3_150144031_C 32.98 C 150144031 NOS3_150144341_G 98.94 G NOS3_150144341_A 1.06 A 150144341 NOS3_150144389_C 98.94 C NOS3_150144389_A 1.06 A 150144389 NOS3_150144563_G 50 G NOS3_150144563_A 50 A 150144563 NOS3_150144765_T 86.17 T NOS3_150144765_C 13.83 C 150144765 NOS3_150145136_T 63.83 T NOS3_150145136_C 36.17 C 150145136 NOS3_150145173_G 98.94 G NOS3_150145173_T 1.06 T 150145173 NOS3_150145591_G 91.49 G NOS3_150145591_A 8.51 A 150145591 NOS3_150145737_G 87.23 G NOS3_150145737_A 12.77 A 150145737 NOS3_150145850_G 98.94 G NOS3_150145850_A 1.06 A 150145850 NOS3_150145950_T 76.6 T NOS3_150145950_G 23.4 G 150145950 NOS3_150146107_- 52.13 - NOS3_150146107_T 47.87 T 150146107 NOS3_150146363_A 97.87 A NOS3_150146363_T 2.13 T 150146363 NOS3_150146364_A 97.87 A NOS3_150146364_G 2.13 G 150146364 NOS3_150146498_A 63.83 A NOS3_150146498_G 36.17 G 150146498 NOS3_150146571_G 97.87 G NOS3_150146571_A 2.13 A 150146571 NOS3_150146939_G 97.87 G NOS3_150146939_A 2.13 A 150146939 NOS3_150146943_A 97.87 A NOS3_150146943_C 2.13 C 150146943 NOS3_150147219_G 74.47 G NOS3_150147219_T 25.53 T 150147219 NOS3_150147410_C 97.87 C NOS3_150147410_T 2.13 T 150147410 NOS3_150147552_T 98.94 T NOS3_150147552_C 1.06 C 150147552 NOS3_150148332_G 98.94 G NOS3_150148332_A 1.06 A 150148332 NOS3_150148333_C 98.94 C NOS3_150148333_A 1.06 A 150148333 NOS3_150149879_C 98.94 C NOS3_150149879_G 1.06 G 150149879 NOS3_150149966_G 96.81 G NOS3_150149966_C 3.19 C 150149966 NOS3_150150125_C 97.87 C NOS3_150150125_T 2.13 T 150150125 NOS3_150150275_A 98.94 A NOS3_150150275_G 1.06 G 150150275 NOS3_150150312_G 98.94 G NOS3_150150312_A 1.06 A 150150312 NOS3_150150382_C 97.87 C NOS3_150150382_G 2.13 G 150150382 NOS3_150150614_T 97.87 T NOS3_150150614_C 2.13 C 150150614 NOS3_150150629_G 97.87 G NOS3_150150629_A 2.13 A 150150629 NOS3_150150879_C 97.87 C NOS3_150150879_T 2.13 T 150150879 NOS3_150150918_G 97.87 G NOS3_150150918_C 2.13 C 150150918 NOS3_150151104_C 96.81 C NOS3_150151104_G 3.19 G 150151104 NOS3_150151258_A 98.94 A NOS3_150151258_G 1.06 G 150151258 NOS3_150151308_G 98.94 G NOS3_150151308_A 1.06 A 150151308 NOS3_150151419_C 98.94 C NOS3_150151419_G 1.06 G 150151419 NOS3_150151436_G 98.94 G NOS3_150151436_A 1.06 A 150151436 ABCB1_86794712_G 99.8 G ABCB1_86794712_A 0.2 A 86794712 ABCB1_86810385_C 98.58 C ABCB1_86810385_T 1.42 T 86810385 ABCB1_86810401_G 88.1 G ABCB1_86810401_A 11.9 A 86810401 ABCB1_86815458_A 99.19 A ABCB1_86815458_G 0.81 G 86815458 ABCB1_86819792_G 99.6 G ABCB1_86819792_A 0.4 A 86819792 ABCB1_86823277_G 52.24 G ABCB1_86823277_A 47.76 A 86823277 ABCB1_86823794_T 52.22 T ABCB1_86823794_C 47.78 C 86823794 ABCB1_86824094_C 93.35 C ABCB1_86824094_T 6.65 T 86824094 ABCB1_86824267_G 99.78 G ABCB1_86824267_A 0.22 A 86824267 ABCB1_86824586_T 99.8 T ABCB1_86824586_G 0.2 G 86824586 ABCB1_86824849_A 53.3 A ABCB1_86824849_G 46.7 G 86824849 ABCB1_86844215_G 82.39 G ABCB1_86844215_T 17.61 T 86844215 ABCB1_86874582_C 98.73 C ABCB1_86874582_A 1.27 A 86874582 ABCB1_86875086_A 99.8 A ABCB1_86875086_G 0.2 G 86875086 ABCB1_86875105_A 99.59 A ABCB1_86875105_T 0.41 T 86875105 ABCB1_86875191_T 99.8 T ABCB1_86875191_C 0.2 C 86875191 CYP3A_98890565_T 73.71 T CYP3A_98890565_C 26.29 C 98890565 CYP3A_98890625_T 83.89 T CYP3A_98890625_A 15.48 A CYP3A_98890625_A 0.63 C 98890625 CYP3A_98890677_T 99.48 T CYP3A_98890677_C 0.52 C 98890677 CYP3A_98891139_G 97.94 G CYP3A_98891139_A 2.06 A 98891139 CYP3A_98891358_T 98.45 T CYP3A_98891358_A 1.55 A 98891358 CYP3A_98891643_T 95.88 T CYP3A_98891643_C 4.12 C 98891643 CYP3A_98891780_G 98.45 G CYP3A_98891780_A 1.55 A 98891780 CYP3A_98892154_A 97.94 A CYP3A_98892154_- 2.06 - 98892154 CYP3A_98892293_T 99.48 T CYP3A_98892293_C 0.52 C 98892293 CYP3A_98894650_C 80.08 C CYP3A_98894650_G 13.35 G CYP3A_98894650_G 5.08 T 98894650 CYP3A_98894887_C 84.03 C CYP3A_98894887_G 15.55 G CYP3A_98894887_G 0.42 A 98894887 CYP3A_98894969_A 99.48 A CYP3A_98894969_G 0.52 G 98894969 CYP3A_98895126_A 82.5 A CYP3A_98895126_T 13.96 T CYP3A_98895126_T 2.5 G 98895126 CYP3A_98895227_G 99.48 G CYP3A_98895227_A 0.52 A 98895227 CYP3A_98895760_(ATTT)10 64.95 (ATTT)10 CYP3A_98895760_(ATTT)11 32.99 (ATTT)11 CYP3A_98895760_(ATTT)11 2.06 (ATTT)12 98895760 CYP3A_98903011_G 99.48 G CYP3A_98903011_A 0.52 A 98903011 CYP3A_98903175_C 97.42 C CYP3A_98903175_T 2.58 T 98903175 CYP3A_98903294_C 97.94 C CYP3A_98903294_T 2.06 T 98903294 CYP3A_98905150_C 99.48 C CYP3A_98905150_T 0.52 T 98905150 CYP3A_98905385_G 98.45 G CYP3A_98905385_A 1.55 A 98905385 CYP3A_98905570_G 97.42 G CYP3A_98905570_C 2.58 C 98905570 CYP3A_98905971_C 99.48 C CYP3A_98905971_T 0.52 T 98905971 CYP3A_98906613_C 99.48 C CYP3A_98906613_T 0.52 T 98906613 CYP3A_98907456_A 98.97 A CYP3A_98907456_G 1.03 G 98907456 CYP3A_98907486_G 83.73 G CYP3A_98907486_C 13.92 C CYP3A_98907486_C 1.76 A 98907486 CYP3A_98909485_C 99.48 C CYP3A_98909485_T 0.52 T 98909485 CYP3A_98909505_G 99.48 G CYP3A_98909505_A 0.52 A 98909505 CYP3A_98909510_G 99.48 G CYP3A_98909510_C 0.52 C 98909510 CYP3A_98909563_C 99.48 C CYP3A_98909563_G 0.52 G 98909563 CYP3A_98909631_G 99.48 G CYP3A_98909631_A 0.52 A 98909631 CYP3A_98914816_T 99.48 T CYP3A_98914816_C 0.52 C 98914816 CYP3A_98914969_C 98.97 C CYP3A_98914969_T 1.03 T 98914969 CYP3A_98915070_C 99.48 C CYP3A_98915070_- 0.52 - 98915070 CYP3A_98915190_G 73.66 G CYP3A_98915190_A 24.5 A CYP3A_98915190_A 1.22 C 98915190 CYP3A_98915275_T 99.48 T CYP3A_98915275_G 0.52 G 98915275 CYP3A_98916961_C 81.43 C CYP3A_98916961_G 14.14 G CYP3A_98916961_G 3.38 T 98916961 CYP3A_98917388_T 99.48 T CYP3A_98917388_- 0.52 - 98917388 CYP3A_98921846_A 99.48 A CYP3A_98921846_G 0.52 G 98921846 CYP3A_98921852_G 95.36 G CYP3A_98921852_A 4.64 A 98921852 CYP3A_98922185_A 99.48 A CYP3A_98922185_C 0.52 C 98922185 CYP3A_98922244_C 83.33 C CYP3A_98922244_G 14.98 G CYP3A_98922244_G 1.05 T 98922244 CYP3A_98922256_G 83.82 G CYP3A_98922256_C 15.34 C CYP3A_98922256_C 0.63 A 98922256 CYP3A_98922721_C 98.45 C CYP3A_98922721_A 1.55 A 98922721 CYP3A_98922879_T 99.48 T CYP3A_98922879_C 0.52 C 98922879 CYP3A5pmid_98999459_A 98.97 A CYP3A5pmid_98999459_T 1.03 T 98999459 CYP3A5pmid_98999724_C 97.42 C CYP3A5pmid_98999724_T 2.58 T 98999724 CYP3A5pmid_98999836_T 98.45 T CYP3A5pmid_98999836_G 1.55 G 98999836 CYP3A5pmid_98999929_C 99.46 C CYP3A5pmid_98999929_T 0.54 T 98999929 CYP3A5pmid_99000078_C 99.46 C CYP3A5pmid_99000078_T 0.54 T 99000078 CYP3A5pmid_99000263_T 99.46 T CYP3A5pmid_99000263_C 0.54 C 99000263 CYP3A5pmid_99000839_A 99.48 A CYP3A5pmid_99000839_C 0.52 C 99000839 CYP3A5pmid_99000975_T 90.21 T CYP3A5pmid_99000975_G 9.79 G 99000975 CYP3A5pmid_99001088_T 98.97 T CYP3A5pmid_99001088_G 1.03 G 99001088 CYP3A5pmid_99001251_G 97.94 G CYP3A5pmid_99001251_T 2.06 T 99001251 CYP3A5pmid_99003175_T 90.4 T CYP3A5pmid_99003175_A 9.22 A CYP3A5pmid_99003175_A 0.25 C 99003175 CYP3A5pmid_99003266_C 95.56 C CYP3A5pmid_99003266_T 4.44 T 99003266 CYP3A5pmid_99003802_G 82.47 G CYP3A5pmid_99003802_A 17.53 A 99003802 CYP3A5pmid_99003894_T 98.45 T CYP3A5pmid_99003894_C 1.55 C 99003894 CYP3A5pmid_99004451_C 99.86 C CYP3A5pmid_99004451_T 0.14 T 99004451 CYP3A5pmid_99004562_A 99.64 A CYP3A5pmid_99004562_C 0.36 C 99004562 CYP3A_99006038_G 98.92 G CYP3A_99006038_C 1.08 C 99006038 CYP3A_99006117_G 62.5 G CYP3A_99006117_A 26.25 A CYP3A_99006117_A 7.03 C 99006117 CYP3A_99008911_T 97.94 T CYP3A_99008911_G 2.06 G 99008911 CYP3A_99009053_T 98.45 T CYP3A_99009053_C 1.55 C 99009053 CYP3A_99009161_C 99.48 C CYP3A_99009161_T 0.52 T 99009161 CYP3A_99009323_C 99.46 C CYP3A_99009323_T 0.54 T 99009323 CYP3A_99009734_C 72.16 C CYP3A_99009734_T 27.84 T 99009734 CYP3A_99010102_C 91.24 C CYP3A_99010102_T 8.76 T 99010102 CYP3A_99010205_C 98.45 C CYP3A_99010205_T 1.55 T 99010205 CYP3A_99010293_A 99.48 A CYP3A_99010293_T 0.52 T 99010293 CYP3A_99010370_T 66.27 T CYP3A_99010370_C 33.73 C 99010370 CYP3A_99010510_T 97.99 T CYP3A_99010510_A 2.01 A 99010510 CYP3A_99010564_T 99.73 T CYP3A_99010564_C 0.27 C 99010564 CYP3A_99010594_T 84.62 T CYP3A_99010594_G 15.38 G 99010594 100 C 99010633 CYP3A_99010719_C 90.48 C CYP3A_99010719_G 8.55 G CYP3A_99010719_G 0.6 T 99010719 CYP3A_99010744_C 99.59 C CYP3A_99010744_G 0.41 G 99010744 CYP3A_99011990_T 98.13 T CYP3A_99011990_G 1.87 G 99011990 CYP3A_99012043_G 98.89 G CYP3A_99012043_C 1.11 C 99012043 CYP3A_99012078_G 90.49 G CYP3A_99012078_C 8.66 C CYP3A_99012078_C 0.73 A 99012078 CYP3A_99012518_G 99.45 G CYP3A_99012518_C 0.55 C 99012518 CYP3A_99012590_G 99.73 G CYP3A_99012590_A 0.27 A 99012590 CYP3A_99012707_G 99.48 G CYP3A_99012707_A 0.52 A 99012707 CYP3A_99020198_T 99.45 T CYP3A_99020198_A 0.55 A 99020198 CYP3A_99020441_T 99.26 T CYP3A_99020441_C 0.74 C 99020441 CYP3A_99021557_G 93.81 G CYP3A_99021557_T 6.19 T 99021557 CYP3A_99026312_T 99.73 T CYP3A_99026312_C 0.27 C 99026312 CYP3A_99026389_A 99.72 A CYP3A_99026389_T 0.28 T 99026389 CYP3A_99026417_C 99.73 C CYP3A_99026417_A 0.27 A 99026417 CYP3A_99026475_A 99.47 A CYP3A_99026475_G 0.53 G 99026475 CYP3A_99026574_A 99.73 A CYP3A_99026574_C 0.27 C 99026574 CYP3A_99026747_A 72.61 A CYP3A_99026747_G 27.39 G 99026747 GGH_64114005_T 61.11 T GGH_64114005_G 38.89 G 64114005 GGH_64114235_G 77.78 G GGH_64114235_T 22.22 T 64114235 GGH_64114282_C 66.67 C GGH_64114282_T 33.33 T 64114282 GGH_64114305_C 94.44 C GGH_64114305_A 5.56 A 64114305 GGH_64114486_C 61.11 C GGH_64114486_G 38.89 G 64114486 GGH_64114530_A 77.78 A GGH_64114530_G 22.22 G 64114530 GGH_64114560_C 94.44 C GGH_64114560_T 5.56 T 64114560 GGH_64115068_G 66.67 G GGH_64115068_A 33.33 A 64115068 GGH_64115399_T 61.11 T GGH_64115399_G 38.89 G 64115399 GGH_64115402_A 83.33 A GGH_64115402_G 16.67 G 64115402 ABCC2_101534437_T 99.4 T ABCC2_101534437_A 0.6 A 101534437 ABCC2_101550159_G 99.25 G ABCC2_101550159_A 0.75 A 101550159 ABCC2_101553805_G 86.61 G ABCC2_101553805_A 13.39 A 101553805 ABCC2_101554013_C 99.7 C ABCC2_101554013_T 0.3 T 101554013 ABCC2_101555147_A 99.85 A ABCC2_101555147_G 0.15 G 101555147 ABCC2_101557847_T 99.8 T ABCC2_101557847_G 0.2 G 101557847 ABCC2_101562806_T 99.55 T ABCC2_101562806_C 0.45 C 101562806 ABCC2_101568942_T 99.39 T ABCC2_101568942_G 0.61 G 101568942 ABCC2_101581375_C 99.85 C ABCC2_101581375_A 0.15 A 101581375 ABCC2_101581418_A 99.85 A ABCC2_101581418_G 0.15 G 101581418 ABCC2_101581727_T 99.7 T ABCC2_101581727_C 0.3 C 101581727 ABCC2_101581808_A 99.85 A ABCC2_101581808_G 0.15 G 101581808 ABCC2_101585965_G 97.49 G ABCC2_101585965_T 2.51 T 101585965 ABCC2_101585986_T 95.56 T ABCC2_101585986_A 4.44 A 101585986 ABCC2_101593621_A 99.7 A ABCC2_101593621_G 0.3 G 101593621 ABCC2_101594097_C 99.25 C ABCC2_101594097_T 0.75 T 101594097 ABCC2_101601284_G 91.44 G ABCC2_101601284_A 8.56 A 101601284 GSTpgkb_67109265_A 62.62 A GSTpgkb_67109265_G 37.38 G 67109265 MTHFR_11785193_G 93.54 G MTHFR_11785193_A 6.46 A 11785193 MTHFR_11788742_A 74.58 A MTHFR_11788742_C 25.42 C 11788742 SLC19A1_45782222_G 55.69 G SLC19A1_45782222_A 44.31 A 45782222 CYpmidD6_40849584_T 99.9 T CYpmidD6_40849584_- 0.1 - 40849584 CYpmidD6_40850270_C 96.61 C CYpmidD6_40850270_T 3.39 T 40850270 CYpmidD6_40851192_C 69.84 C CYpmidD6_40851192_T 30.16 T 40851192 NR3C1_142759510_A 98.42 A NR3C1_142759510_G 1.58 G 142759510 NR3C1_142760405_T 99.16 T NR3C1_142760405_G 0.84 G 142760405 ADRB2_148186633_G 56.81 G ADRB2_148186633_A 43.19 A 148186633 ADRB2_148186666_C 67.8 C ADRB2_148186666_G 32.2 G 148186666 ADRB2_148187078_C 99.04 C ADRB2_148187078_T 0.96 T 148187078 ADRB2_148187246_C 98.84 C ADRB2_148187246_G 1.16 G 148187246 SLC22A1_160513559_C 97.77 C SLC22A1_160513559_T 2.23 T 160513559 SLC22A1_160521615_C 92.24 C SLC22A1_160521615_G 7.76 G 160521615 SLC22A1_160528054_C 92.86 C SLC22A1_160528054_T 7.14 T 160528054 SLC22A1_160531256_G 68.21 G SLC22A1_160531256_A 31.79 A 160531256 TPMT_18238897_A 94.51 A TPMT_18238897_G 5.49 G 18238897 TPMT_18247207_G 97.4 G TPMT_18247207_A 2.6 A 18247207 NOS3_150131204_G 95.74 G NOS3_150131204_A 4.26 A 150131204 NOS3_150133759_G 68.48 G NOS3_150133759_T 31.52 T 150133759 NOS3_150144288_G 98.94 G NOS3_150144288_A 1.06 A 150144288 NOS3_150144992_G 97.87 G NOS3_150144992_T 2.13 T 150144992 NOS3_150145683_A 98.94 A NOS3_150145683_T 1.06 T 150145683 ABCB1_86778302_G 99.79 G ABCB1_86778302_A 0.21 A 86778302 ABCB1_86783310_T 96.59 T ABCB1_86783310_A 3.41 A 86783310 ABCB1_86789329_C 99.8 C ABCB1_86789329_G 0.2 G 86789329 ABCB1_86805269_G 59.35 G ABCB1_86805269_T 38.76 T ABCB1_86805269_T 1.89 A 86805269 ABCB1_86824460_G 98.82 G ABCB1_86824460_A 1.18 A 86824460 ABCB1_86874091_A 95.06 A ABCB1_86874091_G 4.94 G 86874091 GGH_64101318_C 91.4 C GGH_64101318_T 8.6 T 64101318 GGH_64113791_G 72.22 G GGH_64113791_A 27.78 A 64113791 GGH_64113866_T 61.11 T GGH_64113866_C 38.89 C 64113866 ABCC2_101534480_A 99.4 A ABCC2_101534480_G 0.6 G 101534480 ABCC2_101553775_C 98.8 C ABCC2_101553775_T 1.2 T 101553775 ABCC2_101553990_G 99.8 G ABCC2_101553990_T 0.2 T 101553990 ABCC2_101562870_C 99.85 C ABCC2_101562870_A 0.15 A 101562870 ABCC2_101581408_G 97.77 G ABCC2_101581408_A 2.23 A 101581408 ABCC2_101584264_T 99.7 T ABCC2_101584264_C 0.3 C 101584264 ABCC2_101585984_G 99.8 G ABCC2_101585984_A 0.2 A 101585984 ABCC2_101594197_C 66.72 C ABCC2_101594197_T 33.28 T 101594197 ABCC2_101595445_C 98.79 C ABCC2_101595445_T 1.21 T 101595445 ABCC2_101595493_C 96.99 C ABCC2_101595493_T 3.01 T 101595493 ABCC2_101596803_C 99.85 C ABCC2_101596803_T 0.15 T 101596803 ABCC2_101596851_G 95.33 G ABCC2_101596851_T 4.67 T 101596851 ABCC2_101600445_G 94.88 G ABCC2_101600445_A 5.12 A 101600445 ABCC2_101600523_C 96.85 C ABCC2_101600523_T 3.15 T 101600523 ABCC2_101601267_C 99.4 C ABCC2_101601267_T 0.6 T 101601267 MTHFR_11788723_T 91.25 T MTHFR_11788723_C 8.75 C 11788723 MTHFR_11789162_C 90.17 C MTHFR_11789162_T 9.83 T 11789162 NR3C1_142641683_T 85.31 T NR3C1_142641683_C 14.69 C 142641683 NR3C1_142642473_C 92.42 C NR3C1_142642473_T 7.58 T 142642473 100 C 142759794 ADRB2_148186839_G 75.45 G ADRB2_148186839_A 24.55 A 148186839 ADRB2_148187110_C 74.84 C ADRB2_148187110_A 25.16 A 148187110 ADRB2_148187640_G 68.71 G ADRB2_148187640_C 31.29 C 148187640 ADRB2_148187757_T 99.9 T ADRB2_148187757_C 0.1 C 148187757 ADRB2_148187826_G 58.05 G ADRB2_148187826_A 41.95 A 148187826 SLC22A1_160513534_T 73.76 T SLC22A1_160513534_C 26.24 C 160513534 SLC22A1_160550007_A 98.96 A SLC22A1_160550007_C 1.04 C 160550007 TPMT_18247193_T 75.28 T TPMT_18247193_C 24.72 C 18247193 TPMT_18247244_A 99.81 A TPMT_18247244_C 0.19 C 18247244 TPMT_18251833_C 99.25 C TPMT_18251833_T 0.75 T 18251833 TPMT_18257268_C 99.81 C TPMT_18257268_T 0.19 T 18257268 NOS3_150133374_C 70.21 C NOS3_150133374_T 29.79 T 150133374 NOS3_150145485_C 98.94 C NOS3_150145485_T 1.06 T 150145485 NOS3_150148040_G 98.94 G NOS3_150148040_A 1.06 A 150148040 NOS3_150148555_T 92.55 T NOS3_150148555_C 7.45 C 150148555 ABCB1_86783296_C 52.84 C ABCB1_86783296_T 47.16 T 86783296 ABCB1_86805296_C 99.7 C ABCB1_86805296_T 0.3 T 86805296 ABCB1_86824252_C 59.55 C ABCB1_86824252_T 40.45 T 86824252 ABCB1_86835328_A 99.85 A ABCB1_86835328_G 0.15 G 86835328 GGH_64110819_G 94.44 G GGH_64110819_A 5.56 A 64110819