]> http://dumontierlab.com en Natalia Villanueva-Rosales September 1, 2007 yOWL JBI data 2.0 SGD biological data subset mapped to the yOWL ontology Michel Dumontier S000001057 Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export 134547 136526 2005-11-07 1996-07-31 S000001094 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles 210842 211972 2005-11-07 1996-07-31 S000001399 Protein that associates with ribosomes; putative metalloprotease 92788 89948 1994-12-10 1994-12-10 S000001500 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities 406884 404833 2005-12-15 1996-07-31 S000001582 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 256116 255364 2005-12-15 1996-07-31 2005-12-15 S000001625 Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2 178520 179179 2004-02-13 1996-07-31 S000001773 Presequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase 565534 564941 2005-12-15 1996-07-31 S000001881 Subunit of the INO80 chromatin remodeling complex 109924 107846 1996-07-31 1996-07-31 S000002234 Protein of unknown function, may be involved in chromatin silencing 321552 320668 2004-02-11 1996-07-31 S000002268 Protein of unknown function that associates with ribosomes 264964 264512 2004-02-11 1996-07-31 S000002524 Protein of unknown function that associates with ribosomes; has a putative RNA binding domain 685640 683943 2006-04-13 1996-07-31 S000002538 F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 718457 716787 2006-04-13 1996-07-31 S000002570 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p 781420 781947 2006-04-13 1996-07-31 S000002586 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling 819193 818705 2006-04-13 1996-07-31 S000002627 Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding 906848 905451 2006-04-13 1996-07-31 S000002747 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p 1150514 1149945 2006-04-13 1996-07-31 S000002806 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 1267463 1269394 2006-04-13 1996-07-31 S000002890 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p 1420830 1420423 2006-04-13 1996-07-31 S000002923 RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts 1473421 1474764 2006-04-13 1996-07-31 S000002954 Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates 42624 42400 1996-07-31 1996-07-31 S000002972 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm 491960 490707 2004-07-20 1996-07-31 S000002973 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments 490551 489712 2004-07-20 1996-07-31 S000003265 Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes 554971 554252 2004-07-20 1996-07-31 S000003510 Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data 1046737 1048470 2005-11-29 1996-07-31 S000003568 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p 387433 386363 2006-10-04 2004-01-27 1996-07-31 S000003568 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p 387433 386363 2006-10-04 2004-01-27 1996-07-31 S000003608 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery 305857 305216 2006-10-04 1996-07-31 S000003775 Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; has homology to human protein DRP1, which interacts with human Tma20p homolog MCT-1 461822 462418 2006-10-04 1996-07-31 S000003844 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling 583726 584997 2006-10-04 1996-07-31 S000003945 Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing 100200 99043 1996-07-31 1996-07-31 S000004087 Putative nuclear ubiquitin ligase, based on computational analysis of large-scale protein-protein interaction data; has similarity to F-box proteins; identified in association with Cdc53p, Skp1p and Ubi4 in large-scale studies 337266 336232 1996-07-31 1996-07-31 S000004211 Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus 579026 578364 2004-02-05 1996-07-31 S000004214 F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene 586466 587575 2004-02-05 1996-07-31 S000004315 Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p 778952 778173 2004-02-05 1996-07-31 S000004317 Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein 781379 781143 2004-02-05 1996-07-31 S000004377 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin 893390 892992 2004-02-05 1996-07-31 S000004536 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments 131572 129749 1996-07-31 1996-07-31 S000004627 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling 323299 324186 1996-07-31 1996-07-31 S000004647 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif 355383 356810 1996-07-31 1996-07-31 S000004986 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments 551988 549469 2005-11-07 1997-01-28 S000005106 Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein 331324 332156 2005-11-07 1999-11-17 1996-07-31 S000005106 Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein 331324 332156 2005-11-07 1999-11-17 1996-07-31 S000005174 Elongin A, F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation 218663 217524 2005-11-07 1996-07-31 S000005189 Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p 186886 186347 2005-11-07 1996-07-31 S000005197 Protein involved in mRNA export, component of the transcription export (TREX) complex 170019 171287 2005-11-07 1996-07-31 S000005255 Putative F-box protein; analysis of integrated high-throughput datasets predicts an involvement in ubiquitin-dependent protein catabolism 51687 49396 1996-07-31 1996-07-31 S000005272 Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain 23274 22834 1996-07-31 1996-07-31 S000005305 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation 670195 669776 2005-11-07 1997-01-28 S000005471 Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain 108896 108258 2006-01-05 1996-07-31 S000005477 Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response 97551 99488 2006-01-05 1996-07-31 S000005506 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery 48863 49447 2006-01-05 2003-09-22 1996-07-31 S000005530 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function 333593 334357 2006-01-05 1996-07-31 S000005705 Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs 672412 671846 2006-01-05 1996-07-31 S000005778 Protein of unknown function that associates with ribosomes 803668 804204 2006-01-05 1996-07-31 2006-01-05 S000005985 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p 429613 428708 2004-07-21 1996-07-31 S000006309 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments 739567 736982 2004-07-21 1996-07-31 S000028421 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis 185017 184808 2004-02-13 2002-06-20 S000029174 Negative regulator gene in general amino acid biosynthetic pathway, possibly upstream of GCN4 S000029463 H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U2258 and U2260; encoded within the intron of NOG2/YNR053C 722212 721939 2005-11-07 2003-12-09 Abraham PR, et al. 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(2005) Pam17 Is Required for Architecture and Translocation Activity of the Mitochondrial Protein Import Motor Mol Cell Biol 25(17):7449-7458 histone deacetylase complex ribonucleoprotein complex histone acetyltransferase complex mitochondrial inner membrane peptidase complex DASH complex ubiquitin ligase complex pore complex nuclear pore alpha DNA polymerase:primase complex transcription factor complex spliceosome small nucleolar ribonucleoprotein complex mitochondrial inner membrane presequence translocase complex ribosome mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex Rab-protein geranylgeranyltransferase complex transcription export complex proteasome complex (sensu the Eukaryota research community) transcription elongation factor complex signalosome complex GINS complex chromatin remodeling complex ISW1 complex Golgi transport complex YDR163W - Exhibits sensitivity at 5 generations when grown in synthetic complete - thr medium.. Results from large scale deletion study. Phenotype determined by fitness score. Systematic deletion Exhibits sensitivity at 5 generations when grown in synthetic complete - thr medium. YDR163W - viable. Results from large scale deletion study. Systematic deletion viable YDL076C - viable. Results from large scale deletion study. Systematic deletion viable YDL110C - viable. Results from large scale deletion study. Systematic deletion viable YDR117C - Exhibits sensitivity at 5 generations when grown in synthetic complete medium.. Results from large scale deletion study. Phenotype determined by fitness score. Systematic deletion Exhibits sensitivity at 5 generations when grown in synthetic complete medium. YDR117C - viable. Results from large scale deletion study. Systematic deletion viable YDR131C - viable. Results from large scale deletion study. Systematic deletion viable YDR179C - viable. Results from large scale deletion study. Systematic deletion viable YDR219C - abnormal mitochondrial morphology. Null abnormal mitochondrial morphology YDR219C - viable. Results from large scale deletion study. Systematic deletion viable YDR339C - inviable. Null inviable YDR339C - inviable. Results from large scale deletion study. Systematic deletion inviable YDR398W - inviable. Results from large scale deletion study. Systematic deletion inviable YDR482C - viable. Results from large scale deletion study. Systematic deletion viable YDR515W - Copper resistance. Overexpression Copper resistance YDR515W - viable. Null viable YDR515W - copper sensitive. Null copper sensitive YEL059C-A - Null mutant is viable; proteolytic processing is prevented or reduced. Free text Null mutant is viable; proteolytic processing is prevented or reduced YFL013C - viable. Null viable YFL013C - Exhibits sensitivity at 20 generations when grown in 1 M NaCl.. Results from large scale deletion study. Phenotype determined by fitness score. Systematic deletion Exhibits sensitivity at 20 generations when grown in 1 M NaCl. YGL004C - viable. Results from large scale deletion study. Systematic deletion viable YGL005C - viable. Results from large scale deletion study. Systematic deletion viable YGR033C - viable. Results from large scale deletion study. Systematic deletion viable YJR084W - viable. Results from large scale deletion study. Systematic deletion viable YLL022C - Null mutant is viable and does not show any obvious phenotypes. Free text Null mutant is viable and does not show any obvious phenotypes YGR278W - inviable. Results from large scale deletion study. Systematic deletion inviable YHR015W - viable. Results from large scale deletion study. Systematic deletion viable YHR052W - Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins.. Free text Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins. YIL137C - viable. Results from large scale deletion study. Systematic deletion viable YJL031C - inviable. Results from large scale deletion study. Systematic deletion inviable YJL072C - inviable. Results from large scale deletion study. Systematic deletion inviable YKL017C - viable. Results from large scale deletion study. Systematic deletion viable YKL099C - inviable. Results from large scale deletion study. Systematic deletion inviable YKL138C-A - inviable. Null inviable YKL142W - viable. Results from large scale deletion study. Systematic deletion viable YKR065C - viable. Results from large scale deletion study. Systematic deletion viable YLR097C - viable. Results from large scale deletion study. Systematic deletion viable YLR221C - viable. Results from large scale deletion study. Systematic deletion viable YLR323C - inviable. Results from large scale deletion study. Systematic deletion inviable YLR325C - viable. Results from large scale deletion study. Systematic deletion viable YLR385C - viable. Results from large scale deletion study. Systematic deletion viable YML071C - viable. Results from large scale deletion study. Systematic deletion viable YMR025W - viable. Results from large scale deletion study. Systematic deletion viable YMR044W - viable. Results from large scale deletion study. Systematic deletion viable YOL146W - inviable. Results from large scale deletion study. Systematic deletion inviable YNL041C - viable. Results from large scale deletion study. Systematic deletion viable YNL162W - inviable. Results from large scale deletion study. Systematic deletion inviable YNL230C - viable. Results from large scale deletion study. Systematic deletion viable YNL245C - inviable. Results from large scale deletion study. Systematic deletion inviable YNL253W - viable. Results from large scale deletion study. Systematic deletion viable YNL311C - viable. Results from large scale deletion study. Systematic deletion viable YNL328C - Null mutant is viable, mdj1 mdj2 double mutants display severe grwoth defects at high temperature. Free text Null mutant is viable, mdj1 mdj2 double mutants display severe grwoth defects at high temperature YNL328C - viable. Results from large scale deletion study. Systematic deletion viable YNR022C - viable. Results from large scale deletion study. Systematic deletion viable snR191 - viable. Null viable YOL111C - viable. Results from large scale deletion study. Systematic deletion viable YOL117W - Null: viable. Other phenotypes: Cdc53 accumulates exclusively in the 'rubinylated' form in an rri2-null. Free text Null: viable. Other phenotypes: Cdc53 accumulates exclusively in the 'rubinylated' form in an rri2-null YOL117W - viable. Results from large scale deletion study. Systematic deletion viable YOR004W - inviable. Results from large scale deletion study. Systematic deletion inviable YOR179C - viable. Results from large scale deletion study. Systematic deletion viable YOR252W - viable. Results from large scale deletion study. Systematic deletion viable YPL064C - viable. Results from large scale deletion study. Systematic deletion viable YPR105C - inviable. Results from large scale deletion study. Systematic deletion inviable GCD3 - Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis. Free text Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis YLR224W - viable. Results from large scale deletion study. Systematic deletion viable YJR014W - viable. Results from large scale deletion study. Systematic deletion viable protein modifications